Patents by Inventor Daniel K. Hsu

Daniel K. Hsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MITIGATION OF DISEASE BY INHIBITION OF GALECTIN-12
    Publication number: 20140328847
    Abstract: It has now been discovered that mice with an ablated galectin-12 gene exhibit enhanced fat mobilization (lipolysis), have reduced adipose tissue mass, improved insulin sensitivity and glucose tolerance, and increased mitochondrial respiration. Inhibition of galectin-12 activity can therefore be used to reduce, mitigate, inhibit and/or prevent obesity, type 2 diabetes, metabolic diseases, mitochondrial diseases, other disease conditions associated with and/or caused by the abnormal expression or overexpression of galectin-12, and other disease conditions with normal galectin-12 expression but will benefit from galectin-12 inhibition.
    Type: Application
    Filed: October 2, 2012
    Publication date: November 6, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ri-Yao Yang, Fu-Tong Liu, Lan Yu, Daniel K. Hsu
  • Methods of modulating cell migration using galectin-3
    Patent number: 7186681
    Abstract: The present invention relates to methods of modulating cell migration, particularly, monocyte, neutrophil or macrophage migration, using galectin-3, galectin-3 binding polypeptide, or galectin-3 receptor binding polypeptide. Specifically provided are methods for increasing cell migration to sites of inflammation, infection or a tumor. Also provided are methods for identifying agents that modulate galectin-3 mediated migration, compositions containing galectin-3 or a functional subsequence thereof, and microfabricated devices that deliver galectin-3 or functional galectin-3 subsequences.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: March 6, 2007
    Assignee: La Jolla Institute for Allergy and Immunology
    Inventors: Fu-Tong Liu, Hideki Sano, Daniel K. Hsu
  • Galectin expression is induced in cirrhotic liver and hepatocellular carcinoma
    Publication number: 20020155513
    Abstract: The present invention relates to the discovery of a marker for liver disease. Novel diagnostics, prognostics, therapeutics and methods of use of the foregoing for the treatment and prevention of hepatocellular carcinoma are also disclosed.
    Type: Application
    Filed: October 10, 2001
    Publication date: October 24, 2002
    Inventors: Daniel K. Hsu, Fu-Tong Liu, Christopher Dowling
  • Monocyte chemoattractant activity of galectin-3
    Publication number: 20020044932
    Abstract: The present invention relates to methods of modulating cell migration, particularly, monocyte, neutrophil or macrophage migration, using galectin-3, galectin-3 binding polypeptide, or galectin-3 receptor binding polypeptide. Specifically provided are methods for increasing cell migration to sites of inflammation, infection or a tumor. Also provided are methods for identifying agents that modulate galectin-3 mediated migration, compositions containing galectin-3 or a functional subsequence thereof, and microfabricated devices that deliver galectin-3 or functional galectin-3 subsequences.
    Type: Application
    Filed: March 13, 2001
    Publication date: April 18, 2002
    Inventors: Fu-Tong Liu, Hideki Sano, Daniel K. Hsu