Abstract: The present invention provides methods and kits for assessing whether a subject is afflicted with an FR?-expressing cancer, methods and kits for predicting the progression of ovarian cancer in a subject afflicted with an FR?-expressing cancer, methods and kits for assessing the level of risk that a subject will develop an FR?-expressing cancer, and methods of stratifying a subject with an FR?-expressing cancer into cancer therapy groups. The methods involve determining the level of folate receptor alpha (FR?) which is not bound to a cell in a sample derived from the subject and comparing this level with the level of FR? in a control sample.

Abstract: The invention relates to methods and kits for assessing occurrence in woman urine of peptides having amino acid sequences related to those of mesothelin, megakaryocyte potentiating factor, and other peptides that have been associated with occurrence in the serum of ovarian cancer patients. The methods and kits can be used to diagnose ovarian cancer in a woman, to predict development of ovarian cancer in an otherwise asymptomatic woman, or to assess the efficacy of an ovarian cancer therapeutic method.

Abstract: An improved surface plasmon resonance detector, capable of recovering a desired eluted ligate, permits the isolation and characterization of novel ligates and ligands.

Abstract: An improved surface plasmon resonance detector, capable of recovering a desired eluted ligate allows for the collection and subsequent analysis of ligate solutions following interaction of the ligate with an immobilized ligand on a surface of a sensor chip of the surface plasmon resonance detector, permits the isolation and characterization of novel ligates and ligands.

Abstract: A biological composition comprises a solid phase support matrix or marker molecule bound to protein, typically a glycoprotein such as an immunoglobulin through a linking group, spacer arm, and hydrazone group. The linking group is conveniently an ether linkage, while the spacer arm is a linear chain including six atoms, where at least one of the atoms is a tertiary amine which is protonated at a pH below about 8. The hydrazone is formed by reacting the solid phase or marker molecule having the linking arm and the spacer arm including a terminal hydrazide group with a glycoprotein oxidized to include a terminal aldehyde group. Immunological reagents prepared by linking an immunoglobulin (IgG) through a carbohydrate on the Fc or hinge regions have been found to provide very high binding capacity approaching the theoretical bivalent limit of two moles of bound antigen for every mole of bound immunoglobulin.