Abstract: Systems and methods are provided to collect biometrically-verified actigraphy data, comprising: obtaining and processing a subject's measured biometric input from a biometric sensor to generate a current biometric signature of the subject; verifying the subject's identity by comparing the current biometric signature to one previously obtained from a database and evaluating a proximity metric of the current biometric signature of the subject to the previously obtained biometric signature from the database; if the subject passes identity verification, obtaining actigraphy data from an actigraphy sensor worn by the subject; at one or more times while obtaining the actigraphy data, repeating the steps of obtaining and processing a subject's measured biometric input from a biometric sensor to generate a current biometric signature of the subject, and verifying the identity of the subject to ensure that the identity of the subject passes the identity verification at the one or more times.

Abstract: Methods are provided for calibrating stimulus-response test systems which include a stimulus output device for delivering a stimulus to a subject; and a response input device for receiving a response from the subject.

Abstract: Method are provided for evaluating reaction time data obtained from a stimulus-response testing system. One exemplary method comprises: obtaining reaction time data, the reaction time data comprising a plurality of reaction times, each reaction time comprising an estimate of a time required for a subject to respond to a corresponding stimulus event; assigning a weight to each reaction time in the reaction time data in accordance with a weighting function, the weighting function comprising a rule that defines a mapping between reaction times and corresponding weights; and determining a weighted reaction time metric based at least in part on a sum of the weights assigned to the reaction times in the reaction time data.

Abstract: Aspects of the invention provide systems and methods for controllably adjusting the circadian pacemaker cycle of a subject using light (or other stimulus) through application of model-based predictive control techniques. This approach allows the use of closed-loop feedback to compensate for modeling errors, unknown initial conditions and disturbances. It also allows an optimal level of light (or other stimulus) to be generated based on minimization of a cost function. The cost function may incorporate a term associated with tracking errors and a term associated with the amount of light used. The tracking function may be minimized subject to one or more constraints which may include a minimum and maximum amount of light (or other stimulus).

Abstract: A method and apparatus are disclosed for a waking system that wakes an individual gradually over a period of time in order to promote the wellness of that individual. The user sets the system controller with a desired final wakeup time, which is the time that the user must be awake. When the actual time reaches a stimulus introduction time (i.e. some time prior to the desired final wakeup time), the system controller causes the introduction of stimulus. The system further comprises a detection system that measures a parameter correlated to the individual's sleep level (preferably motion). This measured parameter is then used in a feedback loop to control the level of stimulus experienced by the individual. In this manner, the user is woken gradually over a period of time between the stimulus introduction time and the desired final wakeup time, without introducing any sudden shocks to the user's physiological systems.

Abstract: A method and apparatus are disclosed for a waking system that wakes an individual gradually over a period of time in order to promote the wellness of that individual. The user sets the system controller with a desired final wakeup time, which is the time that the user must be awake. When the actual time reaches a stimulus introduction time (i.e. some time prior to the desired final wakeup time), the system controller causes the introduction of stimulus. The system further comprises a detection system that measures a parameter correlated to the individual's sleep level (preferably motion). This measured parameter is then used in a feedback loop to control the level of stimulus experienced by the individual. In this manner, the user is woken gradually over a period of time between the stimulus introduction time and the desired final wakeup time, without introducing any sudden shocks to the user's physiological systems.