Patents by Inventor Daniel J. B. Williams

Daniel J. B. Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 10214774
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: February 26, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Peter Williams, Daniel J. B. Williams, Linda Bloom, Thomas J. Taylor
  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 10208341
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: February 19, 2019
    Assignee: Life Technologies Corporation
    Inventors: Peter Williams, Daniel J. B. Williams, Linda Bloom, Thomas J. Taylor
  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 9458500
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: June 8, 2013
    Date of Patent: October 4, 2016
    Assignee: Life Technologies Corporation
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 9096898
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: August 4, 2015
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
  • Method of Determining the Nucleotide Sequence of Oligonucleotides and DNA Molecules
    Publication number: 20140342365
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 20, 2014
    Applicant: Life Technologies Corporation
    Inventors: Peter Williams, Daniel J.B. Williams, Linda Bloom, Thomas J. Taylor
  • Method of Determining the Nucleotide Sequence of Oligonucleotides and DNA Molecules
    Publication number: 20140335509
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 13, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Peter Williams, Daniel J.B. Williams, Linda Bloom, Thomas J. Taylor
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20130295560
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: June 8, 2013
    Publication date: November 7, 2013
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20130288235
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: May 14, 2013
    Publication date: October 31, 2013
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20120258449
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: February 29, 2012
    Publication date: October 11, 2012
    Applicant: ARIZONA BOARD OF REGENTS
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 8263364
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: September 11, 2012
    Assignee: Arizona Board of Regents
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 8263365
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: September 11, 2012
    Assignee: Arizona Board of Regents
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
  • Method of determining the nucleotide sequence of Oligonucleotides and DNA molecules
    Patent number: 8216514
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: July 10, 2012
    Assignee: Arizona Board of Regents
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20120015353
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: June 8, 2011
    Publication date: January 19, 2012
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20110294115
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: May 3, 2011
    Publication date: December 1, 2011
    Applicant: ARIZONA BOARD OF REGENTS
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20110183322
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 28, 2011
    Applicant: ARIZONA BOARD OF REGENTS
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20110183321
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: December 16, 2010
    Publication date: July 28, 2011
    Applicant: ARIZONA BOARD OF REGENTS
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20110183323
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 28, 2011
    Applicant: ARIZONA BOARD OF REGENTS
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 7875440
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: January 25, 2011
    Assignee: Arizona Board of Regents
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
  • METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
    Publication number: 20100209922
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Application
    Filed: November 13, 2009
    Publication date: August 19, 2010
    Applicant: ARIZONA BOARD OF REGENTS
    Inventors: PETER WILLIAMS, THOMAS J. TAYLOR, DANIEL J.B. WILLIAMS, IAN GOULD, MARK A. HAYES
  • Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
    Patent number: 7645596
    Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA poly-merase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: January 12, 2010
    Assignee: Arizona Board of Regents
    Inventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes