Abstract: Provided are high-throughput screens for biologically active modulators of a target enzyme that mimic or recreate natural processes of diversification and selection. In some embodiments, the platform comprises one or more expression systems including without limitation (i) a two-hybrid system that, when expressed in a cell, links survival of the cell to the modulation of a therapeutic target, and (ii) a metabolic system that enables the biosynthesis of structurally varied modulators of the therapeutic agent.

Abstract: Methods and apparatuses related to federated search of multiple sources with conflict resolution are disclosed. A method may comprise obtaining a set of data ontologies (e.g., types, properties, and links) associated with a plurality of heterogeneous data sources; receiving a selection of a graph comprising a plurality of graph nodes connected by one or more graph edges; and transforming the graph into one or more search queries across the plurality of heterogeneous data sources. A method may comprise obtaining a first data object as a result of executing a first search query across a plurality of heterogeneous data sources; resolving, based on one or more resolution rules, at least the first data object with a repository data object; deduplicating data associated with at least the first data object and the repository data object prior to storing the deduplicated data in a repository that has a particular data model.

Abstract: Systems and methods including a framework for migration of live data. The method may comprised, by one or more hardware processors executing program instructions, receiving, at a migration proxy of the framework, code for reading data and writing data compatible with each of a plurality of states of a migration of data in a data store, wherein a service is at least intermittently reading data from and writing data to the data store; determining, by a migration runner of the framework, to perform the migration of the data; initiating, by the migration runner, the migration of the data, wherein the migration comprises a plurality of stages; storing, as the migration progresses through the plurality of stages, and at a migration data store of the framework, a current stage of the migration; and during the migration, using the migration proxy to read data from and write data to the data store.

Abstract: Systems and methods including a framework for migration of live data. The method may comprised, by one or more hardware processors executing program instructions, receiving, at a migration proxy of the framework, code for reading data and writing data compatible with each of a plurality of states of a migration of data in a data store, wherein a service is at least intermittently reading data from and writing data to the data store; determining, by a migration runner of the framework, to perform the migration of the data; initiating, by the migration runner, the migration of the data, wherein the migration comprises a plurality of stages; storing, as the migration progresses through the plurality of stages, and at a migration data store of the framework, a current stage of the migration; and during the migration, using the migration proxy to read data from and write data to the data store.

Abstract: The invention relates to an anode circuit (8) for a fuel cell (3) having at least one gas jet pump (6) for recirculating anode exhaust gas, which has at least one nozzle (18) through which the fuel gas (H 2) may flow as a fuel gas flow, and which has a fuel gas line (14), a recirculation line (7), and an outflow line (15). The anode circuit according to the invention is characterized in that a plurality of nozzles (18) with different geometries are arranged in a nozzle body (16), which is movable relative to the fuel gas line (14) in such a manner that in each case one of the nozzles (18) is selectively usable.

Abstract: Systems and methods including a framework for migration of live data. The method may comprised, by one or more hardware processors executing program instructions, receiving, at a migration proxy of the framework, code for reading data and writing data compatible with each of a plurality of states of a migration of data in a data store, wherein a service is at least intermittently reading data from and writing data to the data store; determining, by a migration runner of the framework, to perform the migration of the data; initiating, by the migration runner, the migration of the data, wherein the migration comprises a plurality of stages; storing, as the migration progresses through the plurality of stages, and at a migration data store of the framework, a current stage of the migration; and during the migration, using the migration proxy to read data from and write data to the data store.

Abstract: Methods and apparatuses related to federated search of multiple sources with conflict resolution are disclosed. A method may comprise obtaining a set of data ontologies (e.g., types, properties, and links) associated with a plurality of heterogeneous data sources; receiving a selection of a graph comprising a plurality of graph nodes connected by one or more graph edges; and transforming the graph into one or more search queries across the plurality of heterogeneous data sources. A method may comprise obtaining a first data object as a result of executing a first search query across a plurality of heterogeneous data sources; resolving, based on one or more resolution rules, at least the first data object with a repository data object; deduplicating data associated with at least the first data object and the repository data object prior to storing the deduplicated data in a repository that has a particular data model.

Abstract: The invention relates to a cooking oven comprising at least two entities made of sheet metal (2, 3), each sheet metal entity (2, 3) comprising at least one surface carrying an enamel layer, specifically a vitreous enamel layer, said enamelled sheet metal entities (2, 3) overlapping each other and a screw connection for grounding and coupling said enamelled sheet metal entities (2, 3), wherein a ground element is at least indirectly coupled with one of said enamelled sheet metal entities (2, 3) for grounding said stack of enamelled sheet metal entities (2, 3), wherein at least one screw (5) with a screw shaft (5.1) is provided through said enamelled sheet metal entities (2, 3), wherein the screw (5) is at least indirectly electrically coupled with the ground element and said screw shaft (5.1) comprises a thread for providing an electric coupling between the enamelled sheet metal entities (2, 3).

