Patents by Inventor Daniel Kaufmann

Daniel Kaufmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-phenyl-2-pyrimidine-amine derivatives
    Patent number: 9573928
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: February 21, 2017
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Intermediates for producing NEP inhibitors or prodrugs thereof
    Patent number: 9403766
    Abstract: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: August 2, 2016
    Assignee: NOVARTIS AG
    Inventors: David Hook, Bernard Riss, Daniel Kaufmann, Matthias Napp, Erhard Bappert, Philippe Polleux, Jonathan Medlock, Antonio Zanotti-Gerosa
  • Processes
    Publication number: 20160060217
    Abstract: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
    Type: Application
    Filed: November 12, 2015
    Publication date: March 3, 2016
    Inventors: David Hook, Bernard Riss, Daniel Kaufmann, Matthias Napp, Erhard Bappert, Philippe Polleux, Jonathan Medlock, Antonio Zanotti-Gerosa
  • Processes for producing NEP inhibitors or prodrugs thereof
    Patent number: 9227934
    Abstract: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: January 5, 2016
    Assignee: NOVARTIS AG
    Inventors: David Hook, Bernard Riss, Daniel Kaufmann, Matthias Napp, Erhard Bappert, Philippe Polleux, Jonathan Medlock, Antonio Zanotti-Gerosa
  • Processes
    Publication number: 20150246881
    Abstract: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
    Type: Application
    Filed: May 18, 2015
    Publication date: September 3, 2015
    Applicant: Novartis AG
    Inventors: David Hook, Bernard Riss, Daniel Kaufmann, Matthias Napp, Erhard Bappert, Philippe Polleux, Jonathan Medlock, Antonio Zanotti-Gerosa
  • Processes for producing NEP inhibitors or prodrugs thereof
    Patent number: 9061973
    Abstract: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: June 23, 2015
    Assignee: Novartis Pharmaceuticals Corporation
    Inventors: David Hook, Bernard Riss, Daniel Kaufmann, Matthias Napp, Erhard Bappert, Philippe Polleux, Jonathan Medlock, Antonio Zanotti-Gerosa
  • N-Phenyl-2-pyrimidine-amine Derivatives
    Publication number: 20150018552
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 15, 2015
    Applicant: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Processes
    Publication number: 20140243546
    Abstract: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
    Type: Application
    Filed: November 11, 2013
    Publication date: August 28, 2014
    Applicant: NOVARTIS AG
    Inventors: David Hook, Bernard Riss, Daniel Kaufmann, Matthias Napp, Erhard Bappert, Philippe Polleux, Jonathan Medlock, Antonio Zanotti-Gerosa
  • Manufacture process for the preparation of an iron containing phosphate adsorbent
    Publication number: 20130316018
    Abstract: The present invention relates to a new manufacture process for producing an iron containing phosphate adsorbent, in particular to a process for manufacturing and isolating an iron(III)-based phosphate adsorbent which exhibits valuable pharmacological properties.
    Type: Application
    Filed: July 31, 2013
    Publication date: November 28, 2013
    Applicant: Novartis AG
    Inventors: Daniel Kaufmann, Nicole Bieri, Ulrich Meier, Ranjit Thakur, Zdenek Zencak, Christa Hartmann, Andreas Meyer
  • Processes
    Patent number: 8580974
    Abstract: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: November 12, 2013
    Assignee: Novartis AG
    Inventors: David Hook, Bernhard Riss, Daniel Kaufmann, Matthias Napp, Erhard Bappert, Philippe Polleux, Jonathan Medlock, Antonio Zanotti-Gerosa
  • N-Phenyl-2-pyrimidine-amine Derivatives
    Publication number: 20120226039
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Application
    Filed: May 17, 2012
    Publication date: September 6, 2012
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Manufacture process
    Patent number: 8252310
    Abstract: The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: August 28, 2012
    Assignee: Novartis AG
    Inventors: Michael Ambühl, Corine Gessier-Vial, Christa Hartmann, Daniel Kaufmann, Ernst Küsters, Ulrich Meier, Andreas Meyer, Nabila Sekkat
  • Manufacture Process
    Publication number: 20120126440
    Abstract: The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 24, 2012
    Inventors: Michael Ambühl, Corine Gessier-Vial, Christa Hartmann, Daniel Kaufmann, Ernst Küsters, Ulrich Meier, Andreas Meyer, Nabila Sekkat
  • Manufacture process for the preparation of an iron containing phosphate adsorbent
    Publication number: 20110086097
    Abstract: The present invention relates to a new manufacture process for producing an iron containing phosphate adsorbent, in particular to a process for manufacturing and isolating an iron(III)-based phosphate adsorbent which exhibits valuable pharmacological properties.
    Type: Application
    Filed: June 12, 2009
    Publication date: April 14, 2011
    Inventors: Daniel Kaufmann, Nicole Bieri, Ulrich Meier, Ranjit Thakur, Zdenek Zencak, Christa Hartmann, Andreas Meyer
  • NEW PROCESSES
    Publication number: 20110046397
    Abstract: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
    Type: Application
    Filed: January 16, 2009
    Publication date: February 24, 2011
    Inventors: David Hook, Bernhard Riss, Daniel Kaufmann, Matthias Napp, Erhard Bappert, Phillippe Polleux, Jonathan Medlock, Antonio Zanotti-Gerosa
  • N-phenyl-2-pyrimidine-amine derivatives
    Patent number: 7825247
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: November 2, 2010
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • N-phenyl-2-pyrimidine-amine derivatives
    Patent number: 7816359
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: October 19, 2010
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • PROCESS FOR THE MANUFACTURE OF VALSARTAN
    Publication number: 20100249429
    Abstract: The present invention relates to a process for the manufacture of an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.
    Type: Application
    Filed: June 15, 2010
    Publication date: September 30, 2010
    Inventors: Donatienne Denni-Dischert, Hans Hirt, Dan Neville, Gottfried Sedelmeier, Anita Schnyder, Nadine Derrien, Daniel Kaufmann
  • -phenyl-2-pyrimidine-amine derivatives
    Patent number: 7579467
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: August 25, 2009
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES
    Publication number: 20090137805
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Application
    Filed: February 2, 2009
    Publication date: May 28, 2009
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Burger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier