Patents by Inventor Daniel H. S. Lee

Daniel H. S. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nogo Receptor Antagonists
    Publication number: 20080274112
    Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
    Type: Application
    Filed: January 30, 2004
    Publication date: November 6, 2008
    Inventors: Daniel H.S. Lee, R. Blake Pepinsky, Weiwei Li, Sylvia A. Rabacchi, Jane K. Relton, Dane S. Worley, Stephen M. Strittmatter, Dinah W.Y. Sah
  • Method for treating neurodegenerative disorders
    Patent number: 7018797
    Abstract: The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: March 28, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Allen B. Reitz, David A. Demeter, Daniel H. S. Lee, Hoau-Yan Wang, Robert H. Chen, Tina Morgan Ross, Malcolm K. Scott, Carlos R. Plata-Salaman
  • Method for treating neurodegenerative disorders
    Publication number: 20030130165
    Abstract: The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
    Type: Application
    Filed: June 5, 2002
    Publication date: July 10, 2003
    Inventors: Allen B. Reitz, David A. Demeter, Daniel H.S. Lee, Hoau-Yan Wang, Robert H. Chen, Tina Morgan Ross, Malcolm K. Scott, Carlos R. Plata-Salaman
  • Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
    Publication number: 20030092613
    Abstract: The present invention describes native and degenerate peptides derived from human &agr;7 nicotinic receptor useful as minimized ligands for &bgr; amyloid peptides. These peptides are useful to discover compounds that inhibit the interaction with &bgr; amyloid peptides with the &agr;7 nicotinic receptor, and are also useful in assays to measure &bgr; amyloid.
    Type: Application
    Filed: August 13, 2001
    Publication date: May 15, 2003
    Inventors: Daniel H. S. Lee, Hoau-Yan Wang, Carlos Plata-Salaman, Allen B. Reitz
  • Method of treating neurodegenerative disorders via inhibition of amyloid beta peptide binding
    Patent number: 6441049
    Abstract: The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: August 27, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Allen B. Reitz, David A. Demeter, Daniel H. S. Lee, Hoau-Yan Wang, Robert H. Chen, Tina Morgan Ross, Malcolm K. Scott, Carlos R. Plata-Salaman
  • 1,4-dithiin and 1,4-dithiepin-1,1,4,4, tetroxide derivatives useful as antagonists of the human galanin receptor
    Patent number: 6407136
    Abstract: The invention is directed to 1,4-dithiin- and 1,4-dithiepin-1,1,4,4-tetroxide derivatives useful as galanin receptor antagonists for treating disorders of the central nervous system. Pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions such as an eating disorder, obesity, bulimia nervosa, anorexia nervosa, binge eating, diabetes, dyslipidemia, hypertension, memory loss, sleep disturbances, pain, depression, anxiety, Alzheimer's disease, senile dementia, cerebral hemorrhage, or diarrhea are also described.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: June 18, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Malcolm K. Scott, Daniel H. S. Lee, Allen B. Reitz, Tina Morgan Ross, Haou-Yan Wang
  • METHOD OF TREATING NEURODEGENERATIVE DISORDERS VIA INHIBITION OF AMYLOID BETA PEPTIDE BINDING
    Publication number: 20020013374
    Abstract: The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
    Type: Application
    Filed: May 27, 1999
    Publication date: January 31, 2002
    Inventors: ALLEN B. REITZ, DAVID A. DEMETER, DANIEL H.S. LEE, HOAU-YAN WANG, ROBERT H. CHEN, TINA MORGAN ROSS, MALCOLM K. SCOTT, CARLOS R. PLATA-SALAMAN