Patents by Inventor Daniel John Turner
Daniel John Turner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210147904Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.Type: ApplicationFiled: June 16, 2020Publication date: May 20, 2021Applicant: Oxford Nanopore Technologies Ltd.Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
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Publication number: 20210079460Abstract: A biochemical analysis system analyses polymers by taking measurements of a polymer from a sensor element comprising a nanopore during translocation of the polymer through the nanopore. When a polymer has partially translocated, the series of measurements is analysed using reference data derived from a reference sequence to provide a measure of similarity. Responsive to the measure of similarity, the sensor element may be selectively operated to eject the polymer and thereby make the nanopore available to receive a further polymer. Where the biochemical analysis system comprises an array of sensor elements and is takes measurements from sensor elements selected in a multiplexed manner, responsive to the measure of similarity, the biochemical analysis system ceases taking measurements from the currently selected sensor element and to starts taking measurements from a newly selected sensor element.Type: ApplicationFiled: May 12, 2020Publication date: March 18, 2021Applicant: Oxford Nanopore Technologies Ltd.Inventors: Stuart William Reid, Gavin Harper, Clive Gavin Brown, Daniel John Turner, Andrew John Heron, Christopher James Wright
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Publication number: 20210018500Abstract: The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.Type: ApplicationFiled: June 30, 2020Publication date: January 21, 2021Applicant: Oxford Nanopore Technologies LimitedInventors: Daniel John Turner, Daniel George Fordham, Roger Charles Gill, Clive Gavin Brown, Stuart Reid, James Anthony Clarke, James White
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Patent number: 10760114Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.Type: GrantFiled: October 6, 2015Date of Patent: September 1, 2020Assignee: Oxford Nanopore Technologies Ltd.Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
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Patent number: 10739341Abstract: The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.Type: GrantFiled: February 14, 2013Date of Patent: August 11, 2020Assignee: Oxford Nanopore Technologies LimitedInventors: Daniel John Turner, Daniel George Fordham, Roger Charles Gill, Clive Gavin Brown, Stuart Reid, James Anthony Clarke, James White
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Patent number: 10724073Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.Type: GrantFiled: October 6, 2015Date of Patent: July 28, 2020Assignee: Oxford Nanopore Technologies Ltd.Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
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Patent number: 10689697Abstract: Analysis Of A Polymer A biochemical analysis system analyses polymers by taking measurements of a polymer from a sensor element comprising a nanopore during translocation of the polymer through the nanopore. When a polymer has partially translocated, the series of measurements is analysed using reference data derived from a reference sequence to provide a measure of similarity. Responsive to the measure of similarity, the sensor element may be selectively operated to eject the polymer and thereby make the nanopore available to receive a further polymer. Where the biochemical analysis system comprises an array of sensor elements and is takes measurements from sensor elements selected in a multiplexed manner, responsive to the measure of similarity, the biochemical analysis system ceases taking measurements from the currently selected sensor element and to starts taking measurements from a newly selected sensor element.Type: GrantFiled: October 16, 2015Date of Patent: June 23, 2020Assignee: Oxford Nanopore Technologies Ltd.Inventors: Stuart William Reid, Gavin Harper, Clive Gavin Brown, Daniel John Turner, Andrew John Heron, Christopher James Wright
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Patent number: 10640295Abstract: A conveyor assembly having a conveyor for moving containers in a preselected direction. The conveyor assembly includes one or more lane guide elements, for at least partially defining one or more lanes along which the containers are movable by the conveyor. Each lane has a lane width that is transverse to the preselected direction. The conveyor assembly also includes one or more point subassemblies, connected with the lane guide elements, and one or more point subassembly cross-members on which the point subassemblies are mounted. The point subassembly is transversely movable on one or the point subassembly cross-members relative to the preselected direction, to move the lane guide element to which it is attached, to adjust the lane width of the lane defined thereby.Type: GrantFiled: May 7, 2019Date of Patent: May 5, 2020Assignee: Septimatech Group Inc.Inventors: Daniel John Turner, Jeffrey Christopher Dodge
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Publication number: 20200087724Abstract: The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also related to new methods of characterising target polynucleotides.Type: ApplicationFiled: August 14, 2019Publication date: March 19, 2020Applicant: Oxford Nanopore Technologies Ltd.Inventors: Andrew John Heron, Clive Gavin Brown, Rebecca Victoria Bowen, James White, Daniel John Turner, Joseph Hargreaves Lloyd, Christopher Peter Youd
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Publication number: 20200063199Abstract: The invention relates to a new method of characterising a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNA polynucleotide has been modified to increase DNA helicase binding thereto.Type: ApplicationFiled: September 19, 2019Publication date: February 27, 2020Applicant: Oxford Nanopore Technologies Ltd.Inventors: Daniel Ryan Garalde, Andrew John Heron, Lakmal Jayasinghe, Daniel John Turner, James White
