Patents by Inventor Daniel H. Kim
Daniel H. Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8712546Abstract: Some embodiments of the present invention provide neurostimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide neurostimulation systems adapted for selective neurostimulation of one or more nerve root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.Type: GrantFiled: March 19, 2008Date of Patent: April 29, 2014Assignees: Spinal Modulation, Inc., The Board of Trustees of the Leland Stanford Junior UniversityInventors: Daniel H. Kim, Mir A. Imran
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Publication number: 20140081332Abstract: A percutaneous and minimally invasive instrument for inserting an interspinous process spacer into a patient is disclosed. The insertion instrument includes a first assembly connected to a handle assembly. The first assembly includes an inner shaft located inside an outer shaft and configured for relative translational motion with respect to the outer shaft. The relative translational motion causes one of the outer or inner shafts to move with respect to the other and thereby deflect at least one prong formed on one of the inner or outer shafts wherein such deflection causes engagement with a juxtapositioned interspinous spacer. The instrument further includes a driving tool configured for removable insertion into a proximal end of a passageway of the instrument. The driving tool has a distal spacer engaging portion configured to engage that part of the spacer requiring activation for deployment of the spacer from at least one undeployed configuration to at least one deployed configuration and vice versa.Type: ApplicationFiled: November 25, 2013Publication date: March 20, 2014Applicant: VERTIFLEX, INC.Inventors: Moti Altarac, Shawn Tebbe, Daniel H. Kim
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Patent number: 8613747Abstract: A percutaneous and minimally invasive instrument for inserting an interspinous process spacer into a patient is disclosed. The insertion instrument includes a first assembly connected to a handle assembly. The first assembly includes an inner shaft located inside an outer shaft; the inner and outer shafts being configured for relative translational motion with respect to each other to thereby deflect at least one prong formed on one of the inner or outer shafts wherein such deflection causes engagement with a juxtapositioned interspinous spacer. The instrument further includes a driving tool configured for removable insertion into a proximal end of a passageway of the instrument. The driving tool has a distal spacer engaging portion configured to engage that part of the spacer requiring activation for deployment of the spacer from at least one undeployed configuration to at least one deployed configuration and vice versa.Type: GrantFiled: December 18, 2008Date of Patent: December 24, 2013Assignee: VertiFlex, Inc.Inventors: Moti Altarac, Shawn Tebbe, Daniel H. Kim
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Publication number: 20130289622Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and a mechanical actuation means for expanding the expandable member. The methods involve the implantation of one or more devices or expandable spacers.Type: ApplicationFiled: October 23, 2012Publication date: October 31, 2013Inventor: Daniel H. Kim
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Patent number: 8513401Abstract: The present invention relates to transcriptional gene silencing (TGS) in mammalian, including human, cells that is mediated by small interfering RNA (siRNA) molecules. The present invention also relates to a double stranded nucleic acid that directs methylation of histones associated with target genes that produce low copy promoter-specific RNA. It has been found that siRNAs can be used to direct methylation of histones in mammalian, including human, cells.Type: GrantFiled: May 3, 2010Date of Patent: August 20, 2013Assignee: City of HopeInventors: John J. Rossi, Daniela Castanotto, Gerd Pfeifer, Stella Tommasi, Kevin V. Morris, Daniel H. Kim
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Publication number: 20130172933Abstract: An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal caming surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the caming surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.Type: ApplicationFiled: September 14, 2012Publication date: July 4, 2013Applicant: VertiFlex, Inc.Inventors: Moti Altarac, Shawn Tebbe, Joey Camia Reglos, Yang Cheng, Murali P. Kadaba, Daniel H. Kim
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Publication number: 20130172932Abstract: An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal earning surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the earning surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.Type: ApplicationFiled: September 14, 2012Publication date: July 4, 2013Applicant: VertiFlex, Inc.Inventors: Moti Altarac, Shawn Tebbe, Joey Camia Reglos, Yang Cheng, Murali P. Kadaba, Daniel H. Kim
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Publication number: 20130165991Abstract: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.Type: ApplicationFiled: December 5, 2012Publication date: June 27, 2013Inventors: Daniel H. KIM, Mir A. IMRAN, Jeffery M. KRAMER
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Patent number: 8425559Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.Type: GrantFiled: November 7, 2006Date of Patent: April 23, 2013Assignee: VertiFlex, Inc.Inventors: Shawn Tebbe, Moti Altarac, Daniel H. Kim
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Patent number: 8409282Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.Type: GrantFiled: July 26, 2005Date of Patent: April 2, 2013Assignee: VertiFlex, Inc.Inventor: Daniel H. Kim
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Publication number: 20130072985Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and an expansion medium for injection within or for filling the interior of the expandable member via the port. The methods involve the implantation of one or more devices or expandable spacers.Type: ApplicationFiled: May 1, 2012Publication date: March 21, 2013Applicant: Vertiflex, Inc.Inventor: Daniel H. Kim
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Publication number: 20130012998Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.Type: ApplicationFiled: April 9, 2012Publication date: January 10, 2013Applicant: VertiFlex, Inc.Inventors: Moti Altarac, Shawn Tebbe, Daniel H. Kim, J. Christopher Flaherty
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Publication number: 20120330359Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and a mechanical actuation means for expanding the expandable member or an expansion medium for injection within or for filling the interior of the expandable member via the port. The methods involve the implantation of one or more devices or expandable spacers.Type: ApplicationFiled: February 27, 2012Publication date: December 27, 2012Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Daniel H. Kim
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Patent number: 8317864Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and a mechanical actuation means for expanding the expandable member. The methods involve the implantation of one or more devices or expandable spacers.Type: GrantFiled: February 4, 2005Date of Patent: November 27, 2012Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Daniel H. Kim
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Publication number: 20120296431Abstract: Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the sagittal plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.Type: ApplicationFiled: July 31, 2012Publication date: November 22, 2012Applicant: SPINAL KINETICS, INC.Inventors: Daniel H. Kim, Thomas A. Afzal, Michael L. Reo, Uriel Hiram Chee, In Haeng Cho, Kunwoo Lee, Curtis W. Frank, Sun-Kyu Ha
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Publication number: 20120296166Abstract: A method for treating a patient includes inserting an endoscope into an intradural space of the patient via an interspace of a vertebral column of the patient; steering the endoscope along the intradural space to a location; and performing a medical procedure at the location using a working lumen of the endoscope.Type: ApplicationFiled: November 12, 2010Publication date: November 22, 2012Inventor: Daniel H. Kim
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Publication number: 20120283697Abstract: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.Type: ApplicationFiled: July 16, 2012Publication date: November 8, 2012Inventors: Daniel H. Kim, Mir A. Imran
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Publication number: 20120277839Abstract: Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.Type: ApplicationFiled: April 27, 2012Publication date: November 1, 2012Inventors: Jeffery M. Kramer, Daniel H. Kim, Mir A. Imran
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Patent number: 8277488Abstract: An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal caming surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the caming surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.Type: GrantFiled: July 24, 2008Date of Patent: October 2, 2012Assignee: VertiFlex, Inc.Inventors: Moti Altarac, Shawn Tebbe, Joey Camia Reglos, Yang Cheng, Murali P. Kadaba, Daniel H. Kim
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Patent number: 8273108Abstract: An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal caming surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the caming surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.Type: GrantFiled: July 8, 2008Date of Patent: September 25, 2012Assignee: VertiFlex, Inc.Inventors: Moti Altarac, Shawn Tebbe, Joey Camia Reglos, Yang Cheng, Murali P. Kadaba, Daniel H. Kim