Patents by Inventor Daniel KULKE
Daniel KULKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230174492Abstract: The present invention relates to novel anthelmintic compounds of general formula (I): T-L-A ??(I) wherein A is A1 or A2 #2 indicates the binding position between the group L and A, T is a group T1-T6, L is a group L1-L10, and R1, R2, R3, R4, R5, R6 and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 8, 2021Publication date: June 8, 2023Inventors: Nils GRIEBENOW, Daniel KULKE, Iring HEISLER, Wei ZHUANG
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Publication number: 20230141809Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: December 9, 2022Publication date: May 11, 2023Inventors: Walter HUEBSCH, Nils GRIEBENOW, Hans-Georg SCHWARZ, Daniel KULKE, Claudia BOEHM, Kirsten BOERNGEN, Bernd ALIG, Wei ZHUANG, Iring HEISLER, Thomas ILG, Johannes KOEBBERLING, Adeline KOEHLER, Niels LINDNER, Ulrich GOERGENS, Claudia WELZ, Maike HINK
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Patent number: 11572357Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: May 7, 2019Date of Patent: February 7, 2023Assignee: Bayer Animal Health GmbHInventors: Walter Hübsch, Nils Griebenow, Hans-Georg Schwarz, Daniel Kulke, Claudia Böhm, Kirsten Börngen, Bernd Alig, Wei Zhuang, Iring Heisler, Thomas Ilg, Johannes Köbberling, Adeline Köhler, Niels Lindner, Ulrich Görgens, Claudia Welz, Maike Hink
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Patent number: 11505545Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: October 30, 2020Date of Patent: November 22, 2022Assignee: Bayer Animal Health GmbHInventors: Walter Hübsch, Johannes Köbberling, Adeline Köhler, Hans-Georg Schwarz, Daniel Kulke, Claudia Welz, Thomas Ilg, Kirsten Börngen, Wei Zhuang, Nils Griebnow, Claudia Böhm, Niels Lindner, Maike Hink, Ulrich Görgens
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Patent number: 11485733Abstract: The present invention covers azaquinoline compounds of general formula (I), with A being (A1) or (A2), and in which T, R1, R2, R3, R4, R5, R6 and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: June 22, 2018Date of Patent: November 1, 2022Assignee: BAYER ANIMAL HEALTH GMBHInventors: Nils Griebenow, Wei Zhuang, Adeline Köhler, Daniel Kulke, Claudia Böhm, Kirsten Börngen, Thomas Ilg, Hans-Georg Schwarz, Werner Hallenbach, Ulrich Görgens, Walter Hübsch, Bernd Alig, Iring Heisler, Isa Jana Irina Janssen
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Publication number: 20220274971Abstract: The present invention covers new isoquinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: July 27, 2020Publication date: September 1, 2022Inventors: Bernd ALIG, Walter HUEBSCH, Nils GRIEBENOW, Hans-Georg SCHWARZ, Wei ZHUANG, Daniel KULKE, Claudia BOEHM, Iring HEISLER, Isa Jana Irina JANSSEN, Kirsten BOERNGEN
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Patent number: 11364234Abstract: The present application relates to the treatment of nematode infections.Type: GrantFiled: September 10, 2019Date of Patent: June 21, 2022Assignees: The Governing Council of the University of Toronto, Ontario Institute for Cancer Research (OICR)Inventors: Peter Roy, Sean Harrington, Jacob Pyche, Daniel Kulke, Genna M. Luciani, Andrew Burns, Mark Lautens, Rachel Ross, David Uehling
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Publication number: 20220133688Abstract: The present invention relates to a milbemycin for use in control, treatment and/or prevention of infections with nematodes, preferably filariae, more preferably Dirofilaria immitis which are resistant to at least one other macrocyclic lactone anthelmintic. The present invention further relates to the use of milbemycins for stimulating attachment of polymorphonuclear neutrophils (PMNs) and/or peripheral blood mononuclear cells (PBMCs) to larvae of nematodes, as well as to a method for stimulating attachment of PMNs and/or PBMCs to larvae of nematodes. In a further aspect, the present invention relates to an in vitro assay for determining and/or characterizing an agent for control, treatment and/or prevention of an infection with nematodes.Type: ApplicationFiled: February 28, 2020Publication date: May 5, 2022Inventors: Daniel KULKE, Adrian WOLSTENHOLME, Barbara REAVES
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Patent number: 11254661Abstract: The present invention covers quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: July 30, 2018Date of Patent: February 22, 2022Inventors: Nils Griebenow, Wei Zhuang, Daniel Kulke, Claudia Böhm, Hans-Georg Schwarz, Walter Hübsch, Thomas Ilg
