Patents by Inventor Daniel J. Finley
Daniel J. Finley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11961598Abstract: A method for predicting errors in prescription claim data is performed by a claim analysis device. The method includes extracting historical claim features from successfully processed historical claims received from the data warehouse system. The method includes extracting pending claim features from a pending claim. The method includes applying a binarization process on the extracted historical claim features to obtain a binarized training feature set. The method includes applying the binarization process on the extracted pending claim features to obtain a binarized pending feature set. The method includes calculating an aggregate distance between the binarized pending feature set and the binarized training feature set. The method includes identifying the historical claim associated with the least aggregate distance as a predictive historical claim.Type: GrantFiled: June 26, 2020Date of Patent: April 16, 2024Assignee: Express Scripts Strategic Development, Inc.Inventors: Morgan J. Finley, Garret L. Anderson, Camille Patel, Michael Nassar, Siju Vattakunnumpurath Eugin, Daniel Owens
-
Patent number: 10351568Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.Type: GrantFiled: November 5, 2015Date of Patent: July 16, 2019Assignee: President and Fellows of Harvard CollegeInventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min Jae Lee, Timothy C. Gahman
-
Publication number: 20180265519Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.Type: ApplicationFiled: May 21, 2018Publication date: September 20, 2018Inventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min J. Lee, Timothy C. Gahman
-
Patent number: 9981981Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.Type: GrantFiled: December 17, 2014Date of Patent: May 29, 2018Assignee: President and Fellows of Harvard CollegeInventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min J. Lee, Timothy C. Gahman
-
Patent number: 9849135Abstract: Disclosed herein are methods of treating or preventing a viral infection resulting from infection by a flavivirus, comprising administering to a subject a small molecule inhibitor of USP14, represented by Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, chemically-protected form, enantiomer or stereoisomer thereof, and pharmaceutical compositions comprising an effective amount of a compound of Formula (I) for use in the method.Type: GrantFiled: January 25, 2013Date of Patent: December 26, 2017Assignees: President and Fellows of Harvard College, Health Research, Inc.Inventors: Daniel J. Finley, Dilip Nag, Laura D. Kramer
-
Publication number: 20160214989Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.Type: ApplicationFiled: November 5, 2015Publication date: July 28, 2016Inventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min Jae Lee, Timothy C. Gahman
-
Publication number: 20160039839Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.Type: ApplicationFiled: December 17, 2014Publication date: February 11, 2016Inventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min J. Lee, Timothy C. Gahman
-
Patent number: 9201073Abstract: This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14.Type: GrantFiled: September 10, 2013Date of Patent: December 1, 2015Assignee: President and Fellows of Harvard CollegeInventors: Daniel J. Finley, John W. Hanna, Nathaniel A. Hathaway, Randall W. King, Byung-Hoon Lee
-
Publication number: 20150335652Abstract: Disclosed herein are methods of treating or preventing a viral infection resulting from infection by a flavivirus, comprising administering to a subject a small molecule inhibitor of USP14, represented by Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, chemically-protected form, enantiomer or stereoisomer thereof, and pharmaceutical compositions comprising an effective amount of a compound of Formula (I) for use in the method.Type: ApplicationFiled: January 25, 2013Publication date: November 26, 2015Inventors: Daniel J. Finley, Dilip Nag, Laura D. Kramer
-
Patent number: 8933087Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.Type: GrantFiled: July 22, 2011Date of Patent: January 13, 2015Assignee: President and Fellows of Harvard CollegeInventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min J. Lee, Timothy C. Gahman
-
Publication number: 20140275169Abstract: Disclosed herein are combination therapies for enhancing protein degradation. One component is an inhibitor of USP14, while the second component is an inhibitor of Hsp70. In certain embodiments, the invention relates to methods of treating or preventing a tauopathy, such as Alzheimer's disease.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicants: The Regents of the University of Michigan, President and Fellows of Harvard CollegeInventors: Daniel J. Finley, Jessica Robert, Monica Boselli, Jason E. Gestwicki, Xiaokai Li
-
Publication number: 20140199706Abstract: This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14.Type: ApplicationFiled: September 10, 2013Publication date: July 17, 2014Applicant: President and Fellows of Harvard CollegeInventors: Daniel J. Finley, John W. Hanna, Nathaniel A. Hathaway, Randall W. King, Byung-Hoon Lee
-
Publication number: 20130210845Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.Type: ApplicationFiled: July 22, 2011Publication date: August 15, 2013Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min J. Lee, Timothy C. Gahman
-
Publication number: 20130045992Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.Type: ApplicationFiled: January 28, 2011Publication date: February 21, 2013Applicant: President and Fellows of Harvard CollegeInventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min J. Lee, Timothy C. Gahman
-
Patent number: 7853498Abstract: The present invention provides a method, system, and computer program product for the on-demand creation and distribution of customized dynamic contracts. At least one business opportunity is extracted from an opportunity database. For each extracted business opportunity, a credit score for a customer associated with the extracted business opportunity is obtained and a dynamically modifiable contract for the extracted business opportunity is generated. The dynamically modifiable contract is distributed to a contact associated with the extracted business opportunity, who presents the dynamically modifiable contract to the customer associated with the extracted business opportunity. The contact can modify the dynamically modifiable contract, if necessary, during negotiations with the customer, to provide a contract that is acceptable to the contact and the customer.Type: GrantFiled: November 3, 2005Date of Patent: December 14, 2010Assignee: International Business Machines CorporationInventors: Daniel J. Finley, Louis Guglielmo, William M. Houston, Martina L. Kim, Randy B. Klipstein, Joseph L. Simons, Christian Toft-Nielsen