Patents by Inventor Daniel Horspool

Daniel Horspool has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene synthesis by convergent assembly of oligonucleotide subsets
    Patent number: 9068209
    Abstract: The invention provides a system and method for synthesizing polynucleotides by solid phase assembly oligonucleotide precursors, in accordance with the method, a polynucleotide is partitioned into an ordered set of subunits, wherein each subunit is assembled in a single reaction from a subset of oligonucleotide precursors that uniquely anneal together to produce the subunit. The subunits are then assembled to form the desired polynucleotide. An important feature of the invention is the selection of subunits that are free of undesired sequence elements, such as palindromes, repetitive sequences, and the like, which would result in more than one subunit product alter ligating a pool of oligonucleotide precursors.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: June 30, 2015
    Assignee: British Columbia Cancer Agency Branch
    Inventors: Robin Coope, Daniel Horspool, Robert A. Holt
  • GENE SYNTHESIS BY CONVERGENT ASSEMBLY OF OLIGONUCLEOTIDE SUBSETS
    Publication number: 20110287490
    Abstract: The invention provides a system and method for synthesizing polynucleotides by solid phase assembly oligonucleotide precursors, in accordance with the method, a polynucleotide is partitioned into an ordered set of subunits, wherein each subunit is assembled in a single reaction from a subset of oligonucleotide precursors that uniquely anneal together to produce the subunit. The subunits are then assembled to form the desired polynucleotide. An important feature of the invention is the selection of subunits that are free of undesired sequence elements, such as palindromes, repetitive sequences, and the like, which would result in more than one subunit product alter ligating a pool of oligonucleotide precursors.
    Type: Application
    Filed: May 12, 2009
    Publication date: November 24, 2011
    Inventors: Robin Coope, Daniel Horspool, Robert A. Holt