Abstract: The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor, more particularly, use in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. More particularly, the compounds of the present invention are useful in the treatment of metabolic disorders.

Abstract: The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, use in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. More particularly, the compounds of the present invention are useful in the treatment of metabolic disorders.

Abstract: The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

Abstract: The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, use in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. More particularly, the compounds of the present invention are useful in the treatment of metabolic disorders.

Abstract: The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

Abstract: The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

Abstract: Disclosed are compounds, compositions and methods for treating Type II diabetes and other disorders affected by activity of the enzyme PDE10a. Such compounds are represented by Formula (I) below, wherein R1, R2, L and Q are defined herein.

Abstract: Disclosed are compounds, compositions and methods for treating Type II diabetes. Such compounds are represented by Formula (I) as follows: wherein R1, R2, L, and Q are defined herein.

Abstract: A virtual thermostat system and method are provided. The method accepts commands via a virtual thermostat interface for establishing temperature set points for a plurality of zones. Energy consumption information is also accepted from a plurality of energy consumption units. Each unit consumes energy at an associated peak power to supply a controlled temperature medium to a corresponding zone. The method also accepts temperature measurements for each zone. Then, consumption commands are sent to each energy consumption unit in response to associated zone temperature set points, while insuring that a combined peak power of the energy consumption units is less than a maximum peak power threshold. In one aspect, the virtual thermostat accepts temperature measurements from a plurality of physical thermostats, each associated with an energy consumption unit. Then, consumption commands are relayed to the energy consumption units via associated physical thermostats.

Abstract: A system and method are provided for calculating power using a voltage waveform shape measurement from a contactless sensor. An electrically conductive medium carries alternating current (AC) electrical current, associated with an AC voltage, from a source node to a destination node. AC current is measured through the electrically conductive medium. Using a contactless sensor, an AC voltage waveform shape is measured. The power usage at the destination node is calculated in response to the AC current measurement, the measurement of the AC voltage waveform shape, and an AC voltage potential. For simplicity, the AC current and AC voltage waveform shape may both be measured at a first node located between the source node and the destination node. The AC voltage potential used in the power usage calculation may be an estimate, an actual measurement, or a value supplied by an external source (e.g., the power utility).

Abstract: The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

Abstract: The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

Abstract: Disclosed are compounds, compositions and methods for treating Type II diabetes. Such compounds are represented by Formula (I) as follows: wherein R1, R2, L, and Q are defined herein.

Abstract: Disclosed are compounds, compositions and methods for treating Type II diabetes. Such compounds are represented by Formula (I) as follows: wherein R1, R2, L, and Q are defined herein.

Abstract: A multi-dimensional energy control system is provided with an energy management software application that organizes the consumption of energy by a device as an n-dimensional energy space, where n is an integer greater than 2, and each axis in the energy space represents an energy consumption characteristic. The energy management application generates instructions for a device in response to calculating a compromise operating point in the energy space. A user interface (UI) connected to the energy management application has a display to receive a graphical representation of the energy space and compromise operating point, and an input to receive user commands for moving the represented compromise operating point in the represented energy space. The energy management application calculates the compromise operating point in the energy space to match the displayed compromise operating point.

Abstract: A system and method are provided for calculating power using a voltage waveform shape measurement from a contactless sensor. An electrically conductive medium carries alternating current (AC) electrical current, associated with an AC voltage, from a source node to a destination node. AC current is measured through the electrically conductive medium. Using a contactless sensor, an AC voltage waveform shape is measured. The power usage at the destination node is calculated in response to the AC current measurement, the measurement of the AC voltage waveform shape, and an AC voltage potential. For simplicity, the AC current and AC voltage waveform shape may both be measured at a first node located between the source node and the destination node. The AC voltage potential used in the power usage calculation may be an estimate, an actual measurement, or a value supplied by an external source (e.g., the power utility).

Abstract: The present invention relates generally to the field of diagnostic and detection assays. More particularly, the present invention provides methods and reagents including biochips for detecting the presence of, or distinguishing between, one or more analytes in a sample.

Abstract: Systems and devices for, and methods of, energy management via prompted response options based on detected anomalous conditions.

Abstract: Systems and devices for, and methods of, adaptive local energy storage capacity by changing operating set points of regulated energy load devices based on the presence, or absence, of an excess of available, generated energy.

Abstract: A virtual thermostat system and method are provided. The method accepts commands via a virtual thermostat interface for establishing temperature set points for a plurality of zones. Energy consumption information is also accepted from a plurality of energy consumption units. Each unit consumes energy at an associated peak power to supply a controlled temperature medium to a corresponding zone. The method also accepts temperature measurements for each zone. Then, consumption commands are sent to each energy consumption unit in response to associated zone temperature set points, while insuring that a combined peak power of the energy consumption units is less than a maximum peak power threshold. In one aspect, the virtual thermostat accepts temperature measurements from a plurality of physical thermostats, each associated with an energy consumption unit. Then, consumption commands are relayed to the energy consumption units via associated physical thermostats.