Abstract: The present disclosure is directed to self-synchronizing devices that can connect and self-synchronizes voltage, frequency and phase of two or more power sources. The disclosed embodiments enable a modular power system to serve as the primary or secondary source of power for applications requiring loads from a few kilowatts (kW) to the scale of megawatts (MW). The modular system is generalized to use either a single or multiple power generation sources at once, with the ability to connect and self-synchronize voltage, frequency, and phase of a variety of different types of power sources. Power control systems designed to function with self-synchronizing technology enable a modular power system to satisfy a wide variety of needs, simplifying the existing method of achieving synchronization and enabling new features of resiliency and expandability. The self-synchronization can be implemented into a wide variety of electronics including but not limited to inverters and generator controllers.

Abstract: The present disclosure is directed to self-synchronizing devices that can connect and self-synchronizes voltage, frequency and phase of two or more power sources. The disclosed embodiments enable a modular power system to serve as the primary or secondary source of power for applications requiring loads from a few kilowatts (KW) to the scale of megawatts (MW). The modular system is generalized to use either a single or multiple power generation sources at once, with the ability to connect and self-synchronize voltage, frequency, and phase of a variety of different types of power sources. Power control systems designed to function with self-synchronizing technology enable a modular power system to satisfy a wide variety of needs, simplifying the existing method of achieving synchronization and enabling new features of resiliency and expandability. The self-synchronization can be implemented into a wide variety of electronics including but not limited to inverters and generator controllers.

Abstract: A method includes: receiving system data corresponding to an engine system. The system data includes a plurality of remaining useful life (RUL) values with each RUL value associated with a component of the engine system. The method further includes: comparing a first RUL value to a service interval threshold; generating a near-term service recommendation including a first list of components that correspond to each RUL value that are less than or equal to the service interval threshold; generating an extended term service recommendation including a second list of components and a downtime prediction; generating a coordinated service recommendation by dynamically populating one or more fields of the coordinated service recommendation based on the near-term service recommendation and the extended term service recommendation; and providing the combined service recommendation to a user device.

Abstract: Articles with covalently attached thiocarbonylthio-containing groups are provided. More specifically, the articles include a solid polymeric substrate with a plurality of thiocarbonylthio-containing groups covalently attached directly to a carbon atom in a polymeric backbone of the solid polymeric substrate. Methods of making the articles with covalently attached thiocarbonylthio-containing are provided. Additionally, methods of using these articles to generate further articles with covalently attached polymeric chains are provided.

Abstract: Systems and methods for determining a remaining useful life (RUL) of a component of an engine system are provided. A method includes: receiving component data comprising sensor data corresponding to a component and engine data; pre-processing the component data by removing a first set of sensor data values that correspond to a first set of engine data values of the engine data; aggregating the pre-processed component data by grouping a second set of sensor values of the sensor data; determining a RUL for the component based on a RUL model that correlates at least a portion of the aggregated data to RUL values; adjusting the RUL based on at least one of detecting a service event or determining that one or more sensor data values of the sensor data are outside a predetermined range of values; and providing the RUL to a user device.

Abstract: Viral filtration media, an article comprising the viral filtration media, and a method of filtering a virus-containing sample using the viral filtration media, wherein the viral filtration media comprises: a porous substrate comprising a surface having a polymer grafted thereto, wherein the grafted polymer comprises interpolymerized monomers comprising: a (meth)acrylic acid monomer: and, optionally, a poly (alkylene oxide) monomer.

Abstract: A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided.

Abstract: The spinal cord stimulation device of this invention is configured for implantation into a patient so as to traverse the dura mater that surrounds the spinal cord. Placing the device in this location provides direct contact between the electrode and the cerebrospinal fluid (CSF), in close proximity to the spinal cord. The device has an intradural portion and an extradural portion that compresses and seals the dural membrane between them, securing the device in position and preventing leakage of CSF. The position of the device may be stabilized in relation to the spinal cord by way of a laminoplasty plate, bridging between the device and a vertebra. The device is electronically powered by an implanted pulse generator that produces a spectrum of signals to interrupt or otherwise attenuate transmission of pain mediating neural signals through the spinal cord.

Abstract: A charged depth filter for removing cells and/or cellular debris from a biopharma feedstock having a first functionalized nonwoven layer having a first calculated pore size and a first dynamic charge capacity; a second functionalized nonwoven layer having a second calculated pore size and a second dynamic charge capacity positioned after the first functionalized nonwoven layer in the direction of the biopharma feedstock flow, and wherein the first calculated pore size is greater than the second calculated pore size, and the first dynamic charge capacity is less than the second dynamic charge capacity.

