Abstract: The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e.g. cobalamin and its analogs). The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin (e.g. cobalamin drug conjugates).

Abstract: The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e.g. cobalamin and its analogs). The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin (e.g. cobalamin drug conjugates).

Abstract: The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e.g. cobalamin and its analogs). The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin (e.g. cobalamin drug conjugates).

Abstract: The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e.g. cobalamin and its analogs). The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin (e.g. cobalamnin drug conjugates).

Abstract: All-season radial-ply pneumatic tire for passenger and light truck vehicles. A rubber tread is positioned radially outwardly of a carcass ply and belt structure. The tread has grooves that define blocks of rubber spaced apart circumferentially around the tread. Circumferentially-spaced corners of the rubber blocks are chamfered toward the respective bottoms of the grooves, thereby, to increase their respective stiffnesses to improve their uniformity of wear and also to reduce the amplitude of sound frequencies generated by the tire in normal use.

Abstract: A tread portion for a pneumatic tire is divided axially across its width into three zones. A pair of lateral edge portions cooperate to provide a directional tread pattern, while a central portion of the tread has a non-directional tread pattern.

Abstract: A pneumatic radial passenger tire having a ground-engaging tread portion and a pair of axially opposed tread edges. The tread portion comprising at least two circumferentially continuous grooves formed by alternately disposed axially and circumferentially extending segments. Each of the segments have a particular angle orientation. There is also provided additional grooves connecting the circumferentially extending grooves and which extend from the axially outer circumferential grooves to the tread edge.

Abstract: A pneumatic radial tire having a tread portion comprising a first plurality of grooves, the grooves in the central region of the tread following a particular path across the tread. The grooves are spaced circumferentially apart a distance of about 2 to 3% of the circumference of the outer surface of the tread. A second plurality of grooves are provided in the central portion each of which follow substantially the same path as the first plurality of grooves and are substantially the mirror images of the first plurality of grooves. The second plurality of main grooves are also spaced circumferentially apart a distance in the range of about 2 to 3% of the circumference of the tire.

Abstract: A tread capable of being used in all seasons and weather conditions comprising of a substantially centrally located rib which extends circumferentially about the tire, a plurality of independent projections placed about the remaining portion of the tire. The independent projections are placed so as to provide for two circumferentially extending grooves, one on either side of the central rib and a plurality of laterally extending grooves which extend from each central groove to the tread edge of the tire. The tread has a low net to gross ratio.

Abstract: A tread for a pneumatic tire having a plurality of circumferentially spaced independent projections. The tread has three narrow zones which extend circumferentially about the tire; a central zone and two shoulder zones. The depth of the recesses in between the independent projections in these zones is substantially less than the depth of the recesses in between the projections in the remaining portion of the tread.

Abstract: A tread for a pneumatic tire having a plurality of circumferentially spaced independent projections, each projection has an outer configuration which is basically triangular as viewed in a plane perpendicular to the tread. The projections in the central portion of the tread are oriented such that the leading edges form an angle from about 30.degree. to 60.degree. with respect to the mid-circumferential plane of the tire, and the projections in the shoulder portions are oriented such that the leading edges form an angle from about 30.degree. to 70.degree. with respect to the mid-circumferential plane of the tire.

Abstract: Using a decor strip of white, or other contrasting, compound not greater than about 2 millimeters thickness, two ribs and an intervening annular groove lined with the strip are formed on a tire sidewall. The strip is cured integrally with the ribs and sidewall and in direct contact with the mold, without the customary overlay of black rubber. The tire so formed has no white rubber beneath any black rubber in the tire. The quantity of white compound required is materially reduced.The foregoing abstract is not to be taken as limiting the invention of this application, and in order to understand the full nature and extent of the technical disclosure of this application, reference must be made to the accompanying drawing and the following detailed description.