Abstract: A pallet including top and bottom decks supported in spaced apart relationship by a plurality of post assemblies. A reinforcement assembly is encapsulated within at least one of the top or bottom deck. The reinforcement assembly includes at least one reinforcement rod having opposed ends and a plurality of reinforcement caps. Each reinforcement cap has an outer member defining a closed end and an open end and an inner compensation structure within the outer member and defining a stop surface spaced from the outer member open end such that an initial open area is defined within the outer cap member. A respective rod end is received in the initial open area. The inner compensation structure is configured to deform to accommodate a relative position change between the cap member and the reinforcement rod end.

Abstract: A pallet including top and bottom decks supported in spaced apart relationship by a plurality of post assemblies. A reinforcement assembly is encapsulated within at least one of the top or bottom deck. The reinforcement assembly includes at least one reinforcement rod having opposed ends and a plurality of reinforcement caps. Each reinforcement cap has an outer member defining a closed end and an open end and an inner compensation structure within the outer member and defining a stop surface spaced from the outer member open end such that an initial open area is defined within the outer cap member. A respective rod end is received in the initial open area. The inner compensation structure is configured to deform to accommodate a relative position change between the cap member and the reinforcement rod end.

Abstract: An image waveguide includes first and second reflective surfaces being substantially parallel and opposing each other. The waveguide receives light from an in-coupling region through the first reflective surface, the light received at a first angle of incidence with respect to the second reflective surface. A reflective end surface positioned at an end of the waveguide and offset from perpendicular to the first and second reflective surfaces reflects the light to a second angle of incidence with respect to the second reflective surface that is less than the first angle of incidence. The light exits through an out-coupling region disposed on the first reflective surface to output the light at the second angle of incidence from the waveguide out the first reflective surface.

Abstract: Provided herein are assays useful, for example, for determining the activity of a protein involved in a cellular process. In some embodiments, the activity of the protein is assessed using a nucleic acid tag, and in particular, by detecting the presence of a nucleic acid tag. Such assays can be used, for example, to study the effects of test compounds as modulators, e.g., inhibitors, agonists and antagonists, of protein activity.

Abstract: One embodiment of the present invention sets forth a technique for parallel distribution of primitives to multiple rasterizers. Multiple, independent geometry units perform geometry processing concurrently on different graphics primitives. A primitive distribution scheme delivers primitives from the multiple geometry units concurrently to multiple rasterizers at rates of multiple primitives per clock. The multiple, independent rasterizer units perform rasterization concurrently on one or more graphics primitives, enabling the rendering of multiple primitives per system clock.

Abstract: A dolly pallet assembly including a pallet having a pallet body defining a bottom surface and at least two channels therein. Each channel includes side walls and a channel bottom surface spaced a first height relative to the pallet body bottom surface. An entry into each channel is defined in the body and includes a ramped surface which slopes from a second height relative to the pallet body bottom surface at the entry to a third height relative to the pallet body bottom surface adjacent the channel bottom surface, wherein the second height is less than the first and third heights. The dolly includes a support platform with a plurality of wheel assemblies and at least one locking member, wherein the dolly is positionable relative to the pallet with the wheels received in respective channels and the locking member selectively engageable to lock the dolly relative to the pallet.

Abstract: An electronic device including a frame configured to be worn on the head of a user is disclosed. The frame can include a bridge configured to be supported on the nose of the user and a brow portion coupled to and extending away from the bridge and configured to be positioned over a side of a brow of the user. The frame can further include an arm coupled to the brow portion and extending to a free end. The first arm can be positionable over a temple of the user with the free end disposed near an ear of the user. The device can also include a transparent display affixed to the frame adjacent the brow portion and an input affixed to the frame and configured for receiving from the user an input associated with a function. Information related to the function can be presentable on the display.

