Abstract: The present invention relates generally to nitric oxide releasing pharmaceutical compounds. More particularly, the present invention relates to pharmaceutical compositions that release nitric oxide under physiological conditions. In one embodiment, the present invention relates to new chemical compounds—diazeniumdiolates nitric oxide donors—that are based on ethambutol possessing physiological and biomedical activity.

Abstract: The present invention relates to nanofibrous coatings on medical devices such a surgical mesh or stent, wherein the coating is mechanically attached to the device. The principal mechanism for attaching the coating is through causing the fibers to permeate and entangle with the substrate.

Abstract: Certain embodiments of the present invention provide a control panel mount having one or more strain relief features. The mount has a base and a tether. The tether has a first end and a second end. The first end of the tether is rotatably connected to the base. The second end of the tether is adapted to receive a cable tie.

Abstract: Systems and methods for creating and managing user-customized financial products are operable to create a plurality of user-customized financial products, each a discrete financial instrument comprising a baseline financial product comprised of a combination of one or more underlying product components, where each underlying product components comprises one or more user-customized component parameters. Once created, the plurality of user-customized financial products are disaggregated into their respective underlying product components and associated component values. Next, all component values associated with each of the underlying product components are aggregated, and at least one back-to-back hedging transaction for the aggregated component value of at least one of the underlying product components is executed.

Abstract: An alarm unit for signaling impending overflow of a urine or ostomy (waste) bag includes an external magnet held at the end of an arm. An internal ferrous armature attracts the magnet which provides flux holding a switch element open when the magnet provides at least a predetermined flux to the switch. A clamp allows the user to fasten the unit to an edge of the waste bag with the bag walls between the magnet and the armature. When the bag contents reach the magnet, fluid force of the bag contents separates the magnet and the armature, causing the switch element to close and conduct power from a power supply to a signal element. The arm may be flexible. The switch element preferably comprises a reed switch controlling an electronic power switch.

Abstract: Systems and methods for creating and managing user-customized financial products are operable to create a plurality of user-customized financial products, each a discrete financial instrument comprising a baseline financial product comprised of a combination of one or more underlying product components, where each underlying product components comprises one or more user-customized component parameters. Once created, the plurality of user-customized financial products are disaggregated into their respective underlying product components and associated component values. Next, all component values associated with each of the underlying product components are aggregated, and at least one back-to-back hedging transaction for the aggregated component value of at least one of the underlying product components is executed.

Abstract: A method of mechanically treating alloy metal surgical needles to improve bending strength is disclosed. The needles are curved and reverse-curved in this method to improve bending strength.

Abstract: The present invention relates to methods for removal of dead tissue from wounds or skin using topical nitric oxide donor devices and/or compositions. In one embodiment, the present invention relates to a transdermal patch device that is designed to deliver nitric oxide. In another embodiment, the present invention relates to one or more devices and/or compositions that are designed to deliver nitric oxide and optionally one or more other compounds, where such devices/compositions include, without limitation, bandages, layered bandages, adhesive bandages, transdermal patches, creams, ointments, or a any combination of two or more thereof.

Abstract: In one embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; and an elastomeric component, and wherein the non-woven fiber assembly further comprises an adhesive component. In still another embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; an elastomeric component; and an adhesive component, wherein the hydrophilic component, the elastomeric component and the adhesive component are all contained within each fiber. Also disclosed is a method of making the afore-mentioned non-woven fiber assemblies. Additionally, a medical dressing made from the non-woven fiber assemblies of the present invention is disclosed.

Abstract: A medical patch system has a first medical patch including an outer locating ring secureable to a surface and an inner patch, separable from the outer locating ring, disposed within the outer locating ring. The medical patch system includes a second medical patch adapted for insertion into the central area bounded by the outer locating ring after the inner patch is separated from the outer locating ring. The second medical patch includes a second outer locating ring secureable to the surface, and a second inner patch section, separable from the second outer locating ring, disposed within a second central area bounded by the second outer locating ring. The first and second outer locating rings have adhesive layers for securing the outer locating rings to a surface. The adhesive layers on the respective outer locating rings have different sizes, shapes or patterns to minimize skin irritation.

Abstract: In one embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; and an elastomeric component, and wherein the non-woven fiber assembly further comprises an adhesive component. In still another embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; an elastomeric component; and an adhesive component, wherein the hydrophilic component, the elastomeric component and the adhesive component are all contained within each fiber. Also disclosed is a method of making the afore-mentioned non-woven fiber assemblies. Additionally, a medical dressing made from the non-woven fiber assemblies of the present invention is disclosed.

Abstract: Certain embodiments of the present invention provide a control panel mount having one or more strain relief features. The mount has a base and a tether. The tether has a first end and a second end. The first end of the tether is rotatably connected to the base. The second end of the tether is adapted to receive a cable tie.

Abstract: A support for a body of a stringed instrument includes a brace structure having a plurality of legs radially disposed about a central body. The brace structure has a substantially flat first surface. A portion of the plurality of legs conforms to a soundhole opening which is integrated into the body of the stringed instrument. A brace for a body of a guitar includes a unitary structure adapted to mount to a soundboard of the guitar. The unitary structure has a plurality of arms radially disposed about a central body. A method of assembling a guitar includes mounting a brace structure to a soundboard of the guitar. Again, the brace structure has a plurality of legs radially disposed about a central body.

Abstract: A pelvic floor implant including a central body portion having an anterior edge having a centrally located recess therein, a posterior edge having a centrally located tab, and first and second lateral side edges. First and second strap-like extension portions extend outwardly to first and second distal ends from first and second end regions of the posterior edge of the central body portion. The first and second strap-like extension portions extending outwardly at an angle so as to form a substantially “Y” shaped implant in combination with the central body portion. First and second pockets are located at the first and second distal ends of the first and second strap-like extensions respectively, each having a closed end substantially adjacent to the distal end of the strap-like extension, and having an open end proximal thereto and opening toward the central body portion.

Abstract: A nanofiber-reinforced composition suited to applying to a wound site in a human body includes a carrier liquid and nanofibers dispersed therein. The viscosity of the composition is such that it is able to be applied through a tube yet adhere proximate the wound site to provide a barrier layer which assists in healing of the wound by spacing it from neighboring organs.

Abstract: A medical implant and method for its implantation. One use is for treatment of stress urinary incontinence and includes an implantable, elongated tape having a multiplicity of openings formed through the thickness thereof, the tape having a first end region and a second end region longitudinally opposite the first end region, and first and second bio-absorbable fixation elements attached to the first and second end regions of the tape respectively. Each bio-absorbable fixation element has a tissue adherence property greater than that of the tape and has a substantially rectangular, planar configuration without physical projections extending outwardly therefrom.

Abstract: An indicator device for determining the efficacy of an antimicrobial treatment process. The indicator device includes an active agent encapsulated in an encapsulation component. The encapsulation components preferably takes the form of an electrospun nanofiber including a polymer.

Abstract: A support for a body of a stringed instrument includes a brace structure having a plurality of legs radially disposed about a central body. The brace structure has a substantially flat first surface. A portion of the plurality of legs conforms to a soundhole opening which is integrated into the body of the stringed instrument. A brace for a body of a guitar includes a unitary structure adapted to mount to a soundboard of the guitar. The unitary structure has a plurality of arms radially disposed about a central body. A method of assembling a guitar includes mounting a brace structure to a soundboard of the guitar. Again, the brace structure has a plurality of legs radially disposed about a central body.

Abstract: A support for a body of a stringed instrument includes a brace structure having a plurality of legs radially disposed about a central body. The brace structure has a substantially flat first surface. A portion of the plurality of legs conforms to a soundhole opening which is integrated into the body of the stringed instrument. A brace for a body of a guitar includes a unitary structure adapted to mount to a soundboard of the guitar. The unitary structure has a plurality of arms radially disposed about a central body. A method of assembling a guitar includes mounting a brace structure to a soundboard of the guitar. Again, the brace structure has a plurality of legs radially disposed about a central body.

Abstract: A headblock and fingerboard support assembly for a stringed instrument includes a fingerboard support assembly for mounting to a neck and fingerboard of the stringed instrument. The fingerboard support assembly further includes a plate having an integrated rail structure. A headblock has an integrated channel for receiving the integrated rail structure. The headblock is adapted to secure to the fingerboard support assembly. A method of assembling a stringed instrument includes mounting a plate structure to a neck and fingerboard of the stringed instrument, where the plate includes an integrated rail, and mounting a headblock to an interior surface of a body of the stringed instrument, where the headblock has an integrated channel structure for receiving the integrated rail of the plate structure.