Patents by Inventor Daniel Hoffmeyer

Daniel Hoffmeyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240118239
    Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.
    Type: Application
    Filed: December 15, 2023
    Publication date: April 11, 2024
    Inventors: Patrick Kinney, Sujata Iyer, Daniel Hoffmeyer, Manjeet Dhindsa, Tin Ngo, Tiffany Ding (Lay), Torleif Ove Björnson
  • Patent number: 11933760
    Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.
    Type: Grant
    Filed: September 1, 2022
    Date of Patent: March 19, 2024
    Assignee: TECAN TRADING AG
    Inventors: Patrick Kinney, Tin Ngo, Sujata Iyer, Daniel Hoffmeyer, Manjeet Dhindsa, Tiffany Ding (Lay)
  • Patent number: 11819845
    Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: November 21, 2023
    Assignee: TECAN TRADING AG
    Inventors: Thomas Perroud, Dan Tran, Daniel Hoffmeyer, Tiffany Lay, Manjeet Dhindsa
  • Patent number: 11774327
    Abstract: A sampling needle is provided for piercing a septum of a vial containing a sample and aspirating the sample from the vial. The needle may include: a tubular core having a lumen extending therethrough and a piercing end, wherein the tubular core is formed of a bioinert material; a hollow support encircling the tubular core with the piercing end extending outwardly from the support, wherein the support is formed of a rigid material; and a bioinert coating covering a portion of the support adjacent the piercing end, wherein the tubular core and the covering isolates the support from the sample.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: October 3, 2023
    Assignee: Dionex Corporation
    Inventors: Daniel Hoffmeyer, Licheng Tseng
  • Publication number: 20230204610
    Abstract: Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.
    Type: Application
    Filed: December 28, 2021
    Publication date: June 29, 2023
    Inventors: Daniel Hoffmeyer, Husam Al-Esawi, Tobias Metz, Til Richardsen, Christoph Hollnagel
  • Publication number: 20230204611
    Abstract: Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.
    Type: Application
    Filed: February 24, 2022
    Publication date: June 29, 2023
    Inventors: Daniel Hoffmeyer, Husam Al-Esawi, Tobias Metz, Til Richardsen, Christoph Hollnagel
  • Publication number: 20230003685
    Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.
    Type: Application
    Filed: September 1, 2022
    Publication date: January 5, 2023
    Applicant: TECAN TRADING AG
    Inventors: Patrick KINNEY, Tin Ngo, Sujata Iyer, Daniel Hoffmeyer, Manjeet Dhindsa, Tiffany Ding (Lay)
  • Publication number: 20220205876
    Abstract: A sampling needle is provided for piercing a septum of a vial containing a sample and aspirating the sample from the vial. The needle may include: a tubular core having a lumen extending therethrough and a piercing end, wherein the tubular core is formed of a bioinert material; a hollow support encircling the tubular core with the piercing end extending outwardly from the support, wherein the support is formed of a rigid material; and a bioinert coating covering a portion of the support adjacent the piercing end, wherein the tubular core and the covering isolates the support from the sample.
    Type: Application
    Filed: December 29, 2020
    Publication date: June 30, 2022
    Inventors: Daniel Hoffmeyer, Licheng Tseng
  • Publication number: 20210402401
    Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 30, 2021
    Applicant: TECAN TRADING AG
    Inventors: Thomas PERROUD, Dan TRAN, Daniel HOFFMEYER, Tiffany LAY, Manjeet DHINDSA
  • Patent number: 11148138
    Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: October 19, 2021
    Assignee: TECAN TRADING AG
    Inventors: Thomas Perroud, Dan Tran, Daniel Hoffmeyer, Tiffany Lay, Manjeet Dhindsa
  • Patent number: 10913062
    Abstract: Digital microfluidics system with electrodes attached to a PCB has control unit for manipulating liquid droplets by electrowetting, cartridge accommodation site for taking up a disposable cartridge having a working gap in-between two hydrophobic surfaces, and magnetic conduit/backing combination. A barrier element on an individual electrode of the PCB for narrowing the working gap. A disposable cartridge is positioned at the cartridge accommodation site, its flexible working film touching there and of the barrier element an uppermost surface. In the working gap and above a path of selected electrodes a liquid portion or liquid droplet with magnetically responsive beads moves by electrowetting on the electrode path until a magnetic field of the magnetic conduit is reached. The backing magnet is activated before and during the moving to thereby attract and remove magnetically responsive beads therefrom.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: February 9, 2021
    Assignee: TECAN TRADING AG
    Inventors: Thomas Perroud, Daniel Tran, Daniel Hoffmeyer, Tiffany Lay, Manjeet Dhindsa
  • Publication number: 20190331639
    Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.
    Type: Application
    Filed: April 25, 2018
    Publication date: October 31, 2019
    Applicant: TECAN TRADING AG
    Inventors: PATRICK KINNEY, Tin Ngo, Sujata Iyer, Daniel Hoffmeyer, Manjeet Dhindsa, Tiffany Ding (Lay)
  • Publication number: 20190331638
    Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.
