Abstract: This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.

Abstract: The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated.

Abstract: A truss structure well suited for use as an engine strut on a commercial aircraft. The truss structure is cast as a single piece integrally formed component from a titanium alloy or another suitably lightweight, structurally strong material. The truss structure includes a plurality of integrally formed attachment structures which enable the truss structure to be secured to an element of an aircraft such as a wing. A plurality of attachment areas for an element such as an engine is also formed that allows the element (e.g. jet engine) to be secured to the truss structure. The truss structure includes a plurality of elongated rails and truss elements that are arranged to provide redundant load paths to ensure that a failure of any one truss element or elongated rail will not result in a failure of the overall truss structure to support whatever load is required.

Abstract: A truss structure well suited for use as an engine strut on a commercial aircraft. The truss structure is cast as a single piece integrally formed component from a titanium alloy or another suitably lightweight, structurally strong material. The truss structure includes a plurality of integrally formed attachment structures which enable the truss structure to be secured to an element of an aircraft such as a wing. A plurality of attachment areas for an element such as an engine is also formed that allows the element (e.g. jet engine) to be secured to the truss structure. The truss structure includes a plurality of elongated rails and truss elements that are arranged to provide redundant load paths to ensure that a failure of any one truss element or elongated rail will not result in a failure of the overall truss structure to support whatever load is required.