Patents by Inventor Daniel Hans Rapoport

Daniel Hans Rapoport has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10208281
    Abstract: The invention relates to a method for cultivating cells in adhesion culture, comprising at least the following steps: a) dissolving or suspending a cross-linkable, biocompatible material having adhesion points for cells in a cell culture medium; b) suspending cells in the cell culture medium, which contains the cross-linkable, biocompatible material, or in a medium that contains at least one component that is required for the cross-linking of the cross-linkable, biocompatible material; c) introducing the cell suspension into a medium in drops under conditions that initiate or permit the cross-linking of the biocompatible material, wherein either the cell suspension or the medium into which the cell suspension is introduced in drops contains the cross-linkable biocompatible material; d) forming stable, preferably porous capsules from cross-linked biocompatible material, which capsules contain incorporated adherent cells; e) proliferating the adherent cells in the capsules for a specified time period; f) breaki
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: February 19, 2019
    Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Daniel Hans Rapoport, Miriam Voigt, Charlotte Walter
  • Publication number: 20160264931
    Abstract: The invention relates to a method for cultivating cells in adhesion culture, comprising at least the following steps: a) dissolving or suspending a cross-linkable, biocompatible material having adhesion points for cells in a cell culture medium; b) suspending cells in the cell culture medium, which contains the cross-linkable, biocompatible material, or in a medium that contains at least one component that is required for the cross-linking of the cross-linkable, biocompatible material; c) introducing the cell suspension into a medium in drops under conditions that initiate or permit the cross-linking of the biocompatible material, wherein either the cell suspension or the medium into which the cell suspension is introduced in drops contains the cross-linkable biocompatible material; d) forming stable, preferably porous capsules from cross-linked biocompatible material, which capsules contain incorporated adherent cells; e) proliferating the adherent cells in the capsules for a specified time period; f) breaki
    Type: Application
    Filed: September 22, 2014
    Publication date: September 15, 2016
    Inventors: Daniel Hans RAPOPORT, Miriam VOIGT, Charlotte WALTER
  • Publication number: 20150293012
    Abstract: The invention relates to a receptacle (4) for receiving a sample (5) during an optical analysis of the sample (5), wherein the receptacle (4) comprises a bottom (19) which is at least partially transparent so that the sample (5) within the receptacle (4) can be optically analyzed by an image sensor (6) from below the bottom (19) and wherein the bottom (19) is very thin thereby improving contrast and sharpness of the images generated by the image sensor (6). Further, the invention relates to a system for optically analyzing a sample (5).
    Type: Application
    Filed: November 9, 2012
    Publication date: October 15, 2015
    Inventors: Daniel Hans Rapoport, Tim Becker, Charli Kruse
  • Patent number: 8735151
    Abstract: The invention relates to an in vitro method for producing spontaneously contracting fish cell aggregates, to the fish cell aggregates obtained thereby, and to the use thereof, in particular for testing biological active substances and pharmaceuticals. The in vitro method according to the invention for producing contracting fish cell aggregates comprises the following steps: a) mechanical comminution and/or partial enzymatic digestion of fish embryos or fish larvae; b) transfer of the comminuted and/or partially digested fish tissue into an enzyme-free medium and removing the supernatant by centrifuging to obtain a cell pellet; c) re-suspension of the cell pellet in a cell culture medium; d) culturing the cells, with the medium being changed at least once, until spontaneously contracting cell aggregates form.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: May 27, 2014
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.
    Inventors: Charli Kruse, Bianka Grunow, Daniel Hans Rapoport, Philipp Ciba
  • Publication number: 20120171695
    Abstract: The invention relates to an in vitro method for producing spontaneously contracting fish cell aggregates, to the fish cell aggregates obtained thereby, and to the use thereof, in particular for testing biological active substances and pharmaceuticals. The in vitro method according to the invention for producing contracting fish cell aggregates comprises the following steps: a) mechanical comminution and/or partial enzymatic digestion of fish embryos or fish larvae; b) transfer of the comminuted and/or partially digested fish tissue into an enzyme-free medium and removing the supernatant by centrifuging to obtain a cell pellet; c) re-suspension of the cell pellet in a cell culture medium; d) culturing the cells, with the medium being changed at least once, until spontaneously contracting cell aggregates form.
    Type: Application
    Filed: September 8, 2010
    Publication date: July 5, 2012
    Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Charli Kruse, Bianka Grunow, Daniel Hans Rapoport, Philipp Ciba