Patents by Inventor Daniel J. Solis
Daniel J. Solis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200398277Abstract: The present invention describes a device(s) and assay(s) for the isolation and analysis of individual components from a sample. The invention provides a means of both isolating a multitude of individual components into an organized array and the subsequent analysis of such components by various detection and analysis methodologies. The invention provides a significant advancement in both the number of individual components that can be individually analyzed as well as enabling the quality and number of analytical methodologies that can be applied to them.Type: ApplicationFiled: January 17, 2017Publication date: December 24, 2020Inventors: Daniel J. Solis, Edward H. Cho
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Publication number: 20200009561Abstract: The present invention describes a device(s) and assay(s) for the isolation and analysis of individual components from a sample. The invention provides a means of both isolating a multitude of individual components into an organized array and the subsequent analysis of such components by various detection and analysis methodologies. The invention provides a significant advancement in both the number of individual components that can be individually analyzed as well as enabling the quality and number of analytical methodologies that can be applied to them.Type: ApplicationFiled: September 16, 2019Publication date: January 9, 2020Inventors: Daniel J. Solis, Edward H. Cho
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Patent number: 10247700Abstract: A technique relates to manufacturing a nanogap. An oxide layer is disposed on top of a substrate. A release layer is disposed in a pattern on top of the oxide layer. A patterned trench is etched into the oxide layer using the pattern of the release layer. A metal layer is disposed on the release layer and in the patterned trench. A polish removes the release layer, thereby removing both the release layer and a portion of the metal layer having been disposed on top of the release layer, such that the metal layer remaining includes a first metal part and a second metal part connected by a metal nanowire. The metal layer remaining is coplanar with the oxide layer. A nanochannel is formed in the oxide layer in a region of the metal nanowire. The nanogap is formed in the metal nanowire separating the first and second metal parts.Type: GrantFiled: October 30, 2015Date of Patent: April 2, 2019Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, BIONANO GENOMICS, INC.Inventors: Huan Hu, Michael F. Lofaro, Joshua T. Smith, Benjamin H. Wunsch, Daniel J. Solis
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Publication number: 20180200715Abstract: The present invention describes a device(s) and assay(s) for the isolation and analysis of individual components from a sample. The invention provides a means of both isolating a multitude of individual components into an organized array and the subsequent analysis of such components by various detection and analysis methodologies. The invention provides a significant advancement in both the number of individual components that can be individually analyzed as well as enabling the quality and number of analytical methodologies that can be applied to them.Type: ApplicationFiled: January 17, 2017Publication date: July 19, 2018Inventors: Daniel J. Solis, Edward H. Cho
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Patent number: 9879360Abstract: Disclosed herein is a microfluidic device comprising a chip; a flow channel being disposed in the chip; the flow channel being in communication with an entry port and an exit port; the flow channel being operative to permit the flow of a library from the entry port to the exit port; a substrate; the substrate being disposed upon the chip; the substrate being operative to act as an upper wall for the flow channels; and a plurality of receptors; the plurality of receptors being disposed on the substrate; the plurality of receptors being operative to interact with an element from the library.Type: GrantFiled: June 20, 2008Date of Patent: January 30, 2018Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Emmanuel Delamarche, Robert Lovchik, Daniel J. Solis
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Patent number: 9804122Abstract: A technique relates to manufacturing a nanogap. An oxide layer is disposed on top of a substrate. A release layer is disposed in a pattern on top of the oxide layer. A patterned trench is etched into the oxide layer using the pattern of the release layer. A metal layer is disposed on the release layer and in the patterned trench. A polish removes the release layer, thereby removing both the release layer and a portion of the metal layer having been disposed on top of the release layer, such that the metal layer remaining includes a first metal part and a second metal part connected by a metal nanowire. The metal layer remaining is coplanar with the oxide layer. A nanochannel is formed in the oxide layer in a region of the metal nanowire. The nanogap is formed in the metal nanowire separating the first and second metal parts.Type: GrantFiled: November 25, 2015Date of Patent: October 31, 2017Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, BIONANO GENOMICS, INC.Inventors: Huan Hu, Michael F. Lofaro, Joshua T. Smith, Daniel J. Solis, Benjamin H. Wunsch