Abstract: A method, comprising: with a cutting graph corresponding to a two-dimensional (2-D) representation of a polyhedral mesh that is representative of the 3-D target object, forming i sheets in conformity with the cutting graph, i being from 1 to n, an i-th 2-D sheet having an i-th set of cuts formed therein, an (i+1)-th 2-D sheet having a (i+1)-th set of cuts formed therein, the (i+1)-th set of cuts optionally differing from the i-th set of cuts. A 3-D composite object having a surface, the 3-D composite object comprising: i stacked and consolidated sheets, i being from 1 to n, an i-th sheet having an i-th set of cuts formed therein, an (i+1)-th sheet having a (i+1)-th set of cuts formed therein, the (i+1)-th set of cuts optionally differing from the i-th set of cuts.

Abstract: Described herein is a method of purifying a target molecule from an aqueous biological composition, the method comprising: (a) contacting a cationic polymer and the aqueous biological composition to form a mixture comprising a bio-polymer complex and the target molecule in a liquid, wherein the bio-polymer complex has an average particle diameter of at least 45 micrometers, (b) adding the mixture to a filtering volume of a vessel, wherein the vessel comprises loosely packed staple fibers; (c) allowing the mixture to separate through the loosely packed staple fiber; and (d) collecting a filtrate comprising the target molecule.

Abstract: Described herein is a method of purifying a target molecule from an aqueous biological composition, the method comprising: (a) contacting a cationic polymer and the aqueous biological composition to form a mixture, the mixture comprising a bio-polymer complex and the target non-binding molecule in a liquid, wherein the bio-polymer complex has an average particle diameter of at least 50 micrometers; (b) providing a filtering unit comprising (i) a housing having an inlet and an outlet, (ii) a porous, continuous filter medium which is fluidly connected to the inlet and the outlet, and (iii) a collection region upstream from the porous, continuous filter medium; (c) adding the mixture to the inlet; and (d) allowing the mixture to separate in the filtering unit, whereby the bio-polymer complex collects in the collection region and the target non-binding molecule passes through the filter medium, and wherein the majority of flow of the liquid through the porous, continuous filter medium is not substantially paralle

Abstract: Systems, apparatuses, and methods of controlling an ignitor are disclosed. A method includes: receiving, by a controller, fuel quality data regarding a fuel for a spark-ignition engine; determining, by the controller, a fuel quality metric based on the fuel quality data; and controlling, by the controller, an ignition energy characteristic of an ignitor in response to the fuel quality metric.

Abstract: Spark plugs are disclosed that include electrode arrangements to improve the charge flow into and out of the annular volume around the insulator nose and a pre-chamber volume of a pre-chamber device, thus directing a purge of exhaust gases trapped in the annular volume to a space formed by the exterior of the spark plug body and the interior of the pre-chamber device.

Abstract: A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided.

Abstract: Systems, apparatuses, and methods of controlling an ignitor are disclosed. A method includes: receiving, by a controller, fuel quality data regarding a fuel for a spark-ignition engine; determining, by the controller, a fuel quality metric based on the fuel quality data; and controlling, by the controller, an ignition energy characteristic of an ignitor in response to the fuel quality metric.

Abstract: Systems and methods for treating a cognitive disease or disorder are provided. A treatment method comprises: selecting a target volume of brain tissue to be stimulated; identifying at least one avoidance volume of brain tissue; selecting a first stimulation lead comprising at least one stimulation element; identifying at least one proposed trajectory for placement of the first stimulation lead based on the target volume and the at least one avoidance volume; placing the first stimulation lead along a placement trajectory selected from the at least one proposed trajectory; attaching the first stimulation lead to a stimulator; and stimulating the target volume with the first stimulation lead at least one stimulation element to treat at least one of a cognitive disease or a cognitive disorder. Systems include a stimulator with one or more stimulation leads and an image analyzer for identifying a proposed trajectory for placing the stimulation leads.

Abstract: A combustion pre-chamber assembly includes pre-chamber device body defining an annular plenum that is in fluid communication with the at least one bore that extends through the spark plug shell. The annular plenum is also in communication with at least one purging passage that extends from the annular plenum to an end surface of the pre-chamber device body. Residual exhaust gases in the annular volume of the spark plug are purged by fresh charge flow from the main combustion chamber as the piston approaches top dead center. The fresh charge flow that is provided to the annular plenum through the at least one purging passage and into the annular volume of the spark plug through the at least one bore through the spark plug shell.

Abstract: Described herein are aptamers capable of binding to human complement component 3 (C3) protein; compositions comprising a C3 binding aptamer with a C3-Protein; and methods of making and using the same.

Abstract: A method of controlling an ignitor for a spark-ignition engine includes receiving, by a controller, at least one of fuel quality data regarding a fuel for the spark-ignition engine or a characteristic regarding the ignitor for the spark-ignition engine. The method additionally includes controlling, by the controller, an ignition energy characteristic of the ignitor in response to the at least one of the fuel quality data regarding the fuel or the characteristic regarding the ignitor for the spark-ignition engine.