Patents by Inventor Daniel Isom

Daniel Isom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240175876
    Abstract: Disclosed herein are engineered yeast cells, systems, and methods for screening for a ligand that modulates a receptor function and for determining functional consequences of receptor-ligand binding.
    Type: Application
    Filed: November 29, 2023
    Publication date: May 30, 2024
    Inventors: Daniel Isom, Jacob Rowe
  • Publication number: 20230053864
    Abstract: The disclosure relates to a plurality of cells, compositions and methods for identifying modulators of a target protein. The cells, compositions and methods comprise a (i) a target domain gene (ii) an intracellular chimeric G-protein alpha subunit comprising an endogenous G-protein alpha subunit with a humanized C-terminus; and (iii) an inducible reporter, wherein the expression of the reporter is dependent on the activation of the target domain encoded by target domain gene, and wherein the target domain gene comprises a barcode. The disclosure further relates to a host cell comprising a plurality of exogenous landing pads integrated in the host cell's genome, wherein each exogenous landing pad is integrated at a safe harbor genome loci in the host cell's genome.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 23, 2023
    Inventors: Daniel Isom, William Morgan, Nicholas Kapolka, Geoffrey Taghon, Jacob Rowe