Abstract: Methods of treating, reducing the risk of, preventing, or alleviating a symptom of inflammation or inflammatory gastrointestinal disease by administration of a modified bacterium providing purines, in particular hypoxanthine, to the mucosa of the intestine, and compositions containing modified bacteria useful in such methods.

Abstract: A capsularhexis electrode device and corresponding insertion tool are disclosed. A flexible capsulorhexis electrode device comprises an elastomeric ring, first and second electrically conductive traces disposed at a first face of the elastomeric ring and extending concentrically around the elastomeric ring, and first and second electrically conductive connectors. The first and second electrically conductive connectors are electrically connected to the first and second traces, respectively, and are disposed at opposing points across the elastomeric ring from one another. An insertion tool includes first and second stretcher bars with connectors for mating to the electrode device. One of the stretcher bars translates relative to the other to elongate the flexible electrode device for insertion into the anterior chamber of the eye through a small incision.

Abstract: In various embodiments, an ophthalmic handpiece may include a handpiece body with a pulse chamber and flooded engine compartment configured to receive fluid from a surgical console through a fluid inlet port. Heated pulses from the pulse chamber and cooler fluid from the flooded engine compartment may flow through a tip into the eye. In some embodiments, the tip may be a dual lumen tip that keeps the flows from the pulse chamber and flooded engine compartment separate until they exit the tip. In some embodiments, a tip, coupled to a merging chamber where the flows may merge prior to the tip, may be a single lumen tip that directs the heated pulses and irrigation fluid simultaneously to a lens to liquefy the lens for removal from the eye.

Abstract: A capsularhexis electrode device and corresponding insertion tool are disclosed. A flexible capsulorhexis electrode device comprises an elastomeric ring, first and second electrically conductive traces disposed at a first face of the elastomeric ring and extending concentrically around the elastomeric ring, and first and second electrically conductive connectors. The first and second electrically conductive connectors are electrically connected to the first and second traces, respectively, and are disposed at opposing points across the elastomeric ring from one another. An insertion tool includes first and second stretcher bars with connectors for mating to the electrode device. One of the stretcher bars translates relative to the other to elongate the flexible electrode device for insertion into the anterior chamber of the eye through a small incision.