Patents by Inventor Daniel Knappe
Daniel Knappe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10435437Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.Type: GrantFiled: December 23, 2016Date of Patent: October 8, 2019Assignee: UNIVERSITAET LEIPZIGInventors: Ralf Hoffmann, Daniel Knappe, Kai Hilpert, Ralf Mikut, Serge Ruden
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Publication number: 20170114096Abstract: The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12- P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group or a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative: L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13 and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17 and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged. Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus.Type: ApplicationFiled: August 4, 2016Publication date: April 27, 2017Inventors: Ralf Hoffmann, Daniel Knappe, Anne Klara Brigitte Thielbeer
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Publication number: 20170107256Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.Type: ApplicationFiled: December 23, 2016Publication date: April 20, 2017Inventors: Ralf Hoffmann, Daniel Knappe, Kai Hilpert, Ralf Mikut, Serge Ruden
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Patent number: 9556228Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to compositions and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.Type: GrantFiled: September 21, 2012Date of Patent: January 31, 2017Assignee: UNIVERSITAET LEIPZIGInventors: Ralf Hoffmann, Daniel Knappe, Kai Hilpert, Ralf Mikut, Serge Ruden
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Publication number: 20150344524Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to compositions and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.Type: ApplicationFiled: September 21, 2012Publication date: December 3, 2015Inventors: Ralf Hoffmann, Daniel Knappe, Kai Hilpert, Ralf Mikut, Serge Ruden
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Publication number: 20150299256Abstract: The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12- P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group pr a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative; L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13, and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17, and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged, Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus.Type: ApplicationFiled: February 25, 2014Publication date: October 22, 2015Applicant: AMP-THERAPEUTICS GMBHInventors: Ralf Hoffmann, Daniel Knapp, Anna Klara Brigitte Hansen
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Patent number: 8937155Abstract: The present invention relates to a antimicrobial peptide or peptide derivative comprising the following sequence: Sub1-X1-D2-K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-T16-P17-N18-N19-X4-Sub2. The invention further relates to multimers comprising said peptides or peptide derivatives. Moreover, the invention provides a peptide or peptide derivative for use in the treatment of a disease. The peptide or peptide derivative may also be used in the screening for novel antimicrobial compounds.Type: GrantFiled: May 27, 2011Date of Patent: January 20, 2015Assignee: AMP Therapeutics GmbHInventors: Ralf Hoffmann, Daniel Knappe
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Patent number: 8686113Abstract: The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group or a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative; L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13, and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17, and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged, Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus.Type: GrantFiled: January 29, 2010Date of Patent: April 1, 2014Assignee: AMP-Therapeutics GmbHInventors: Ralf Hoffmann, Daniel Knappe, Anna Klara Brigitte Hansen
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Publication number: 20130130994Abstract: The present invention relates to a antimicrobial peptide or peptide derivative comprising the following sequence: Sub1-X1-D2-K3—P4—P5—Y6-L7-P8—R9—P10X2—P12—P13—R14—X3-T16-P17—N18—N19-X4-Sub2. The invention further relates to multimers comprising said peptides or peptide derivatives. Moreover, the invention provides a peptide or peptide derivative for use in the treatment of a disease. The peptide or peptide derivative may also be used in the screening for novel antimicrobial compounds.Type: ApplicationFiled: May 27, 2011Publication date: May 23, 2013Applicant: AMP THERAPEUTICS GMBHInventors: Ralf Hoffmann, Daniel Knappe
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Publication number: 20120021975Abstract: The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group or a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative; L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13, and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17, and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged, Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus.Type: ApplicationFiled: January 29, 2010Publication date: January 26, 2012Inventors: Ralf Hoffmann, Daniel Knappe, Anna Klara Brigitte Hansen
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Publication number: 20080087811Abstract: Embodiments of the invention include methods and devices for the analysis of proteins utilizing a gold coated nanoporous alumina surface for dual ionization mode mass spectrometric analysis using desorption electrospray ionization (DESI) and laser desorption ionization (LDI). Combined use of DESI and LDI gives increased sequence coverage in peptide mixture analysis from a single sample preparation.Type: ApplicationFiled: September 20, 2007Publication date: April 17, 2008Inventor: Daniel Knapp
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Patent number: 6795632Abstract: A method and system of managing slack in fiber optic cables connected to a circuit board is provided. A fiber optic cable is supported at a point between and not colinear with the two points to which it is attached to the circuit board. The fiber optic cables are preferably supported a vertical distance above the circuit board each with a plurality of points of support on a radius guide, preferably two radius guides. The radius guides each have a leading edge and a trailing edge for supporting the cable and a curved central portion therebetween around which the cable is bent. The cables are preferably tensioned between at least two of the points of support so that cables of differing lengths are taut to prevent movement during shipping or to prevent vibration that would otherwise be caused by air flow over the circuit board.Type: GrantFiled: November 2, 2001Date of Patent: September 21, 2004Assignee: Ciena CorporationInventors: Daniel Knapp, James Casciani