Patents by Inventor Daniel J. Dwyer
Daniel J. Dwyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10343156Abstract: Described are pipettes capable of dispensing both high volumes of liquid and highly accurate smaller volumes of liquid wherein the accuracy of the volume of liquid delivered increases along the length of the pipette. Embodiments of the pipette include an elongated body with an outer surface, an inner surface defining a lumen within the elongated body, a proximal orifice at a proximal end, a distal orifice at a distal end. The intermediate portion includes a first generally frustoconical-shaped portion defined by a first inner diameter proximate the proximal end of the elongated body and a second inner diameter proximate a second end thereof. In an embodiment, the intermediate portion includes a second generally frustoconical-shaped portion defined by a third inner diameter proximate the transition to the first portion and a fourth inner diameter adjacent the distal end of the elongated body.Type: GrantFiled: March 15, 2013Date of Patent: July 9, 2019Assignee: Nalge Nunc International CorporationInventors: John M. Staton, Daniel J. Dwyer
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Patent number: 10208312Abstract: The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5? untranslated region (5? UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5? UTR of an mRNA.Type: GrantFiled: November 30, 2016Date of Patent: February 19, 2019Assignee: TRUSTEES OF BOSTON UNIVERSITYInventors: James J. Collins, Farren J. Isaacs, Charles R. Cantor, Daniel J. Dwyer
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Publication number: 20180142247Abstract: The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5? untranslated region (5? UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5? UTR of an mRNA.Type: ApplicationFiled: November 30, 2016Publication date: May 24, 2018Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: James J. Collins, Farren J. Isaacs, Charles R. Cantor, Daniel J. Dwyer
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Patent number: 9534224Abstract: The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5? untranslated region (5? UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5? UTR of an mRNA.Type: GrantFiled: November 14, 2003Date of Patent: January 3, 2017Assignee: Trustees of Boston UniversityInventors: James J. Collins, Farren J. Isaacs, Charles R. Cantor, Daniel J. Dwyer
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Publication number: 20140260697Abstract: Described are pipettes capable of dispensing both high volumes of liquid and highly accurate smaller volumes of liquid wherein the accuracy of the volume of liquid delivered increases along the length of the pipette. Embodiments of the pipette include an elongated body with an outer surface, an inner surface defining a lumen within the elongated body, a proximal orifice at a proximal end, a distal orifice at a distal end. The intermediate portion includes a first generally frustoconical-shaped portion defined by a first inner diameter proximate the proximal end of the elongated body and a second inner diameter proximate a second end thereof. In an embodiment, the intermediate portion includes a second generally frustoconical-shaped portion defined by a third inner diameter proximate the transition to the first portion and a fourth inner diameter adjacent the distal end of the elongated body.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: John M. Staton, Daniel J. Dwyer
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Patent number: 8366371Abstract: A battery movement, storage, and charging system for large size batteries used in lift trucks includes spaced, parallel storage racks, each of which have multiple storage and charging bays. A battery transport tower is positioned in an aisle between the storage racks and is moveable horizontally between the two rows of racks. The tower includes an extendable fork lift mounted which may rotate around the axis of the tower as well as move vertically upwardly or downwardly on the tower. A battery exchanger loads a discharged battery from a lift truck, places it on a pallet and then transfers the pallet and battery to a transfer bay in a storage rack where the tower forklift moves a pallet and battery to a selected charging bay.Type: GrantFiled: November 30, 2007Date of Patent: February 5, 2013Assignee: Sacket Material Handling Systems, Inc.Inventors: Leonard J. Maniscalco, Paul R. Egger, Daniel J. Dwyer
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Publication number: 20090139940Abstract: A battery movement, storage, and charging system for large size batteries used in lift trucks includes spaced, parallel storage racks, each of which have multiple storage and charging bays. A battery transport tower is positioned in an aisle between the storage racks and is moveable horizontally between the two rows of racks. The tower includes an extendable fork lift mounted which may rotate around the axis of the tower as well as move vertically upwardly or downwardly on the tower. A battery exchanger loads a discharged battery from a lift truck, places it on a pallet and then transfers the pallet and battery to a transfer bay in a storage rack where the tower forklift moves a pallet and battery to a selected charging bay.Type: ApplicationFiled: November 30, 2007Publication date: June 4, 2009Applicant: Sackett Material Handling Systems, Inc.Inventors: Leonard J. Maniscalco, Paul R. Egger, Daniel J. Dwyer
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Patent number: 6773898Abstract: A process challenge device and method of using the same is presented for testing the efficiency of various sterilization procedures on objects to be sterilized. The device is assembled from two tapered end portions having opposite open ends and an open pathway extending therethrough. A central chamber in the open pathway receives a Biological Indicator for testing the efficiency of the sterilization process. The device is ideal for testing a sterilization process on elongated objects such as tubing, at any point along their length. The coupling structures on the end portions provide the device with single-use security.Type: GrantFiled: September 9, 2002Date of Patent: August 10, 2004Assignee: Raven Biological Laboratories, Inc.Inventors: Russell Nyberg, Daniel J. Dwyer, Robert V. Dwyer, Jr.
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Patent number: D731075Type: GrantFiled: March 15, 2013Date of Patent: June 2, 2015Assignee: Nalge Nunc International CorporationInventors: John M. Staton, Daniel J. Dwyer
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Patent number: D787698Type: GrantFiled: January 23, 2015Date of Patent: May 23, 2017Inventors: John M. Staton, Daniel J. Dwyer