    Type: Application
    Filed: April 25, 2018
    Publication date: October 31, 2019
    Applicant: TECAN TRADING AG
    Inventors: Patrick Kinney, Sujata Iyer, Daniel Hoffmeyer, Manjeet Dhindsa, Tin Ngo, Tiffany Ding (Lay), Torleif Ove Bjornson
  • Publication number: 20180339923
    Abstract: Digital microfluidics system with electrodes attached to a PCB has control unit for manipulating liquid droplets by electrowetting, cartridge accommodation site for taking up a disposable cartridge having a working gap in-between two hydrophobic surfaces, and magnetic conduit/backing combination. A barrier element on an individual electrode of the PCB for narrowing the working gap. A disposable cartridge is positioned at the cartridge accommodation site, its flexible working film touching there and of the barrier element an uppermost surface. In the working gap and above a path of selected electrodes a liquid portion or liquid droplet with magnetically responsive beads moves by electrowetting on the electrode path until a magnetic field of the magnetic conduit is reached. The backing magnet is activated before and during the moving to thereby attract and remove magnetically responsive beads therefrom.
    Type: Application
    Filed: September 1, 2016
    Publication date: November 29, 2018
    Applicant: TECAN TRADING AG
    Inventors: Thomas PERROUD, Dan TRAN, Daniel HOFFMEYER, Tiffany LAY, Manjeet DHINDSA
  • Patent number: 10137450
    Abstract: A disposable cartridge configured as a digital microfluidics system for manipulating samples in liquid portions having a cartridge accommodation site and a central control unit for controlling selection of individual electrodes of an electrode array located at the site and for providing plural electrodes with individual voltage pulses for manipulating liquid portions by electrowetting. The cartridge has a hydrophobic working surface and a rigid cover with a second hydrophobic surface, the hydrophobic surfaces facing each other and being separated in parallel planes by a gap. The cartridge has plural pipetting guides for safe entering/withdrawing liquids into/from the gap with a pipette tip. At least one of the pipetting guides provides an abutting surface sealingly admittable by a counter surface of a pipette tip, located at a pipetting orifice that reaches through the rigid cover, and configured to prevent a pipette tip from touching the hydrophobic working surface.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: November 27, 2018
    Assignee: TECAN TRADING AG
    Inventors: Tiffany Lay, Daniel Hoffmeyer, Anne R. Kopf-Sill
  • Publication number: 20180243743
    Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit.
    Type: Application
    Filed: September 2, 2015
    Publication date: August 30, 2018
    Applicant: TECAN TRADING AG
    Inventors: THOMAS PERROUD, Dan TRAN, Daniel HOFFMEYER, Tiffany LAY, Manjeet DHINDSA
  • Patent number: 9915631
    Abstract: A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: March 13, 2018
    Assignee: Tecan Trading AG
    Inventors: Daniel Hoffmeyer, Tiffany Lay, Travis Lee
  • Patent number: 9784711
    Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: October 10, 2017
    Assignee: TECAN TRADING AG
    Inventors: Daniel Hoffmeyer, Tiffany Lay, Travis Lee, Marc N. Feiglin, Werner Halg, Anne R. Kopf-Sill
  • Publication number: 20160082437
    Abstract: A cover (10) for use in a digital microfluidics system (16) for manipulating samples in liquid portions or droplets. The digital microfluidics system (16) includes a first substrate (18) with an array of electrodes (24) and a central control unit (20) for controlling the selection and for providing a number of the electrodes with voltage for manipulating liquid portions or droplets by electrowetting. A working gap (30) with a gap height is located parallel to the array of electrodes (24) and in-between first and second hydrophobic surfaces (26,28) that face each other at least during operation of the digital microfluidics system (16).
    Type: Application
    Filed: November 17, 2015
    Publication date: March 24, 2016
    Applicant: TECAN TRADING AG
    Inventors: Thomas PERROUD, Daniel HOFFMEYER, Adrian SAGER, Anne KOPF-SILL
  • Publication number: 20160016170
    Abstract: A disposable cartridge configured as a digital microfluidics system for manipulating samples in liquid portions having a cartridge accommodation site and a central control unit for controlling selection of individual electrodes of an electrode array located at the site and for providing plural electrodes with individual voltage pulses for manipulating liquid portions by electrowetting. The cartridge has a hydrophobic working surface and a rigid cover with a second hydrophobic surface, the hydrophobic surfaces facing each other and being separated in parallel planes by a gap. The cartridge has plural pipetting guides for safe entering/withdrawing liquids into/from the gap with a pipette tip. At least one of the pipetting guides provides an abutting surface sealingly admittable by a counter surface of a pipette tip, located at a pipetting orifice that reaches through the rigid cover, and configured to prevent a pipette tip from touching the hydrophobic working surface.
    Type: Application
    Filed: July 18, 2014
    Publication date: January 21, 2016
    Applicant: Tecan Trading AG
    Inventors: Tiffany LAY, Daniel HOFFMEYER, Anne R. KOPF-SILL