Abstract: Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of fasting blood glucose levels and may ameliorate (e.g.

Abstract: Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of fasting blood glucose levels and may ameliorate (e.g.

Abstract: Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of fasting blood glucose levels and may ameliorate (e.g.

Abstract: Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.

Abstract: Method, product and system alters audio data for a synthesized voice so that when it is produced on a speaker system, it appears to emanate from a spatial position. First, the voice is synthesized into a speech waveform from a set of stored data representative of a text string using standard techniques. The speech waveform is converted into analog signals for a right and left channel. According to the invention, the analog signals to the right and left channels are altered according to position data stored with the text string so that the synthesized voice appears to originate at the apparent spatial position when the analog signals are sent to a speaker system.

Abstract: A technique for producing a sound of a plurality of a selected instrument from a digitized audio sample of the selected instrument. The digitized audio sample of the single selected instrument is stored in a memory. Next, copies of the digitized audio sample are micromanipulated in parallel in a plurality of digital processors corresponding in number to the plurality of the selected instrument. Each of the digital processors processes the digital audio sample in a slightly different time variant manner to produce the effect of a plurality of instruments. The processed digital audio samples are summed into a single digital sample. The summed digital audio sample is converted to an analog signal which is sent to a speaker to produce the sound of the plurality of the selected instrument.

Abstract: A drainage catheter for draining fluids from an internal body part and a process of using the catheter wherein the catheter is subject to development of encrustations of the fluids being drained. The catheter comprises an outer flexible tubular member with a drainage lumen disposed therein. An inner flexible tubular member is slidably disposed within the outer tubular member. The inner tubular member is positioned in the outer tubular member in a predetermined location relative to the outer tubular member whereby withdrawal of the inner tubular member can cause encrustations to be broken up and removed without withdrawing the catherer from the body part being drained.

Abstract: A method and system for automatically generating an entire musical arrangement including melody and accompaniment on a computer. The invention combines predetermined, short musical phrases modified by selection of random parameters to produce a data stream that can be used to drive a MIDI synthesizer and generate music.

Abstract: A method and apparatus are disclosed for the audio editing of MIDI (Musical Instrument Digital Interface) files. MIDI files make it possible to exchange information such as: musical notes, program changes, expression control and channel information between musical instruments, sequencers, computers, lighting controllers and mixers. MIDI files generally consist of serially listed channel and system messages which include at least program status messages and matching note on and note off messages. The method and apparatus of the present invention may be utilized to ensure the integrity of a source file, a copied or lifted section or a target file by automatically inserting matching note on or note off messages into a file or file section to correct inconsistencies created by such editing.

Abstract: A system and method for translating MIDI files is used with a sequencer and synthesizer. When a MIDI file is imported into a system, the file is scanned and voice assignment information extracted. This information is stored in a converted file. If desired, the extracted information can be stored using MIDI system exclusives. This allows either any original program change information, or the extracted information, to be used during a performance of the converted MIDI file.

Abstract: A word processing system is provided having a bidirectional printer with formatting capability. The system includes a word processor having means for outputting a stream of sequential data readable in only one direction. The data comprises blocks of character data representative of the characters to be printed interspersed with blocks of control data representative of the format in which the characters are to be printed; each block of control data has an immediately preceding control block identifier. The bidirectional printer includes means for receiving the stream of sequential data, means for scanning the stream of data and means for inserting a control block identifier at the end of each control block which identifier corresponds to the identifier preceding the control block, whereby the stream of sequential data is made readable in both the forward and reverse directions within the printer.

Abstract: In a high speed trail printer an improved electronic tab rack is provided. A method and apparatus are disclosed for decreasing the time required to determine the location of the next tab involving accessing a condensed tab rack. The condensed tab rack is set up when the tabs are entered and contains for each byte of the basic tab rack one bit indicating whether or not the associated tab rack byte specifies at least one tab stop position.