Patents by Inventor Daniel Kacy CULLEN

Daniel Kacy CULLEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240359010
    Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
    Type: Application
    Filed: July 3, 2024
    Publication date: October 31, 2024
    Inventors: Daniel Kacy Cullen, James P. Harris, John A. Wolf, Han-Chiao Isaac Chen, Douglas H. Smith, Mijail Serruya
  • Publication number: 20240341765
    Abstract: A system and method for repairing a damaged peripheral nerve is provided. A coupler includes a stabilizing assembly applied to a distal end of a damaged area of the nerve and applied to a proximal end of the damaged area, the coupler adapted so that the proximal end and the distal end are maintained in a stabile abutting relationship in which nerve repair can occur. A chamber is placed in proximity to the damaged area, having a therapeutic agent. Illustratively, the distal end and the proximal end are severed from each other. The coupler can define one of (a) coupler halves that surround the proximal end and the distal end and allow fixing members to be applied to the proximal end and the distal end and (b) cuffs that engage, and are fixed to, each of the proximal end and the distal end and are engaged by overlying coupler halves.
    Type: Application
    Filed: August 2, 2022
    Publication date: October 17, 2024
    Inventors: Joseph M. Rosen, Daniel Kacy Cullen, Justin C. Burrell, Basile Montagnese, Theodore Bronk, Joshua De La Cruz, Gracyn Campbell, Yutong Xia, Reeham M. Choudhury
  • Patent number: 12090323
    Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: September 17, 2024
    Assignees: The Trustees of the University of Pennsylvania, Thomas Jefferson University
    Inventors: Daniel Kacy Cullen, James P. Harris, John A. Wolf, Han-Chiao Isaac Chen, Douglas H. Smith, Mijail Serruya
  • Publication number: 20240277901
    Abstract: In various aspects and embodiments, the invention provides a tissue engineered neuromuscular interface comprising: an extracellular matrix core; the extracellular matrix core comprising: a population of neurons at a first end of the extracellular matrix core, the population of neurons having axons extending at least a portion of the way along the extracellular matrix core; wherein the population of neurons is selected from the group consisting of one or more motor neurons, one or more motor neurons co-cultured with one or more sensory neurons, and a co-aggregate comprising one or more motor neurons and one or more sensory neurons.
    Type: Application
    Filed: June 10, 2022
    Publication date: August 22, 2024
    Inventors: Daniel Kacy Cullen, Justin C. Burrell, Joseph M. Rosen
  • Publication number: 20240269348
    Abstract: Provided herein is a method of obtaining astrocytes from gingiva-derived mesenchymal stem cells (GDMSC). Also disclosed herein are systems comprising a biocompatible construct and a plurality of astrocytes obtained from a method disclosed herein and methods of making and using the same.
    Type: Application
    Filed: June 3, 2022
    Publication date: August 15, 2024
    Inventors: Daniel Kacy Cullen, John C. O'Donnell, Erin M. Purvis, Anh Le, Qunzhou Zhang
  • Publication number: 20240252726
    Abstract: In various aspects and embodiments the present disclosure provides a construct comprising a pre-formed neural network, the construct comprising a micro-column comprising an outer sheath comprising a hyaluronic acid (HA) hydrogel, and a core comprising an extracellular matrix (ECM); a plurality of neurons within the micro-column. The present disclosure further provides methods of making and using the same.
    Type: Application
    Filed: May 18, 2022
    Publication date: August 1, 2024
    Inventors: Daniel Kacy Cullen, Wisberty J. Gordian-Velez, H. Isaac Chen, Jason A. Burdick
  • Publication number: 20240245728
    Abstract: Provided herein are living scaffolds for peripheral nerve regeneration, the living scaffolds including tissue engineered nerve grafts (TENGs) programmed to express neurogenic growth factors with temporal and spatial control. Further provided herein are compositions and methods for facilitating nerve regeneration, such as compositions and methods comprising TENGs modified to express a neurotrophic growth factor.
    Type: Application
    Filed: January 19, 2024
    Publication date: July 25, 2024
    Inventors: Daniel Kacy Cullen, Hannah Hoeun Lee, Robert Shultz, Sam Lien
  • Publication number: 20240139377
    Abstract: Provided herein is a system, e.g., a living electrode, comprising a biocompatible construct comprising a matrix, and a plurality of auditory neurons. Also disclosed herein are methods of making the system, and methods of using the same for implantation in a subject, for modulating an auditory neuron in the subject, and/or for treating or alleviating a symptom of a hearing loss disorder. Further provided herein are kits comprising the system described herein.
    Type: Application
    Filed: February 23, 2022
    Publication date: May 2, 2024
    Inventors: Daniel Kacy Cullen, Jason Brant, Oladayo Adewole
  • Publication number: 20230398088
    Abstract: In one aspect, the present disclosure relates to a composition comprising a therapeutically effective amount a polyunsaturated fatty acid (PUFA). In another aspect, the present disclosure relates to a method of reducing a brain injury in a subject having an elevated risk of a traumatic brain injury or concussion, the method comprising: prophylactically administering to the subject a composition comprising a therapeutically effective amount of a PUFA. In yet another aspect, the present disclosure relates to sports drinks and dietary supplements comprising a PUFA. In some embodiments, the PUFA is an omega-6 PUFA such as omega-6 docosapentaenoic acid.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 14, 2023
    Inventors: Daniel Kacy Cullen, Carolyn E. Keating, Kevin D. Browne
  • Publication number: 20220401621
    Abstract: In various aspects and embodiments, the present invention provides methods for maintaining motor neuron health in the spinal cord and pro-regenerative capacity of a proximal nerve segment subsequent to a nerve injury in a subject in need thereof, the methods comprising transplanting a stretch-grown tissue engineered nerve graft (TENG) into a proximal site contacting the proximal nerve segment.
    Type: Application
    Filed: November 18, 2020
    Publication date: December 22, 2022
    Inventors: Daniel Kacy Cullen, Justin C. Burrell, Joseph Cole Maggiore
  • Publication number: 20220010269
    Abstract: In various aspects and embodiments, the present invention provides methods for preparing innervated tissue. In various embodiments the invention further provides innervated tissue generated using the methods described herein. In various embodiments the inclusion of optogenetically transducible TENGs or Micro-TENNs in the innervated tissue allows the modulation of tissue or organs by using light to stimulate the optogenetically transducible TENGs or Micro-TENNs.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 13, 2022
    Inventors: Daniel Kacy Cullen, Suradip Das, Wisberty Gordian-Velez
  • Publication number: 20210393960
    Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
    Type: Application
    Filed: June 25, 2021
    Publication date: December 23, 2021
    Inventors: Daniel Kacy Cullen, James P. Harris, John A. Wolf, Han-Chiao Isaac Chen, Douglas H. Smith, Mijail Serruya
  • Publication number: 20200230293
    Abstract: The present invention includes a composition comprising a tissue engineered axonal tract, as well as a method of making it. The invention also includes methods for treating nerve injury in a subject by contacting the site of nerve injury with a tissue engineered axonal tract, wherein the axons from the tissue engineered axonal tract fuse with axons from the subject.
    Type: Application
    Filed: October 5, 2018
    Publication date: July 23, 2020
    Inventor: Daniel Kacy CULLEN
  • Patent number: 10525085
    Abstract: The invention relates to methods and compositions for maintaining the pro-regenerative capacity of distal nerve segments following nerve injury.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: January 7, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Douglas H. Smith, Daniel Kacy Cullen, John A. Wolf
  • Publication number: 20190126043
    Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
    Type: Application
    Filed: April 14, 2017
    Publication date: May 2, 2019
    Inventors: Daniel Kacy Cullen, James P. Harris, John A. Wolf, H. Isaac Chen, Douglas H. Smith, Mijail Serruya
  • Publication number: 20180214492
    Abstract: The invention relates to methods and compositions for maintaining the pro-regenerative capacity of distal nerve segments following nerve injury.
    Type: Application
    Filed: January 5, 2018
    Publication date: August 2, 2018
    Inventors: Douglas H. SMITH, Daniel Kacy CULLEN, John A. WOLF