Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: A heating element including a preformed ceramic tubular body having a hollow cavity centrally located within, a heat-generating component disposed within the hollow cavity, and an air-displacement material disposed within the hollow cavity. The preformed ceramic tubular body is one of aluminum oxide, aluminum nitride, and silicon nitride ceramic. The heat-generating component may be in electrical contact with the ceramic tubular body. The air-displacement material is magnesium oxide. Further, the heat-generating component and the air-displacement material are disposed within the hollow cavity of the preformed ceramic tubular body by way of at least one of a vibrating fill and a centrifuge for compaction.

Abstract: A heating element including a preformed ceramic tubular body having a hollow cavity centrally located within, a heat-generating component disposed within the hollow cavity, and an air-displacement material disposed within the hollow cavity. The preformed ceramic tubular body is one of aluminum oxide, aluminum nitride, and silicon nitride ceramic. The heat-generating component may be in electrical contact with the ceramic tubular body. The air-displacement material is magnesium oxide. Further, the heat-generating component and the air-displacement material are disposed within the hollow cavity of the preformed ceramic tubular body by way of at least one of a vibrating fill and a centrifuge for compaction.