Abstract: The present invention relates to a base editing compound comprising or consisting of (a) a Cas protein, and, covalently connected therewith; (b) a nucleobase-modifying enzyme, wherein the covalent connection of (a) and (b) is (i) direct; (ii) provided by a peptide comprising at least one Pro residue, said peptide having a length between 1 and 20 preferably between 1 and 15 amino acids; or (iii) provided by a non-peptidic linker, said non-peptidic linker being a small organic molecule comprising one or more double bonds, one or more triple bonds, and/or one or more aromatic rings.

Abstract: An arrow rest arrangement in a capture style arrow rest for an archery bow. The arrow capture portion may be formed as an inverted brush. The arrow capture portion defines a central aperture through which an arrow shaft extends. The aperture may include two straight slanted lower side portions forming a “V” profile to support the arrow.

Abstract: An arrow rest arrangement in a capture style arrow rest for an archery bow. The arrow capture portion may be formed as an inverted brush. The arrow capture portion defines a central aperture through which an arrow shaft extends. The aperture may include two straight slanted lower side portions forming a “V” profile to support the arrow.

Abstract: An arrow rest arrangement in a capture style arrow rest for an archery bow. The arrow capture portion may be formed as an inverted brush. The arrow capture portion defines a central aperture through which an arrow shaft extends. The aperture may include two straight slanted lower side portions forming a “V” profile to support the arrow.

Abstract: An arrow rest arrangement in a capture style arrow rest for an archery bow. The arrow capture portion may be formed as an inverted brush. The arrow capture portion defines a central aperture through which an arrow shaft extends. The aperture may include two straight slanted lower side portions forming a “V” profile to support the arrow.

Abstract: An arrow rest arrangement in a capture style arrow rest for an archery bow. The arrow capture portion may be formed as an inverted brush. The arrow capture portion defines a central aperture through which an arrow shaft extends. The aperture may include two straight slanted lower side portions forming a “V” profile to support the arrow.

Abstract: A serve-less peep sight is configured for use with an archery bow with bowstring fibers. The fibers are separated into two groups that diverge at an upper junction and converge at a lower junction. The peep sight is installed with the bowstring fibers extending around an upper portion and a lower portion and with the fibers crossing within a transverse channel. The peep sight is locked in place when the bowstring is under tension without the need to use serving material.

Abstract: An arrow rest arrangement in a capture style arrow rest for an archery bow. The arrow capture portion may be formed as an inverted brush. The arrow capture portion defines a central aperture through which an arrow shaft extends. The aperture may include two straight slanted lower side portions forming a “V” profile to support the arrow.

Abstract: The present invention relates to a method of generating eukaryotic cells suitable for the expression of transgenes in said cells comprising (a) introducing a nucleic acid encoding a selectable marker responsive to a selecting agent into the nucleus of cells, wherein the level of expression of said selectable marker is proportional to the level of phenotypic responsiveness to said selecting agent; (b) selecting, among the cells obtained in step (a), for cells with a detectable expression of said selectable marker; (c) optionally propagating the cells selected for in step (b); (d) mutagenizing the cells selected for in step (b) or propagated in step (c) or allowing for the appearance of spontaneous mutations in the cells selected for in step (b) or propagated in step (c); and (e) selecting for cells displaying an increased expression of said selectable marker compared to the expression obtained in step (b).