Patents by Inventor Daniel J. Delecki

Daniel J. Delecki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unsymmetrical complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods
    Patent number: 6248870
    Abstract: A method for diagnostic imaging a site in a patient. The method involves the use of an immunoreactive group which is linked to an unsymmetrical oligo-2,6-pyrimidine complexing agent.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: June 19, 2001
    Assignee: Nycomed Imaging AS
    Inventors: Daniel J. Delecki, Ashis Kumar Saha, Robert A. Snow
  • Unsymmetrical complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods
    Patent number: 5817774
    Abstract: Described are novel, unsymmetrical oligo-2,6-pyridine complexing agents. Also described are metal chelates and targeting immunoreagents containing such completing agents as well as diagnostic and therapeutic compositions containing such immunoreagents and diagnostic and therapeutic methods of using the immunoreagents.
    Type: Grant
    Filed: September 24, 1996
    Date of Patent: October 6, 1998
    Assignee: Sterling Winthrop Incorporation
    Inventors: Daniel J. Delecki, Ashis Kumar Saha, Robert A. Snow
  • Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods
    Patent number: 5760191
    Abstract: A metal chelate comprising a compound having the following formula and one or more metal ions which metal ions are a radionucleotide or a paramagnetic metal ion: ##STR1##
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: June 2, 1998
    Assignee: Nycomed Imaging AS
    Inventors: Robert A. Snow, Daniel J. Delecki, Chandra R. Shah
  • Acyclic nucleoside analogs and oligonucleotide sequences containing them
    Patent number: 5576427
    Abstract: Compounds of formula I; ##STR1## wherein R.sup.1 is hydrogen, or a blocking group that is compatible with oligonucleotide synthesis;R.sup.2 is hydrogen, nitro, lower alkyl amino, diloweralkyl amino or methyl;R.sup.3 is hydrogen or --P(R.sup.4)OR.sup.5 ;R.sup.4 is chlorine, 4-nitroimidazole, imidazole, tetrazole, triazole or di(lower-alkyl)amino-;R.sup.5 is methyl, 2-cyanoethyl or 2,2,2-trichloroethyl;n is from 0 to 2X is oxygen, sulfur, or --NR.sup.6 ;R.sup.6 is hydrogen or lower alkyl;Q is chosen from the group consisting of ##STR2## R.sup.7 is lower-alkyl or loweralkyloxy methylene; and R.sup.8 is hydrogen, benzoyl, anisoyl, or lower-alkyl carbonyland its pharmaceutically acceptable addition salts are nucleotide analogs. Modified oligonucleotides containing the nucleoside analogs of formula I are stable to nuclease degradation and are useful in inhibiting gene expression, in sequencing, and in mutagenesis.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: November 19, 1996
    Assignee: Sterling Winthrop, Inc.
    Inventors: Philip D. Cook, Daniel J. Delecki, Charles Guinosso
  • Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods
    Patent number: 5559214
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: September 24, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Daniel J. Delecki, Ashis K. Saha, Robert A. Snow
  • 2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines
    Patent number: 5539117
    Abstract: The present invention is directed to 2-acetyl-6-cyanopyridine compounds that are useful as intermediates in the synthesis of oligo-2,6-pyridines. The present invention is also directed to new, simpler, less expensive methods for synthesizing such oligopyridines using the novel 2-acetyl-6-cyanopyridine compounds as intermediates.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: July 23, 1996
    Inventors: Robert A. Snow, Daniel J. Delecki, Chandra R. Shah, K. Robert Hollister
  • 2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines
    Patent number: 5350696
    Abstract: The present invention is directed to 2-acetyl-6-cyanopyridine compounds that are useful as intermediates in the synthesis of oligo-2,6-pyridines. The present invention is also directed to new, simpler, less expensive methods for synthesizing such oligopyridines using the novel 2-acetyl-6-cyanopyridine compounds as intermediates.
    Type: Grant
    Filed: April 13, 1993
    Date of Patent: September 27, 1994
    Assignee: Sterling Winthrop, Inc.
    Inventors: Robert A. Snow, Daniel J. Delecki, Chandra R. Shah, K. Robert Hollister
  • Anti-ulcer methano-dibenzazocines derivatives
    Patent number: 4129561
    Abstract: 5,6,7,12-Tetrahydro-5,12-methanodibenz[c,f]azocines substituted in the 6-position by a di(lower)alkylaminoacetyl or a di(lower)alkylaminoethyl group inhibit stress-induced ulcers. Also described are intermediates and processes for preparing the anti-ulcer compounds.
    Type: Grant
    Filed: July 20, 1977
    Date of Patent: December 12, 1978
    Assignee: American Home Products Corporation
    Inventors: Reinhardt P. Stein, Daniel J. Delecki