Abstract: Provided are a method and systems for performing pulse oximetry. A light signal is emitted for a period of time and a modulated light signal is detected. The modulated light signal includes a red signal and an infrared signal. The modulated light signal is originated by an interaction of the light signal with a pulsatile tissue and a non-pulsatile tissue. The modulated light signal is processed to estimate an oxygen saturation in the pulsatile tissue during the period of time. The processing includes removing a non-pulsatile component resulting from the interaction of the light signal and the non-pulsatile tissue. The non-pulsatile component can be removed by removing a first parameter from an intensity of the infrared signal and a second parameter from an intensity of the red signal. The parameters are pre-determined using a calibration process to reproduce a true value for a ratio used to determine the oxygen saturation.

Abstract: A method and system for monitoring respiratory rate of a patient is provided. An example system includes a wearable device configured to be disposed around a wrist of the patient. The wearable device may include a gyroscope to measure a gyroscope signal indicative of a motion of the patient. The system may further include a processor communicatively coupled to the gyroscope. The processor can be configured to perform a spectral analysis of the gyroscope signal to obtain a spectrum in a pre-determined range. The pre-determined range may cover a normal respiratory rate range. The processor can be further configured to determine a position of a peak in the spectrum to obtain a value for the respiratory rate. The processor can be further configured to provide, based on the value of the respiratory rate, a message regarding a health status of the patient.

Abstract: A method and systems for determining an early warning score for a health status of a patient are provided. An example method includes acquiring, during a predetermined time period via sensors integrated into a wearable device worn on a wrist of the patient, initial values of medical parameters of patient. The medical parameters include a respiratory rate, oxygen saturation, temperature, blood pressure, and pulse rate, and level of consciousness. The method includes determining, based on the initial values, normal values of the medical parameters. The method includes acquiring, via the sensors and at a pre-determined frequency, further values of the medical parameters. The method includes determining, based on deviations of the further values from the normal values, individual scores for the medical parameters. The method includes calculating, based on the individual scores, a general score. The method includes determining, based on the general score, the health status of the patient.

Abstract: Provided are methods and systems for monitoring cardiac function. A series of heartbeat waveforms is collected during a pre-determined time period. The series is collected either from an individual or a plurality of individuals. A heartbeat waveform space is generated based on the series of heartbeat waveforms. A test heartbeat waveform is projected onto the heartbeat waveform space. The projected heartbeat waveform is subtracted from the test heartbeat waveform to obtain a pathology descriptive deflections (PDD) vector. A score is calculated based on the PDD vector. Based on the score, a clinical indication associated with at least one disease is provided. The clinical indication includes a warning message regarding an upcoming cardiac episode or a measure of progression or regression of at least one cardiac pathology.

Abstract: Electro-biometric data obtained from a user of a processor-based device may be used to authenticate that user. In some cases, no special action may need to be taken to initiate authentication.

Abstract: Provided are a method and systems for measuring an electrocardiogram (ECG) using a wearable device. An example system includes the wearable device in a shape of a band worn on a limb (e.g., a wrist) of a patient. The wearable device includes an electrical sensor. The wearable device is operable to record, via the at least one electrical sensor, an electrical signal from the limb of the patient. The wearable device is operable to split the electrical signal into segments based on a reference signal. The reference signal includes an indication of onset times of heart beats. The segments are averaged to derive average ECG data of low signal-to-noise ratio. The wearable device includes an optical sensor operable to measure skin color beneath a pulsating artery of the limb. The reference signal includes a photoplethysmogram (PPG) signal recorded via the optical sensor simultaneously with the electrical signal.

Abstract: A method and systems for monitoring health status of chronically ill people are provided. An example system includes a wearable device with sensors, with the wearable device being designed to be worn on a wrist of a patient. The wearable device is operable to continuously collect, via sensors, sensor data from a single place on body of the patient. The sensor data are processed to obtain electrocardiogram data and photoplethysmogram data. The electrocardiogram data and the photoplethysmogram data are analyzed to obtain medical parameters associated with a chronic disease. Based at least partially on the changes in the medical parameters over time, a progression of the at least one chronic disease can be determined. Based on the progression, messages regarding a current health condition are sent to the patient. The messages include advice to take medicine or contact a medical professional if a chronic condition is worsening.

Abstract: Provided are a method and systems for performing pulse oximetry. A light signal is emitted for a period of time and a modulated light signal is detected. The modulated light signal includes a red signal and an infrared signal. The modulated light signal is originated by an interaction of the light signal with a pulsatile tissue and a non-pulsatile tissue. The modulated light signal is processed to estimate an oxygen saturation in the pulsatile tissue during the period of time. The processing includes removing a non-pulsatile component resulting from the interaction of the light signal and the non-pulsatile tissue. The non-pulsatile component can be removed by removing a first parameter from an intensity of the infrared signal and a second parameter from an intensity of the red signal. The parameters are pre-determined using a calibration process to reproduce a true value for a ratio used to determine the oxygen saturation.

Abstract: Systems and methods for performing a blood pressure measurement are provided. An example method includes simultaneously recording, by a wearable device, an electrocardiogram (ECG) and photoplethysmogram (PPG). PPG is measured at a blood artery. The method also includes analyzing ECG and PPG to determine a pulse transit time (PTT), a pulse rate (PR), and a diameter parameter. The diameter parameter includes a diameter of the blood artery or a change thereof. The method also includes determining, based on PTT, PR, and the diameter parameter, a blood pressure (BP) using a pre-defined model. The pre-defined model establishes a relationship between PTT, PR, the diameter parameter, and BP. The pre-defined model may be trained using statistical data obtained in a calibration process. The statistical data includes PTT, PR, and the diameter parameter measured with the wearable device and corresponding values of BP measured with an external device.

Abstract: An example method for performing pulse oximetry can commence with receiving at least three light signals of three different wavelengths reflected from a human tissue. The human tissue includes a pulsatile tissue and a non-pulsatile tissue. Based on the three light signals, values of at least three functions are determined. The three functions are invariant to an oxygen saturation in the pulsatile tissue and depend on location of a sensor operable to detect the three light signals and pressure of the sensor on the human tissue. Based on the values of the three functions, non-pulsatile components are analyzed for intensities of a red light signal and infrared light signal reflected from the human tissue. The non-pulsated components are removed from the intensities to allow correct estimates of a ratio of the absorption coefficients, with the ratio being used to determine the oxygen saturation in the pulsatile tissue.

Abstract: Apparatus and methods are described, including apparatus for predicting an onset of a clinical episode. The apparatus includes a sensor, configured to sense at least one parameter of a subject substantially continuously during a period having a duration of at least one hour, and a control unit, configured to predict, at least one hour prior to the onset of the clinical episode, the onset at least in part responsively to the sensed parameter. Other applications are also described.

Abstract: Apparatus and methods are described, including apparatus for predicting an onset of a clinical episode. The apparatus includes a sensor, configured to sense at least one parameter of a subject substantially continuously during a period having a duration of at least one hour, and a control unit, configured to predict, at least one hour prior to the onset of the clinical episode, the onset at least in part responsively to the sensed parameter. Other applications are also described.

Abstract: A pair of contacts on a processor-based device may be used to collect two different types of human physiological data. That data may then be used to authenticate the user of such a device.

Abstract: Apparatus and methods are described, including a method for monitoring an onset of a respiratory episode in a subject. A plurality of respirations of the subject are sensed without contacting the subject, and a plurality of respiration signals corresponding to the plurality of respirations are generated. The plurality of respiration signals are combined to provide a characteristic respiration parameter of the subject. The onset of the respiratory episode is predicted from the characteristic respiration parameter. Other applications are also described.

Abstract: Apparatus and methods are described, including a method for treating a clinical episode. The method comprises sensing at least one parameter of a subject without contacting or viewing the subject or clothes the subject is wearing, analyzing the parameter, detecting the clinical episode at least in part responsively to the analysis, and responsively to detecting the clinical episode, treating the clinical episode using a device implanted in the subject. Other applications are also described.

Abstract: Apparatus and methods are described, including a method for monitoring an onset of a respiratory episode in a subject. A plurality of respirations of the subject are sensed without contacting the subject, and a plurality of respiration signals corresponding to the plurality of respirations are generated. The plurality of respiration signals are combined to provide a characteristic respiration parameter of the subject. The onset of the respiratory episode is predicted from the characteristic respiration parameter. Other applications are also described.

Abstract: A pair of contacts on a processor-based device may be used to collect two different types of human physiological data. That data may then be used to authenticate the user of such a device.

Abstract: Electro-biometric data obtained from a user of a processor-based device may be used to authenticate that user. In some cases, no special action may need to be taken to initiate authentication.

Abstract: A method of predicting an onset of apnea is described. Motion of a subject, including at least breathing-related motion, is sensed, and a signal corresponding to the sensed motion is generated. A breathing-related signal is extracted from the sensed motion signal, and the onset of apnea is predicted at least partially in response to analyzing the breathing-related signal. Other applications are also described.

Abstract: Apparatus and methods are provided for measuring a heartbeat of a fetus in a pregnant subject. A motion-related parameter of the pregnant subject is sensed without contacting or viewing the subject or clothes the subject is wearing. The fetal heartbeat is derived from the motion-related parameter, and an output is generated in response thereto. Other applications are also described.