Patents by Inventor Daniel I. Oppenheimer

Daniel I. Oppenheimer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180256582
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Application
    Filed: May 8, 2018
    Publication date: September 13, 2018
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
  • Patent number: 9993481
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: June 12, 2018
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
  • Publication number: 20170000793
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Application
    Filed: April 6, 2016
    Publication date: January 5, 2017
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum, Augustus O. Okhamafe, Erik Foehr, Sianna Castillo, Paul John Kostel
  • Publication number: 20160367558
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Application
    Filed: September 2, 2016
    Publication date: December 22, 2016
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
  • Patent number: 9433624
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: September 6, 2016
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
  • Publication number: 20130237543
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Application
    Filed: February 6, 2013
    Publication date: September 12, 2013
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum, Augustus O. Okhamafe, Erik Foehr, Sianna Castillo, Paul John Kostel
  • Publication number: 20120108599
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 3, 2012
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
  • Patent number: 8067416
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: November 29, 2011
    Assignees: Merck Eprova AG, Biomarin Pharmaceutical Inc.
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
  • Publication number: 20110281880
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Application
    Filed: April 29, 2011
    Publication date: November 17, 2011
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum, Augustus Okhamafe, Erik Foehr, Sianna Castillo, Paul J. Kostel
  • Patent number: 7947681
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: May 24, 2011
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum, Augustus Okhamafe, Erik Foehr, Sianna Castillo, Paul J. Kostel
  • Publication number: 20100111918
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Application
    Filed: October 12, 2009
    Publication date: May 6, 2010
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum, Augustus Okhamafe, Erik Foehr, Sianna Castillo, Paul J. Kostel
  • Publication number: 20100009997
    Abstract: Low dose therapeutic methods for use of BH4 derivatives to treat BH4-responsive disorders, such as hyperphenylalanemia and neuropsychiatric diseases, and combination therapies of BH4 derivatives and other therapeutic regimens, are described.
    Type: Application
    Filed: January 14, 2008
    Publication date: January 14, 2010
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Alejandro Dorenbaum
  • Publication number: 20100009996
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Application
    Filed: July 23, 2009
    Publication date: January 14, 2010
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
  • Patent number: 7612073
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: November 3, 2009
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum
  • Patent number: 7566714
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: July 28, 2009
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
  • Publication number: 20090076014
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Application
    Filed: December 8, 2008
    Publication date: March 19, 2009
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum
  • Publication number: 20090018136
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention of vascular complications associated with diabetes, hyperlipidemias, and various cardiovascular disorders including but not limited to recalcitrant hypertension, coronary artery disease, pulmonary arterial hypertension, congestive heart failure, and hemolytic anemias. More specifically, the specification describes methods and compositions for treating such vascular disorders using compositions comprising BH4 and derivative thereof. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Application
    Filed: June 5, 2008
    Publication date: January 15, 2009
    Inventors: Daniel I. Oppenheimer, Emil D. Kakkis, Alejandro Dorenbaum
  • Patent number: RE43797
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: November 6, 2012
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum, Augustus O. Okhamafe