Abstract: A transport system for delivery or retrieval of a biostimulator, such as a leadless cardiac pacemaker, is described. The biostimulator transport system includes a docking cap supported by a bearing within a bearing housing. The bearing allows relative rotation between a torque shaft connected to the docking cap and an outer catheter connected to the bearing housing. The bearing housing and the docking cap include respective bearing retainers that constrain the bearing within the bearing housing without a weld attachment. The weldless retainers of the biostimulator transport system provide a robust mechanical securement of the bearing that is not vulnerable to corrosion. Other embodiments are also described and claimed.

Abstract: The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators.

Abstract: The use of tocotrienols in medicine, veterinary or cosmetics, namely through the stabilization of tocotrienols, in particular in cosmetic formulations without hampering its functions in the skin is provided. In particular, the modification of tocotrienols with nicotinic acid results in the stabilization of the molecule and the penetration profile in human skin. The compounds and composition of are useful in medicine, veterinary or cosmetic industry namely in the prevention, therapy or treatment of skin diseases, skin disorders, or as a therapy or treatment of acne, seborrheic dermatitis or as an anti-aging agent.

Abstract: The use of tocotrienols in medicine, veterinary or cosmetics, namely through the stabilization of tocotrienols, in particular in cosmetic formulations without hampering its functions in the skin is provided. In particular, the modification of tocotrienols with nicotinic acid results in the stabilization of the molecule and the penetration profile in human skin. The compounds and composition of are useful in medicine, veterinary or cosmetic industry namely in the prevention, therapy or treatment of skin diseases, skin disorders, or as a therapy or treatment of acne, seborrheic dermatitis or as an anti-aging agent.

Abstract: A motorized bicycle training wheel system for training people to ride a bike without pedaling includes a pair of motorized training wheels each comprising an attachment bracket, a motor, and a wheel. The attachment bracket has an attachment aperture to receive an axle of a bicycle. The motor has a motor housing coupled to a lower portion of the attachment bracket. The wheel is coupled to a drive shaft of the motor. A battery is in operational communication with the motor of each of the pair of motorized training wheels and coupled to a frame of the bicycle. A throttle is in operational communication with the battery and the motor of each of the pair of motorized training wheels and coupled to a handlebar of the bicycle.

Abstract: A motorized bicycle training wheel system for training people to ride a bike without pedaling includes a pair of motorized training wheels each comprising an attachment bracket, a motor, and a wheel. The attachment bracket has an attachment aperture to receive an axle of a bicycle. The motor has a motor housing coupled to a lower portion of the attachment bracket. The wheel is coupled to a drive shaft of the motor. A battery is in operational communication with the motor of each of the pair of motorized training wheels and coupled to a frame of the bicycle. A throttle is in operational communication with the battery and the motor of each of the pair of motorized training wheels and coupled to a handlebar of the bicycle.

Abstract: Generating, modeling, and operating optimal scorecards for credit risk evaluations is provided to a financial institution. Customer data is aggregated from a set of customer accounts. A score is generated for each product offered by a financial institution, where each score contributes to a plurality of combinations of scores. An aggregated model is generated based on the aggregated customer data and the generated scores. An aggregated score is computed using the aggregated model. In aspects of the subject innovation, the systems and methods disclosed leverage data from several sources and to include internal competitive and external competitive data to provide a more focused view of the consumer.

Abstract: The innovation disclosed and claimed herein, in one aspect thereof, comprises systems and methods of managing regulatory questions. The systems and methods receive a question having words and phrases. The systems and methods identify keywords in the question using a knowledgebase. The systems and methods determine closely related questions based on the identification, the closely related questions having answers associated with each question of the closely related questions. The systems and methods perform machine learning on the answers of the determined closely related questions.

Abstract: In accordance with embodiments of the herein disclosed subject matter it is described a stirring device (100) comprising a shaft rotatable about an axis of rotation; a stirring element (106) attached to the shaft, the stirring element (106) having a recess (108); the recess (108) having a surface portion (114) and an edge (116), the edge (116) defining an opening which provides access to the surface portion (114); the recess (108) being spaced from the shaft, wherein a rotation of the shaft defines a moving direction (120) of the recess (108) in which the edge (116) forms a leading edge of the recess (108); the surface portion (114) defining a depth (122) of the recess (108) with regard to the edge (116); and wherein in a direction (124) radially inwardly the depth (122) of the recess (108) is decreasing.

Abstract: A modular system in the form of a load-bearing frame to be arranged in a tail region of a motor vehicle. The modular components which are to be linked or are linked include at least one cast structure and at least two profiles, the cast structure comprising at least one node.

Abstract: In accordance with embodiments of the herein disclosed subject matter it is described a stirring device (100) comprising a shaft rotatable about an axis of rotation; a stirring element (106) attached to the shaft, the stirring element (106) having a recess (108);the recess (108) having a surface portion (114) and an edge (116), the edge (116) defining an opening which provides access to the surface portion (114); the recess (108) being spaced from the shaft, wherein a rotation of the shaft defines a moving direction (120) of the recess (108) in which the edge (116) forms a leading edge of the recess (108); the surface portion (114) defining a depth (122) of the recess (108) with regard to the edge (116); and wherein in a direction (124) radially inwardly the depth (122) of the recess (108) is decreasing.

Abstract: A modular system in the form of a load-bearing frame to be arranged in a tail region of a motor vehicle. The modular components which are to be linked or are linked include at least one cast structure and at least two profiles, the cast structure comprising at least one node.