Abstract: A non-metallic gasket for flanged connections that is capable of achieving the necessary gasket stress to maintain a leak-free seal between the two flanges especially in applications when metallic gaskets cannot be used. The gasket may utilize glass reinforced epoxy, or rigid non-metallic material, as the gasket core. The core receives a kammprofile set of serrations machined into both faces. On top of the serrations a sealing element of varying material is adhered.

Abstract: A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.

Abstract: In a washing element holder (2), which on one side is closed off relative to the outside (s) with a sponge material (5) having pores (4), a washing device (1) has a washing element (3) which has at least one synthetic surfactant as a foaming substance and the principal constituent.

Abstract: The invention relates to a cooking oven comprising at least two entities made of sheet metal (2, 3), each sheet metal entity (2, 3) comprising at least one surface carrying an enamel layer, specifically a vitreous enamel layer, said enamelled sheet metal entities (2, 3) overlapping each other and a screw connection for grounding and coupling said enamelled sheet metal entities (2, 3), wherein a ground element is at least indirectly coupled with one of said enamelled sheet metal entities (2, 3) for grounding said stack of enamelled sheet metal entities (2, 3), wherein at least one screw (5) with a screw shaft (5.1) is provided through said enamelled sheet metal entities (2, 3), wherein the screw (5) is at least indirectly electrically coupled with the ground element and said screw shaft (5.1) comprises a thread for providing an electric coupling between the enamelled sheet metal entities (2, 3).

Abstract: Methods and apparatuses related to federated search of multiple sources with conflict resolution are disclosed. A method may comprise obtaining a set of data ontologies (e.g., types, properties, and links) associated with a plurality of heterogeneous data sources; receiving a selection of a graph comprising a plurality of graph nodes connected by one or more graph edges; and transforming the graph into one or more search queries across the plurality of heterogeneous data sources. A method may comprise obtaining a first data object as a result of executing a first search query across a plurality of heterogeneous data sources; resolving, based on one or more resolution rules, at least the first data object with a repository data object; deduplicating data associated with at least the first data object and the repository data object prior to storing the deduplicated data in a repository that has a particular data model.

Abstract: The present invention relates to a method for protecting a user of a light system (100), which comprises multiple illuminants (L1-L6), at least one light sensor (30) and at least one coding unit (40), from dazzling light from at least one of the illuminants (L1-L6), comprising the following steps: creating of a respective coding for light (M1-M6) of the individual illuminants (L1-L6) by the at least one coding unit (40), detecting of dazzling light (M2X) from at least one of the illuminants (L1-L6) by the at least one light sensor (30), assigning of the detected dazzling light (M2X) with the at least one associated illuminant (L2) on the basis of the coding of the light for the corresponding illuminant (L2), and setting of the at least one associated illuminant (L2) to protect the user from the detected dazzling light (M2X). The invention furthermore relates to a light system (100) and a machine (200) having the light system (100) for carrying out a method according to the invention.

Abstract: In a washing element holder (2), which on one side is closed off relative to the outside (s) with a sponge material (5) having pores (4), a washing device (1) has a washing element (3) which has at least one synthetic surfactant as a foaming substance and the principal constituent.

Abstract: In a washing element holder (2), which on one side is closed off relative to the outside(s) with a sponge material (5) having pores (4), a washing device (1) has a washing element (3) which has at least one synthetic surfactant as a foaming substance and the principal constituent.

Abstract: The present invention relates to a method for protecting a user of a light system (100), which comprises multiple illuminants (L1-L6), at least one light sensor (30) and at least one coding unit (40), from dazzling light from at least one of the illuminants (L1-L6), comprising the following steps: creating of a respective coding for light (M1-M6) of the individual illuminants (L1-L6) by the at least one coding unit (40), detecting of dazzling light (M2X) from at least one of the illuminants (L1-L6) by the at least one light sensor (30), assigning of the detected dazzling light (M2X) with the at least one associated illuminant (L2) on the basis of the coding of the light for the corresponding illuminant (L2), and setting of the at least one associated illuminant (L2) to protect the user from the detected dazzling light (M2X). The invention furthermore relates to a light system (100) and a machine (200) having the light system (100) for carrying out a method according to the invention.

Abstract: The invention relates to a screw connection comprising a structural element (2) comprising a screw hole (2.1) and a metal sheet (3) comprising a through hole (3.1), the structural element (2) and the metal sheet (3) being adapted to be connected by means of a screw (4) by screwing the screw (4) through the through hole (3.1) of the metal sheet (3) into the screw hole (2.1) of the structural element (2), wherein the metal sheet (3) comprises an embossment (5), said embossment (5) at least partially surrounding the through hole (3.1) in order to increase the distance (d) between an upper surface of the metal sheet (3) and the screw hole (2.1) provided in the structural element (2).

Abstract: A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.

Abstract: A network system uses the capabilities of client devices to search for objects in an image within a geographic region. The network system receives a request to search for an object and a geographic region within which to search the object. The network system provides instructions to client devices within the geographic region to search for the object. Upon receiving instructions to search for the object, the client device captures visual data of the area around the client device. The client device analyzes the visual data to detect the object and notifies the network system if the object is detected.