Patents by Inventor Daniel J. Myers
Daniel J. Myers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090301363Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.Type: ApplicationFiled: June 16, 2009Publication date: December 10, 2009Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Ramesh Damani, Ron L. Hale, Daniel J. Myers, Reynaldo J. Quintana, Dennis W. Solas, Soonho Song, Pravin Soni, Curtis Tom, Kirshnamohan Sharma
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Publication number: 20090235926Abstract: Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.Type: ApplicationFiled: May 29, 2009Publication date: September 24, 2009Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Steven D. Cross, Matthieu Herbette, Andrew J.G. Kelly, Daniel J. Myers, William W. Shen, Ryan D. Timmons, Curtis Tom, Justin M. Virgili, Martin J. Wensley
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Publication number: 20090229600Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.Type: ApplicationFiled: May 22, 2009Publication date: September 17, 2009Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Patent number: 7585493Abstract: An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0.05 and 20 ?m. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.Type: GrantFiled: August 4, 2003Date of Patent: September 8, 2009Assignee: Alexza Pharmaceuticals, Inc.Inventors: Ron L. Hale, Amy Lu, Daniel J. Myers, Joshua D. Rabinowitz, Martin J. Wensley
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Patent number: 7540286Abstract: Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.Type: GrantFiled: June 3, 2004Date of Patent: June 2, 2009Assignee: Alexza Pharmaceuticals, Inc.Inventors: Steven D. Cross, Mathieu Herbette, Andrew J. G. Kelly, Daniel J. Myers, William W. Shen, Ryan D. Timmons, Curtis Tom, Justin M. Virgili, Martin J. Wensley
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Patent number: 7537009Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 ? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.Type: GrantFiled: May 13, 2002Date of Patent: May 26, 2009Assignee: Alexza Pharmaceuticals, Inc.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Publication number: 20080311176Abstract: The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 ?m, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.Type: ApplicationFiled: May 8, 2008Publication date: December 18, 2008Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Amy T. Lu, Daniel J. Myers, Joshua D. Rabinowitz, Martin J. Wensley, Jeffrey A. McKinney, Alejandro C. Zaffaroni
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Publication number: 20080216828Abstract: Drug supply units are disclosed which comprise substrates having a plurality of holes formed therein.Type: ApplicationFiled: March 10, 2008Publication date: September 11, 2008Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Martin J. Wensley, Marc Glazer, James Bresson, Ryan Timmons, Daniel J. Myers
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Patent number: 7090830Abstract: The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1–3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 ?m, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.Type: GrantFiled: November 20, 2003Date of Patent: August 15, 2006Assignee: Alexza Pharmaceuticals, Inc.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Amy T. Lu, Daniel J. Myers, Joshua D. Rabinowitz, Martin J. Wensley
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Publication number: 20040099266Abstract: A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0.02 and 0.1 MMAD or between 1 and 3.5 &mgr;m. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.Type: ApplicationFiled: May 20, 2003Publication date: May 27, 2004Inventors: Stephen Cross, Craig C. Hodges, Ron L. Hale, Peter M. Lloyd, Daniel J. Myers, Reynaldo J. Quintana, Joshua D. Rabinowitz, Curtis Tom, Martin J. Wensley
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Publication number: 20040099269Abstract: The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 &mgr;m, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.Type: ApplicationFiled: November 20, 2003Publication date: May 27, 2004Applicant: Alexza Molecular Delivery CorporationInventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Amy T. Lu, Daniel J. Myers, Joshua D. Rabinowitz, Martin J. Wensley
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Publication number: 20030015197Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10&mgr; thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.Type: ApplicationFiled: May 13, 2002Publication date: January 23, 2003Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Patent number: 4346829Abstract: A roll dispenser carbon for dispensing sheet material, e.g., food wrap type sheet material. A unique cutting edge structure on the carton permits tearing off a length of the sheet material after that length has been withdrawn from the roll inside the carton. In the case of certain type sheet materials, the cutting edge structure retains the remaining free edge of the sheet material on the cutting edge after the desired sheet length has been torn from the roll. The cutting edge structure is comprised of a series of punched buds, each bud having at least two petals, that are formed in a metal sheet by punching that sheet with a piercing punch.Type: GrantFiled: September 2, 1980Date of Patent: August 31, 1982Assignee: The Nivison-Weiskopf Co.Inventor: Daniel J. Myers
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Patent number: 4234116Abstract: An adjustable carrier in which an elongated band is threaded to a belt-mounted support to provide an adjustable inner span which cooperates with the support to hold an article therebetween and in which the ends of the band are detachably coupled to permit adjustment of the intermediate span and to lock it in tightened condition.Type: GrantFiled: April 13, 1979Date of Patent: November 18, 1980Inventor: Daniel J. Myers