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Publication number: 20210380566Abstract: The present invention relates to novel compounds of general formula (I): with A being A1 or A2: and in which T, X, Y, Ro, R1, R10 and R11 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: October 23, 2019Publication date: December 9, 2021Inventors: Nils GRIEBENOW, Walter HUEBSCH, Hans-Georg SCHWARZ, Wei ZHUANG, Bernd ALIG, Adeline KEHLER, Daniel KULKE, Iring HEISLER, Thomas ILG
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Patent number: 11130768Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: April 23, 2018Date of Patent: September 28, 2021Assignee: Bayer Animal Health GmbHInventors: Nils Griebenow, Wei Zhuang, Daniel Kulke, Adeline Köhler, Thomas Ilg, Claudia Welz, Hans-Georg Schwarz, Ulrich Görgens, Walter Hübsch, Johannes Köbberling
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Publication number: 20210139468Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: May 7, 2019Publication date: May 13, 2021Inventors: Walter HÜBSCH, Nils GRIEBENOW, Hans-Georg SCHWARZ, Daniel KULKE, Claudia BÖHM, Kirsten BÖRNGEN, Bernd ALIG, Wei ZHUANG, Iring HEISLER, Thomas ILG, Johannes KÖBBERLING, Adeline KÖHLER, Niels LINDNER, Ulrich GÖRGENS, Claudia WELZ, Maike HINK
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Publication number: 20210115026Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: October 30, 2020Publication date: April 22, 2021Inventors: Walter HÜBSCH, Johannes KÖBBERLING, Adeline KÖHLER, Hans-Georg SCHWARZ, Daniel KULKE, Claudia WELZ, Thomas ILG, Kirsten BÖRNGEN, Wei ZHUANG, Nils GRIEBNOW, Claudia BÖHM, Niels LINDNER, Maike HINK, Ulrich GÖRGENS
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Patent number: 10934301Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I): in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: January 29, 2020Date of Patent: March 2, 2021Assignee: BAYER ANIMAL HEALTH GMBHInventors: Ulrich Görgens, Claudia Welz, Daniel Kulke, Claudia Böhm
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Patent number: 10889573Abstract: The present invention covers new quinoline compounds of general formula (I) in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: November 6, 2017Date of Patent: January 12, 2021Assignee: Bayer Animal Health GMBHInventors: Walter Hübsch, Johannes Köbberling, Adeline Köhler, Hans-Georg Schwarz, Daniel Kulke, Claudia Welz, Thomas Ilg, Kirsten Börngen, Wei Zhuang, Nils Griebenow, Claudia Böhm, Niels Lindner, Maike Hink, Ulrich Görgens
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Publication number: 20200377486Abstract: The present invention covers quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: July 30, 2018Publication date: December 3, 2020Applicant: Bayer Animal Health GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Daniel KULKE, Claudia BÖHM, Hans-Georg SCHWARZ, Walter HÜBSCH, Thomas ILG
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Publication number: 20200239482Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I): in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: January 29, 2020Publication date: July 30, 2020Applicant: BAYER ANIMAL HEALTH GMBHInventors: Ulrich GÖRGENS, Claudia WELZ, Daniel KULKE, Claudia BÖHM
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Publication number: 20200190111Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 23, 2018Publication date: June 18, 2020Applicant: Bayer Animal Health GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Daniel KULKE, Adeline KÖHLER, Thomas ILG, Claudia WELZ, Hans-Georg SCHWARZ, Ulrich GÖRGENS, Walter HÜBSCH, Johannes KÖBBERLING
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Publication number: 20200131175Abstract: The present invention covers azaquinoline compounds of general formula (I), with A being (A1) or (A2), and in which T, R1, R2, R3, R4, R5, R6 and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: June 22, 2018Publication date: April 30, 2020Applicant: BAYER ANIMAL HEALTH GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Adeline KÖHLER, Daniel KULKE, Claudia BÖHM, Kirsten BÖRNGEN, Thomas ILG, Hans-Georg SCHWARZ, Werner HALLENBACH, Ulrich GÖRGENS, Walter HÜBSCH, Bernd ALIG, Iring HEISLER, Isa Jana Irina JANSSEN
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Patent number: 10604525Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: April 10, 2017Date of Patent: March 31, 2020Assignee: BAYAL ANIMAL HEALTH GMBHInventors: Adeline Köhler, Claudia Welz, Kirsten Börngen, Daniel Kulke, Thomas Ilg, Johannes Köbberling, Walter Hübsch, Hans-Georg Schwarz, Ulrich Görgens, Ulrich Ebbinghaus-Kintscher, Maike Hink, Dirk Nennstiel, Klaus Raming, Martin Adamczewski, Claudia Böhm, Nils Griebenow, Wei Zhuang