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Publication number: 20170120246Abstract: A technique relates to manufacturing a nanogap. An oxide layer is disposed on top of a substrate. A release layer is disposed in a pattern on top of the oxide layer. A patterned trench is etched into the oxide layer using the pattern of the release layer. A metal layer is disposed on the release layer and in the patterned trench. A polish removes the release layer, thereby removing both the release layer and a portion of the metal layer having been disposed on top of the release layer, such that the metal layer remaining includes a first metal part and a second metal part connected by a metal nanowire. The metal layer remaining is coplanar with the oxide layer. A nanochannel is formed in the oxide layer in a region of the metal nanowire. The nanogap is formed in the metal nanowire separating the first and second metal parts.Type: ApplicationFiled: November 25, 2015Publication date: May 4, 2017Inventors: Huan Hu, Michael F. Lofaro, Joshua T. Smith, Benjamin H. Wunsch, Daniel J. Solis
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Publication number: 20170122903Abstract: A technique relates to manufacturing a nanogap. An oxide layer is disposed on top of a substrate. A release layer is disposed in a pattern on top of the oxide layer. A patterned trench is etched into the oxide layer using the pattern of the release layer. A metal layer is disposed on the release layer and in the patterned trench. A polish removes the release layer, thereby removing both the release layer and a portion of the metal layer having been disposed on top of the release layer, such that the metal layer remaining includes a first metal part and a second metal part connected by a metal nanowire. The metal layer remaining is coplanar with the oxide layer. A nanochannel is formed in the oxide layer in a region of the metal nanowire. The nanogap is formed in the metal nanowire separating the first and second metal parts.Type: ApplicationFiled: October 30, 2015Publication date: May 4, 2017Inventors: Huan Hu, Michael F. Lofaro, Joshua T. Smith, Benjamin H. Wunsch, Daniel J. Solis
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Patent number: 9594082Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.Type: GrantFiled: March 26, 2015Date of Patent: March 14, 2017Assignee: International Business Machines CorporationInventors: Emmanuel Delamarche, Daniel J. Solis
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Publication number: 20150198596Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.Type: ApplicationFiled: March 26, 2015Publication date: July 16, 2015Inventors: Emmanuel Delamarche, Daniel J. Solis
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Patent number: 9012136Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.Type: GrantFiled: October 30, 2008Date of Patent: April 21, 2015Assignee: International Business Machines CorporationInventors: Emmanuel Delamarche, Daniel J. Solis
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Patent number: 9005887Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.Type: GrantFiled: April 30, 2012Date of Patent: April 14, 2015Assignee: International Business Machines CorporationInventors: Emmanuel Delamarche, Daniel J. Solis
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Patent number: 8969252Abstract: The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material.Type: GrantFiled: April 7, 2011Date of Patent: March 3, 2015Assignee: Board of Regents, University of Texas SystemInventors: Angela M. Belcher, Brian D. Reiss, Chuanbin Mao, Daniel J. Solis
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Patent number: 8846190Abstract: Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire.Type: GrantFiled: August 27, 2013Date of Patent: September 30, 2014Assignees: The Board of Regents, The University of Texas System, Massachusetts Institute of TechnologyInventors: Angela M. Belcher, Chuanbin Mao, Daniel J. Solis
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Publication number: 20140212664Abstract: Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire.Type: ApplicationFiled: August 27, 2013Publication date: July 31, 2014Applicants: Massachusetts Institute of Technology, Board of Regents, The University of Texas SystemInventors: Angela M. BELCHER, Chuanbin MAO, Daniel J. SOLIS
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Patent number: 8680023Abstract: Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate.Type: GrantFiled: August 21, 2008Date of Patent: March 25, 2014Assignee: International Business Machines CorporationInventors: Sean R. Coyer, Emmanuel Delamarche, Daniel J. Solis
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Patent number: 8680024Abstract: Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate.Type: GrantFiled: March 26, 2012Date of Patent: March 25, 2014Assignee: International Business Machines CorporationInventors: Sean R. Coyer, Emmanuel Delamarche, Daniel J. Solis
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Patent number: 8523044Abstract: Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire.Type: GrantFiled: June 18, 2012Date of Patent: September 3, 2013Assignees: Board of Regents, The University of Texas System, Massachusetts Institute of TechnologyInventors: Angela M. Belcher, Chuanbin Mao, Daniel J. Solis
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Publication number: 20120283133Abstract: A microfluidic device includes a chip; a flow channel being disposed in the chip; the flow channel being in communication with an entry port and an exit port; the flow channel being operative to permit the flow of a library from the entry port to the exit port; a substrate; the substrate being disposed upon the chip; the substrate being operative to act as an upper wall for the flow channels; and a plurality of receptors; the plurality of receptors being disposed on the substrate; the plurality of receptors being operative to interact with an element from the library.Type: ApplicationFiled: July 18, 2012Publication date: November 8, 2012Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Emmanuel Delamarche, Robert Lovchik, Daniel J. Solis
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Publication number: 20120273987Abstract: Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire.Type: ApplicationFiled: June 18, 2012Publication date: November 1, 2012Inventors: Angela M. Belcher, Chuanbin Mao, Daniel J. Solis