Abstract: A segmental crimper comprises at least three crimper segments and an actuator. The crimper segments are arranged circumferentially about a crimper axis that defines axial and radial directions. The crimper segments are movable relative to each other in a manner such that the crimper segments collectively define a variable size aperture that is aligned with the crimper axis. Each of the crimper segments comprises a radio frequency heating element. The actuator is operatively connected to the crimper segments in a manner such that movement of the actuator causes all of the crimper segments to simultaneously move relative to each other and alters the size of the aperture.

Abstract: A microwave ablation system and method is disclosed comprising a balloon catheter apparatus and a control system. The balloon catheter apparatus comprises a catheter configured to house a coaxial cable and one or more coolant channels, an inflatable balloon located at the distal end of the catheter, and an antenna positioned in the inflatable balloon and in communication with the coaxial cable. The control system comprises a fluid pump configured to introduce fluid into a proximal end of the catheter, a power amplifier capable of generating microwave energy for delivery to the target tissue zone for at least one energy application cycle ranging from 60 seconds to 600 seconds at a frequency ranging from 2.4 GHz to 2.5 GHz, and a computer system configured to monitor and/or regulate the delivery of microwave energy to the target tissue, the fluid pump, at least one sensor, and antenna reflected power.

Abstract: A segmental crimper comprises at least three crimper segments and an actuator. The crimper segments are arranged circumferentially about a crimper axis that defines axial and radial directions. The crimper segments are movable relative to each other in a manner such that the crimper segments collectively define a variable size aperture that is aligned with the crimper axis. Each of the crimper segments comprises a radio frequency heating element. The actuator is operatively connected to the crimper segments in a manner such that movement of the actuator causes all of the crimper segments to simultaneously move relative to each other and alters the size of the aperture.

Abstract: A microwave ablation system and method is disclosed comprising a balloon catheter apparatus and a control system. The balloon catheter apparatus comprises a catheter configured to house a coaxial cable and one or more coolant channels, an inflatable balloon located at the distal end of the catheter, and an antenna positioned in the inflatable balloon and in communication with the coaxial cable. The control system comprises a fluid pump configured to introduce fluid into a proximal end of the catheter, a power amplifier capable of generating microwave energy for delivery to the target tissue zone for at least one energy application cycle ranging from 60 seconds to 600 seconds at a frequency ranging from 2.4 GHz to 2.5 GHz, and a computer system configured to monitor and/or regulate the delivery of microwave energy to the target tissue, the fluid pump, at least one sensor, and antenna reflected power.

Abstract: A method and balloon catheter apparatus for tissue ablation is disclosed. The apparatus comprises an elongated shaft having a proximal end, a distal end, one or more central lumens, adapted for positioning in an artery; an emitter capable of emitting microwave energy positioned at the distal end; an inflatable balloon associated with the emitter at the distal end configured to allow blood to pass through the artery while the balloon is inflated; and a control system at the proximal end. The method and balloon catheter apparatus is applicable at least to renal denervation procedures.

Abstract: An apparatus for folding a catheter balloon comprises a stationary base member; a rotatable drive hub which is moveable in relation to the stationary base member; and a pleating head aligned with respect to the stationary base member and to the rotatable drive hub. The pleating head includes at least three segments, each having a proximal end and an angled distal end with at least one angled side face terminating in an edge of a predetermined length. Each segment has a centerline between the proximal and distal ends, each segment having a proximal point and a distal point, and the proximal point being pivotally coupled by pins to the stationary base member and the distal point being pivotally coupled by pins to the rotatable hub member. The segments are arranged so that the segment distal ends are disposed adjacent to and a predetermined distance away from a central point and defining a central aperture with a spiral-pleat dimension having at least three channels in communication with a central aperture.

Abstract: An apparatus for folding a catheter balloon comprises a stationary base member; a rotatable drive hub which is moveable in relation to the stationary base member; and a pleating head aligned with respect to the stationary base member and to the rotatable drive hub. The pleating head includes at least three segments, each having a proximal end and an angled distal end with at least one angled side face terminating in an edge of a predetermined length. Each segment has a centerline between the proximal and distal ends, each segment having a proximal point and a distal point, and the proximal point being pivotally coupled by pins to the stationary base member and the distal point being pivotally coupled by pins to the rotatable hub member. The segments are arranged so that the segment distal ends are disposed adjacent to and a predetermined distance away from a central point and defining a central aperture with a spiral-pleat dimension having at least three channels in communication with a central aperture.

Abstract: An apparatus for folding a catheter balloon comprises a stationary base member; a rotatable drive hub which is moveable in relation to the stationary base member; and a pleating head aligned with respect to the stationary base member and to the rotatable drive hub. The pleating head includes at least three segments, each having a proximal end and an angled distal end with at least one angled side face terminating in an edge of a predetermined length. Each segment has a centerline between the proximal and distal ends, each segment having a proximal point and a distal point, and the proximal point being pivotally coupled by pins to the stationary base member and the distal point being pivotally coupled by pins to the rotatable hub member. The segments are arranged so that the segment distal ends are disposed adjacent to and a predetermined distance away from a central point and defining a central aperture with a spiral-pleat dimension having at least three channels in communication with a central aperture.