Patents by Inventor Daniel Kage

Daniel Kage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and system for characterizing particles using an angular detection in a flow cytometer
    Patent number: 11841314
    Abstract: The invention relates to a method and system for characterizing particles using a flow cytometer comprising detecting radiated light from the particles using two or more detectors positioned to allow for the detection in two or more angular directions and generating a waveform, as a digital representation for the detected radiated light for each of said angulation direction. The waveforms are transformed using one or more basis functions to obtain one or more coefficients characterizing the waveform. The one or more coefficients characterizing the waveform preferably correspond to properties of the particle(s), thereby enabling analysis of physical properties of the particles (such as size, shape, refractive index) or biological properties of the particles (such as cell type, cell cycle state or localization or distribution of molecules within the cell and/or on the cell surface). In preferred embodiments the method and system are used for a label-free sorting of particles, in particular biological cells.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: December 12, 2023
    Assignees: Deutsches Rheuma-Forschungszentrum Berlin, A.P.E Angewandte Physik & Elektronik GmbH
    Inventors: Toralf Kaiser, Daniel Kage, Claudia Giesecke-Thiel, Konrad von Volkmann
  • METHOD AND SYSTEM FOR CHARACTERIZING PARTICLES USING AN ANGULAR DETECTION IN A FLOW CYTOMETER
    Publication number: 20220003660
    Abstract: The invention relates to a method and system for characterizing particles using a flow cytometer comprising detecting radiated light from the particles using two or more detectors positioned to allow for the detection in two or more angular directions and generating a waveform, as a digital representation for the detected radiated light for each of said angulation direction. The waveforms are transformed using one or more basis functions to obtain one or more coefficients characterizing the waveform. The one or more coefficients characterizing the waveform preferably correspond to properties of the particle(s), thereby enabling analysis of physical properties of the particles (such as size, shape, refractive index) or biological properties of the particles (such as cell type, cell cycle state or localization or distribution of molecules within the cell and/or on the cell surface). In preferred embodiments the method and system are used for a label-free sorting of particles, in particular biological cells.
    Type: Application
    Filed: June 28, 2021
    Publication date: January 6, 2022
    Inventors: Toralf Kaiser, Daniel Kage, Claudia Giesecke-Thiel, Konrad von Volkmann