Patents by Inventor Daniel John CHEW
Daniel John CHEW has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240066299Abstract: The invention refers to a device for inhibiting the neural activity of a carotid sinus nerve (CSN) or carotid body of a subject, the device comprising: one or more transducers configured to apply a signal to the CSN or associated carotid body of the subject, optionally at least two such transducers; and a controller coupled to the one or more transducers, the controller controlling the signal to be applied by the one or more transducers, such that the signal inhibits the neural activity of the CSN or carotid body to produce a physiological response in the subject, wherein the physiological response is one or more of the group consisting of: an increase in insulin sensitivity in the subject, an increase in glucose tolerance in the subject, a decrease in (fasting) plasma glucose concentration in the subject, a reduction in subcutaneous fat content in the subject, and a reduction in obesity in the subject.Type: ApplicationFiled: February 1, 2023Publication date: February 29, 2024Inventors: Silvia Margarida Vilares Santos Conde, Daniel John Chew, Hans Jakob Kristoffer Famm, Maria Pedro Sucena Guarino, Brad Holinski, Sonal Patel
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Publication number: 20230347140Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: ApplicationFiled: June 26, 2023Publication date: November 2, 2023Inventors: Matteo Donega, Daniel John Chew, Margarita J. Vervoordeldonk, Isha Gupta
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Publication number: 20230285752Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.Type: ApplicationFiled: April 28, 2023Publication date: September 14, 2023Inventors: Daniel John Chew, Matteo Donega, Isha Gupta
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Publication number: 20230271010Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.Type: ApplicationFiled: April 27, 2023Publication date: August 31, 2023Inventors: Margarita J. Vervoordeldonk, Eric Irwin, Daniel John Chew, Matteo Donega, Cindy Cleypool, Isha Gupta
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Patent number: 11738196Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.Type: GrantFiled: July 25, 2022Date of Patent: August 29, 2023Assignee: Galvani Bioelectronics LimitedInventors: Margarita J. Vervoordeldonk, Eric Irwin, Daniel John Chew, Matteo Donega, Cindy Cleypool, Isha Gupta
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Patent number: 11724108Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.Type: GrantFiled: July 25, 2022Date of Patent: August 15, 2023Assignee: Galvani Bioelectronics LimitedInventors: Daniel John Chew, Matteo Donega, Isha Gupta
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Patent number: 11724102Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: GrantFiled: July 25, 2022Date of Patent: August 15, 2023Assignee: Galvani Bioelectronics LimitedInventors: Matteo Donega, Daniel John Chew, Margarita J. Vervoordeldonk, Isha Gupta
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Patent number: 11577080Abstract: The invention refers to a device for inhibiting the neural activity of a carotid sinus nerve (CSN) or carotid body of a subject, the device comprising: one or more transducers configured to apply a signal to the CSN or associated carotid body of the subject, optionally at least two such transducers; and a controller coupled to the one or more transducers, the controller controlling the signal to be applied by the one or more transducers, such that the signal inhibits the neural activity of the CSN or carotid body to produce a physiological response in the subject, wherein the physiological response is one or more of the group consisting of: an increase in insulin sensitivity in the subject, an increase in glucose tolerance in the subject, a decrease in (fasting) plasma glucose concentration in the subject, a reduction in subcutaneous fat content in the subject, and a reduction in obesity in the subject.Type: GrantFiled: November 3, 2015Date of Patent: February 14, 2023Assignees: Presidio Medical, Inc., Faculdade De Ciências Médicas Da Universidade Nova De LisboaInventors: Silvia Margarida Vilares Santos Conde, Daniel John Chew, Hans Jakob Kristoffer Famm, Maria Pedro Sucena Guarino, Brad Holinski, Sonal Patel
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Publication number: 20220409895Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.Type: ApplicationFiled: July 25, 2022Publication date: December 29, 2022Inventors: Margarita J. Vervoordeldonk, Eric Irwin, Daniel John Chew, Matteo Donega, Cindy Cleypool, Isha Gupta
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Publication number: 20220409890Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: ApplicationFiled: July 25, 2022Publication date: December 29, 2022Inventors: Matteo Donega, Daniel John Chew, Margarita J. Vervoordeldonk, Isha Gupta
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Publication number: 20220401731Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: ApplicationFiled: July 25, 2022Publication date: December 22, 2022Inventors: Daniel John Chew, Matteo Donega, Isha Gupta
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Publication number: 20220401734Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.Type: ApplicationFiled: July 25, 2022Publication date: December 22, 2022Inventors: Matteo Donega, Daniel John Chew, Isha Gupta
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Patent number: 11464978Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: GrantFiled: December 20, 2018Date of Patent: October 11, 2022Assignee: Galvani Bioelectronics LimitedInventors: Daniel John Chew, Matteo Donega, Isha Gupta
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Patent number: 11452867Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: GrantFiled: December 20, 2018Date of Patent: September 27, 2022Assignee: Galvani Bioelectronics LimitedInventors: Matteo Donega, Daniel John Chew, Margarita J. Vervoordeldonk, Isha Gupta
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Patent number: 11446502Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.Type: GrantFiled: December 20, 2018Date of Patent: September 20, 2022Assignee: Galvani Bioelectronics LimitedInventors: Matteo Donega, Daniel John Chew, Isha Gupta
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Patent number: 11446496Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.Type: GrantFiled: December 20, 2018Date of Patent: September 20, 2022Assignee: Galvani Bioelectronics LimitedInventors: Margarita J. Vervoordeldonk, Eric Irwin, Daniel John Chew, Matteo Donega, Cindy Cleypool, Isha Gupta
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Publication number: 20220080208Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period. Preferably, the time interval is a sum of the first time period and a buffer time period for allowing the nerve to recover from stimulation.Type: ApplicationFiled: December 13, 2019Publication date: March 17, 2022Inventors: David Karl Lee Peterson, Daniel John Chew, Matteo Donega, Xu Meng
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Publication number: 20210393949Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.Type: ApplicationFiled: February 26, 2021Publication date: December 23, 2021Applicants: GALVANI BIOELECTRONICS LIMITED, ACADEMISCH MEDISCH CENTRUMInventors: Daniel John CHEW, Wouter Jacob DE JONGE, Hans Jakob Kristoffer FAMM, Sonal PATEL, Olaf WELTING
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Patent number: 10974041Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.Type: GrantFiled: April 22, 2016Date of Patent: April 13, 2021Assignees: GALVANI BIOELECTRONICS LIMITED, ACADEMISCH MEDISCH CENTRUMInventors: Daniel John Chew, Wouter Jacob De Jonge, Hans Jakob Kristoffer Famm, Sonal Patel, Olaf Welting
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Publication number: 20210093862Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.Type: ApplicationFiled: December 20, 2018Publication date: April 1, 2021Inventors: MARGRIET VERVOORDELDONK, ERIC IRWIN, DANIEL JOHN CHEW, MATTEO DONEGA, CINDY CLEYPOOL, ISHA GUPTA