Patents by Inventor Daniel Kerkman

Daniel Kerkman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Predicting Whether Subjects With Mild Cognitive Impairment (MCI) Will Develop Alzheimer's Disease
    Publication number: 20090022825
    Abstract: The invention provides methods of diagnosing mild cognitive impairment (MCI) in a patient and methods of predicting cognitive decline in patients who have MCI. The invention also provides methods for predicting if a patient who has MCI will develop Alzheimer's Disease (AD).
    Type: Application
    Filed: May 2, 2008
    Publication date: January 22, 2009
    Inventors: Daniel Kerkman, John F. DeBernardis, Raymond Zinkowski, Harald Juergen Hampel
  • Certain substituted 1-aryl-3-piperazine-1?-yl propanones
    Patent number: 7173132
    Abstract: Disclosed are compounds of formula I: wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydrogen; or Y and R1 or R2 together represent CH2; CH2CH2; CH2O; CH2S forming a five or six membered ring and such ring may be optionally substituted with loweralkyl or phenyl; or the pharmaceutically acceptable salts thereof, useful in the treatment of neoplastic diseases, and bacterial or fungal infections, and in preventing or decreasing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore, useful for treating Alzheimer's Disease.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: February 6, 2007
    Assignee: Molecular Geriatrics Corporation
    Inventors: John DeBernardis, Daniel Kerkman, Raymond Zinkowski
  • Purified antigen for Alzheimer's disease and methods of obtaining and using same
    Publication number: 20050272094
    Abstract: The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detectiing human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.
    Type: Application
    Filed: March 8, 2005
    Publication date: December 8, 2005
    Inventors: Raymond Zinkowski, Daniel Kerkman, Russell Kohnken, John DeBernardis, Peter Davies
  • Method for predicting whether subjects with mild cognitive impairment (MCI) will develop Alzheimer's Disease
    Publication number: 20040166536
    Abstract: The invention provides methods of diagnosing mild cognitive impairment (MCI) in a patient and methods of predicting cognitive decline in patients who have MCI. The invention also provides methods for predicting if a patient who has MCI will develop Alzheimer's Disease (AD).
    Type: Application
    Filed: November 7, 2003
    Publication date: August 26, 2004
    Applicant: Molecular Geriatrics Corporation
    Inventors: Daniel Kerkman, John F. DeBernardis, Raymond Zinkowski, Harald Juergen Hampel
  • Certain substituted 1-aryl-3-piperazine-1'-yl propanones
    Publication number: 20010025105
    Abstract: Disclosed are compounds of formula I: 1
    Type: Application
    Filed: April 9, 2001
    Publication date: September 27, 2001
    Applicant: Molecular Geriatarics Corporation
    Inventors: John DeBernardis, Daniel Kerkman, Raymond Zinkowski