Abstract: A pallet base structure including a center deck defining a support surface extending between opposed sides and having at least two lugs extending from each of the opposed sides. A pair of base side members are positioned along respective sides of the center deck. Each base side member has first and second spaced apart base legs and a support member extending between the base legs with at least two corresponding lug receiving slots defined in the support member. The respective lugs are received in the respective lug receiving slots such that the center deck support surface is aligned with an upper surface of each support member to define a planar pallet surface. A packaging system incorporating the pallet base structure is also described.

Abstract: The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.

Abstract: The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.

Abstract: Embodiments of substrates and processes for chromogenic detection, and in particular pyrazolyl dihydrogen phosphate compounds, are disclosed.

Abstract: An electronic device including a frame configured to be worn on the head of a user is disclosed. The frame can include a bridge configured to be supported on the nose of the user and a brow portion coupled to and extending away from the bridge and configured to be positioned over a side of a brow of the user. The frame can further include an arm coupled to the brow portion and extending to a free end. The first arm can be positionable over a temple of the user with the free end disposed near an ear of the user. The device can also include a transparent display affixed to the frame adjacent the brow portion and an input affixed to the frame and configured for receiving from the user an input associated with a function. Information related to the function can be presentable on the display.

Abstract: The invention concerns materials and methods relating to the use of OMD (osteomodulin) and\or PRELP (Proline/arginine-rich end leucine-rich repeat protein) expression, particularly under-expression, to discriminate cancer and non-cancer cells in a variety of cancers. The invention further provides methods and materials based on OMD and\or PRELP for use in therapy e.g. to suppress cancer initiation or development.

Abstract: Embodiments of a system, method, and kit for visualizing a nucleus are disclosed. A tissue sample is pretreated with a protease to permeabilize the nucleus, and then incubated with a nanoparticle/DNA-binding moiety conjugate. The DNA-binding moiety includes at least one DNA-binding molecule. The conjugate binds to DNA within the nucleus, and the nanoparticle is visualized, thereby visualizing the nucleus. Computer and image analysis techniques are used to evaluate nuclear features such as chromosomal distribution, ploidy, shape, size, texture features, and/or contextual features. The method may be used in combination with other multiplexed tests on the tissue sample, including fluorescence in situ hybridization. Kits for performing the method include a protease enzyme composition, a nanoparticle/DNA-binding moiety conjugate, and a reaction buffer.

Abstract: Provided herein are assays useful, for example, for determining the activity of a protein involved in a cellular process. In some embodiments, the activity of the protein is assessed using a nucleic acid tag, and in particular, by detecting the presence of a nucleic acid tag. Such assays can be used, for example, to study the effects of test compounds as modulators, e.g., inhibitors, agonists and antagonists, of protein activity.

Abstract: The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.

Abstract: The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage constructs and methods for their use to permit phage coat protein expression, and thus phage propagation, in the absence of display of heterologous polypeptides, which may be expressed as a fusion with said coat protein in a regulated manner.

Abstract: The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage constructs and methods for their use to permit phage coat protein expression, and thus phage propagation, in the absence of display of heterologous polypeptides, which may be expressed as a fusion with said coat protein in a regulated manner.

Abstract: A pallet having first and second decks with at least two post assemblies extending between the first and second decks to maintain the first and second decks at a distance from one another. Each post assembly includes an outer post member including a substantially hollow body extending axially from a base connected to the first deck to a free end and an inner post member including a body extending axially from a base connected to the second deck to a free end. The inner post body free end is configured to be received in the outer post body with the inner and outer posts positioned relative to one another such that at least one of the post free ends contacts the respective opposed deck and supports the first and second decks in spaced relationship.

Abstract: A memory controller includes a plurality of channel control circuits. Each of the plurality of channel control circuits is coupled to a respective one of a plurality of channels which are coupled to a memory system. The plurality of channel control circuits are coupled to receive an indication of whether or not the plurality of channels are ganged. Data is transferred for a first command on each of the plurality of channels responsive to the indication indicating that the plurality of channels are ganged. Responsive to the indication indicating that the plurality of channels are not ganged, data is transferred for the first command on a selected channel of the plurality of channels. In some embodiments, the memory controller may be integrated with one or more processors.