Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The present disclosure provides systems and methods for controlling a welding machine comprising an electrode lead and a workpiece lead connectible to one of a plurality of welding platforms. An example method comprises determining if the workpiece lead is connected to a desired welding platform mounting a workpiece to be welded, and only applying a welding current to the electrode lead when the workpiece lead is connected to the desired welding platform. Determining if the workpiece lead is connected to the desired welding platform may comprise applying a probing current to the electrode lead and contacting the electrode lead to a workpiece mounted on one of the plurality of welding platforms, and monitoring current through ground connections of the welding platforms and determining that the workpiece lead is connected to the desired welding platform if less than a threshold current level is detected flowing through any ground connection.

Abstract: Disclosed is a system having a robotic welding apparatus configured to weld metal sections together along a seam, an input device configured to produce positioning input for the robotic welding apparatus while welding, and a controller configured to control the robotic welding apparatus in accordance with (i) a recording state in which operation of the robotic welding apparatus is controlled and recorded while welding in a root pass based on the positioning input to produce recorded positioning data, and (ii) an automatic state in which operation of the robotic welding apparatus is automatically controlled while welding in a subsequent pass based on the recorded positioning data. In accordance with an embodiment, motion of the robotic welding apparatus is selectively recorded such that the recorded positioning data utilized in the automatic state omits (i) initial transient motions of the robotic welding apparatus and/or (ii) stop-start motions of the robotic welding apparatus.

Abstract: A spline coupling comprises a male spline member having male spline teeth and a female spline member having female spline teeth complementary to and engaged with the male spline teeth. One or more of the female spline teeth has a tooth height lesser than a tooth height of another one or more of the female spline teeth. The tooth height of the one or more of the female spline teeth is defined by a top land surface of the one or more of the female spline teeth. The tooth height of the other one or more of the female spline teeth is defined by a top land surface of the other one or more of the female spline teeth. A drainage hole in the top land surface of the one or more of the female spline teeth passes through the one or more of the female spline teeth.

Abstract: A processing system includes a pseudo-random bit sequence (PRBS) control unit and a PRBS generator that is used to dynamically generate a PRBS from, for example, a first PRBS and a second PRBS. The PRBS generator is coupled to the PRBS control unit. The PRBS generator generates the second PRBS by dynamically adjusting from a first set of flip-flops of a master set of flip-flops that generate the first PRBS to a second set of flip-flops of the first master set of flip-flops that generate the second PRBS. The PRBS generator includes a plurality of PRBS logic engines coupled to a first PRBS multiplexer, the first PRBS multiplexer being used to select either the first PRBS or the second PRBS that is output by the PRBS generator.

Abstract: A monolithic joint system for a fuselage to wing joint in an aircraft is provided. The joint system comprises a first vertical flange, a base plate, a second vertical flange, and damage containment features associated with at least one of these components. The first vertical flange is configured to connect to a fuselage section of the aircraft and the second vertical flange is configured to connect to a rib web of a wing, while the base plate attaches outboard wing to inboard wing box. The first vertical flange, the base plate, and the second vertical flange are formed from a continuous piece of material. The damage containment features are configured to slow propagation of an active crack tip in the joint system during operation of the aircraft. Thus, the illustrative embodiments provide a one-piece joint system for the fuselage to wing joint of an aircraft.

Abstract: System, methods, and devices for measuring the performance of a component of a communications network recently installed by a technician using proactive network maintenance parameters, and further assessing the installation performed by the technician.

Abstract: A spline coupling comprises a male spline member having male spline teeth and a female spline member having female spline teeth complementary to and engaged with the male spline teeth. One or more of the female spline teeth has a tooth height lesser than a tooth height of another one or more of the female spline teeth. The tooth height of the one or more of the female spline teeth is defined by a top land surface of the one or more of the female spline teeth. The tooth height of the other one or more of the female spline teeth is defined by a top land surface of the other one or more of the female spline teeth. A drainage hole in the top land surface of the one or more of the female spline teeth passes through the one or more of the female spline teeth.

Abstract: A processing system includes a pseudo-random bit sequence (PRBS) control unit and a PRBS generator that is used to dynamically generate a PRBS from, for example, a first PRBS and a second PRBS. The PRBS generator is coupled to the PRBS control unit. The PRBS generator generates the second PRBS by dynamically adjusting from a first set of flip-flops of a master set of flip-flops that generate the first PRBS to a second set of flip-flops of the first master set of flip-flops that generate the second PRBS. The PRBS generator includes a plurality of PRBS logic engines coupled to a first PRBS multiplexer, the first PRBS multiplexer being used to select either the first PRBS or the second PRBS that is output by the PRBS generator.

Abstract: System, methods, and devices for measuring the performance of a component of a communications network recently installed by a technician using proactive network maintenance parameters, and further assessing the installation performed by the technician.

Abstract: Aircraft main landing gear drag brace backup fitting assemblies and related methods are described herein. An example aircraft wing disclosed herein includes a rear spar having a rear side and a front side opposite the rear side, a side-of-body rib coupled to the rear spar, a rib post disposed on the front side of the rear spar, where the rib post is to couple a second rib to the rear spar, a side-of-body fitting coupled to the side-of-body rib, an intercostal member coupled between the side-of-body fitting and the rib post, and a drag brace fitting disposed on the rear side of the rear spar. The drag brace fitting is coupled to the rib post and the side-of-body fitting via a first plurality of fasteners extending through the rear spar.

Abstract: A monolithic joint system for a fuselage to wing joint in an aircraft is provided. The joint system comprises a first vertical flange, a base plate, a second vertical flange, and damage containment features associated with at least one of these components. The first vertical flange is configured to connect to a fuselage section of the aircraft and the second vertical flange is configured to connect to a rib web of a wing, while the base plate attaches outboard wing to inboard wing box. The first vertical flange, the base plate, and the second vertical flange are formed from a continuous piece of material. The damage containment features are configured to slow propagation of an active crack tip in the joint system during operation of the aircraft. Thus, the illustrative embodiments provide a one-piece joint system for the fuselage to wing joint of an aircraft.

Abstract: System, methods, and devices for measuring the performance of a component of a communications network recently installed by a technician using proactive network maintenance parameters, and further assessing the installation performed by the technician.

Abstract: Aircraft main landing gear drag brace backup fitting assemblies and related methods are described herein. An example aircraft wing disclosed herein includes a rear spar having a rear side and a front side opposite the rear side, a side-of-body rib coupled to the rear spar, a rib post disposed on the front side of the rear spar, where the rib post is to couple a second rib to the rear spar, a side-of-body fitting coupled to the side-of-body rib, an intercostal member coupled between the side-of-body fitting and the rib post, and a drag brace fitting disposed on the rear side of the rear spar. The drag brace fitting is coupled to the rib post and the side-of-body fitting via a first plurality of fasteners extending through the rear spar.

Abstract: A system and method for the software and hardware-based management and control of overall energy consumption in a telecommunications network is described. The energy consumption management in broadband telecommunications networks is accomplished via an adaptive power system interface and network energy controller that has access to the energy management systems, subsystems, features, individual components and configurations of equipment and services within the network, and provides energy consumption control of an entire network or a portion thereof using a plethora of different types of equipment, equipment or software features, equipment cards, ports, devices, systems, and entire facilities within a network.

Abstract: A method and system for proactive network maintenance (PNM)-based onsite or remote evaluation of craft skills is provided. The method can be used in stand-alone manner or in conjunction with a local broadband services provider that uses PNM technology, and may be used to evaluate student or technician craft skills, as well as to develop a detailed catalog of craft flaws in order to facilitate better training and also facilitate better troubleshooting of actual network impairments.

Abstract: A system and method for the delivery of a medical device to a treatment location. The device may include an elongate body, the elongate body including a plurality of annular segments and a jacket disposed about the plurality of annular segments and defining an interior space, and a vacuum source in fluid communication with the interior space of the jacket. When a vacuum is applied to the interior space of the jacket, the jacket may constrict about the plurality of annular elements, thereby increasing the frictional forces between the plurality of segments and between the plurality of segments and an inner surface of the jacket.

Abstract: A system and method for the software and hardware-based management and control of overall energy consumption in a telecommunications network is described. The energy consumption management in broadband telecommunications networks is accomplished via an adaptive power system interface and network energy controller that has access to the energy management systems, subsystems, features, individual components and configurations of equipment and services within the network, and provides energy consumption control of an entire network or a portion thereof using a plethora of different types of equipment, equipment or software features, equipment cards, ports, devices, systems, and entire facilities within a network.

Abstract: A method and system for delivering coolant to a medical device having an expandable element, a guidewire lumen movable within the medical device, and an actuator element coupled to the guidewire lumen for manipulation of longitudinal movement thereof is provided, including transferring a fluid from a console to the medical device to inflate the expandable element; manipulating the actuator element, and initiating a predetermined fluid control sequence of the console in response to the manipulation of the actuator element.