Patents by Inventor Daniel J. Strydom

Daniel J. Strydom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition for palladium-mediated cleavage of peptides containing CXC, CXH or CHM sequences
    Patent number: 8153762
    Abstract: The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1-cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cysteine is the first amino acid of a palladium cleavage site comprising the sequence cysteine-X2-X3, wherein X2 is any amino acid, X3 is an amino acid selected from the group consisting of cysteine, histidine, or methionine, and wherein the carboxyl-terminus of the peptide is amidated upon cleavage at the X1-cysteine sequence.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: April 10, 2012
    Assignee: Medtronic, Inc.
    Inventors: Barton Holmquist, Daniel J. Strydom, Jin Seog Seo
  • Clostripain catalyzed amidation of peptides
    Patent number: 6461834
    Abstract: The invention provides a method of producing a polypeptide having a C-terminal &agr;-carboxamide group. It particularly concerns an enzymatic modification of selected substrate polypeptides which result in cleavage of the substrate polypeptide to form a product peptide with a C-terminal arginine residue having an &agr;-carboxamide group (C-terminal “Arg-NH2”). The method includes contacting an aqueous-based solution including (i) ammonia reagent and (ii) the substrate polypeptide with (iii) clostripain.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: October 8, 2002
    Assignee: Bionebraska, Inc.
    Inventors: Dan Dormady, Jay S. Stout, Daniel J. Strydom, Barton Holmquist, Fred W. Wagner