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Patent number: 10480026Abstract: The invention relates to a new method of characterizing a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNA polynucleotide has been modified to increase DNA helicase binding thereto.Type: GrantFiled: October 19, 2015Date of Patent: November 19, 2019Assignee: Oxford Nanopore Technologies Ltd.Inventors: Daniel Ryan Garalde, Andrew John Heron, Lakmal Jayasinghe, Daniel John Turner, James White
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Patent number: 10385389Abstract: The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also relates to new methods of characterizing target polynucleotides.Type: GrantFiled: January 22, 2015Date of Patent: August 20, 2019Assignee: Oxford Nanopore Technologies Ltd.Inventors: Andrew John Heron, Clive Gavin Brown, Rebecca Victoria Bowen, James White, Daniel John Turner, Joseph Hargreaves Lloyd, Christopher Peter Youd
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Publication number: 20190249231Abstract: A method for determining the presence, absence or amount of two or more target polynucleotides in a sample comprising additional components, the method comprising: (i) contacting the sample with a panel of two or more probes under conditions suitable for hybridisation of the target polynucleotides to the probes, wherein: (a) each probe comprises a non-hybridisation region and a hybridisation region that specifically hybridises to one of the target polynucleotides to form a hybridised probe; and (b) the hybridisation region of a probe of the panel comprises one or more non-natural nucleotides; (ii) contacting the sample prepared in step (i) with a transmembrane pore through which a single stranded polynucleotide but not a double stranded polynucleotide can pass and applying a potential difference to the transmembrane pore such that the hybridised probes in the sample interact with the pore; (iii) measuring current blockades having a duration within a defined window, wherein: (a) the one or more non-natural nucType: ApplicationFiled: October 20, 2017Publication date: August 15, 2019Applicant: Oxford Nanopore Technologies LimitedInventors: Nicholas Antony Smith, Daniel John Turner, Daniel George Fordham, James White
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Publication number: 20190211390Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.Type: ApplicationFiled: January 9, 2019Publication date: July 11, 2019Applicant: Oxford Nanopore Technologies Ltd.Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White
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Patent number: 10221450Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterizing target polynucleotides using helicases.Type: GrantFiled: January 22, 2014Date of Patent: March 5, 2019Assignee: Oxford Nanopore Technologies Ltd.Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White
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Patent number: 9995728Abstract: The invention relates to a new method of determining in a sample the presence, absence or concentration of one or more target analytes, such as micro-ribonucleic acids (microRNAs or miRNAs). The invention may therefore relate to a multiplex assay for determining the presence or absence of each target analyte in a group of multiple analytess. The invention uses one or more probes comprising a quadruplex and transmembrane pores.Type: GrantFiled: November 6, 2013Date of Patent: June 12, 2018Assignee: Oxford Nanopore Technologies Ltd.Inventors: Daniel George Fordham, Nicholas Smith, Daniel John Turner
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Publication number: 20170253910Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.Type: ApplicationFiled: October 6, 2015Publication date: September 7, 2017Applicant: Oxford Nanopore Technologies Ltd.Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
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Publication number: 20170253923Abstract: The invention relates to a new method of characterising FIG. 3 a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNA polynucleotide has been modified to increase DNA helicase binding thereto.Type: ApplicationFiled: October 19, 2015Publication date: September 7, 2017Applicant: Oxford Nanopore Technologies Ltd.Inventors: Daniel Ryan Garalde, Andrew John Heron, Lakmal Jayasinghe, Daniel John Turner, James White
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Publication number: 20170233804Abstract: Analysis Of A Polymer A biochemical analysis system analyses polymers by taking measurements of a polymer from a sensor element comprising a nanopore during translocation of the polymer through the nanopore. When a polymer has partially translocated, the series of measurements is analysed using reference data derived from a reference sequence to provide a measure of similarity. Responsive to the measure of similarity, the sensor element may be selectively operated to eject the polymer and thereby make the nanopore available to receive a further polymer. Where the biochemical analysis system comprises an array of sensor elements and is takes measurements from sensor elements selected in a multiplexed manner, responsive to the measure of similarity, the biochemical analysis system ceases taking measurements from the currently selected sensor element and to starts taking measurements from a newly selected sensor element.Type: ApplicationFiled: October 16, 2015Publication date: August 17, 2017Applicant: Oxford Nanopore Technologies Ltd.Inventors: Stuart William Reid, Gavin Harper, Clive Gavin Brown, Daniel John Turner, Andrew John Heron, Christopher James Wright
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Publication number: 20170107569Abstract: The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also relates to new methods of characterising target polynucleotides.Type: ApplicationFiled: January 22, 2015Publication date: April 20, 2017Applicant: Oxford Nanopore Technologies Ltd.Inventors: Andrew John Heron, Clive Gavin Brown, Rebecca Victoria Bowen, James White, Daniel John Turner, Joseph Hargreaves Lloyd, Christopher Peter Youd