Abstract: The present invention generally relates to immunogenic compositions comprising pan-coronavirus antigenic polypeptides and antibodies, and methods of use thereof for the treatment and prevention of coronavirus infection.

Abstract: Disclosed herein are nucleic acid encoded Fc-modified antibodies and methods of use of the same for the treatment of diseases and disorders.

Abstract: Disclosed herein are antibodies to SARS-COV-2 antigens and recombinant nucleic acid sequences that encode the SARS-COV-2 antibodies. The disclosure also provides a method of preventing and/or treating a SARS-COV-2 infection or disease or disorder associated with SARS-COV-2 infection (e.g., COVID-19) in a subject using said compositions and methods.

Abstract: Disclosed herein are glycan-coated RBD immunogens, engineered nanoparticle vaccines comprising glycan-coated RBD immunogens and methods of use thereof for SARS-COV-2 vaccines.

Abstract: Disclosed herein are nanoparticles comprising one or more Human papillomavirus (HPV) antigen and nucleic acid molecules encoding the same. Also disclosed herein is a method of treating a HPV infection or treating or preventing a disease or disorder associated therewith in a subject in need thereof, by administering the nanoparticles, or encoding nucleic acid molecules, to the subject.

Abstract: Disclosed herein are nanoparticles comprising one or more SARS coronavirus 2 (SARS-CoV-2) Spike receptor binding domain (RBD) antigen and nucleic acid molecules encoding the same. Also disclosed herein is a method of treating a SARS-COV-2 infection or treating or preventing a disease or disorder associated therewith in a subject in need thereof, by administering the nanoparticles, or encoding nucleic acid molecules, to the subject.

Abstract: The present invention provides compositions comprising cellular receptor mimics and methods for treating or preventing coronavirus infection or a disease or disorder associated with coronavirus infection such as COVID-19.

Abstract: The present invention relates to engineered outer domain (eOD) immunogens of HIV gp120 and mutants thereof and methods of making and using the same. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity. The mutant eODs bind to neutralizing antibody precursors. The mutant eODs can activate germline precursors on the pathway to eliciting a broadly neutralizing antibody (bnAb) response. The invention also relates to immunized knock-in mice expressing germline-reverted heavy chains. Induced antibodies showed characteristics of bnAbs and mutations that favored binding to near-native HIV-1 gp120 constructs. In contrast, native-like immunogens failed to activate precursors. The invention also relates to rational epitope design that can prime rare B cell precursors for affinity maturation to desired targets.

Abstract: The present invention relates to engineered outer domain (eOD) immunogens of HIV gp120 and mutants thereof and methods of making and using the same. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity. The mutant eODs bind to neutralizing antibody precursors. The mutant eODs can activate germline precursors on the pathway to eliciting a broadly neutralizing antibody (bnAb) response. The invention also relates to immunized knock-in mice expressing germline-reverted heavy chains. Induced antibodies showed characteristics of bnAbs and mutations that favored binding to near-native HIV-1 gp120 constructs. In contrast, native-like immunogens failed to activate precursors. The invention also relates to rational epitope design that can prime rare B cell precursors for affinity maturation to desired targets.

Abstract: A protective footwear article is provided that has a sole, a shoe upper, and a removable toe cover affixable over the toe box of the footwear article. The forward toe region of the sole includes a leading edge having a recess therealong, while a channel extends laterally across the sole and terminates along the sides thereof. Removably positioned over the toe box of the footwear article is a removable toe cover that has a hardened structure to protect the toes of the wearer. The toe cover further comprises a connecting tab that engages the recess in the sole, and is affixed along the sides of the sole via a securing rod that extends through the toe over and through the channel in the sole. The securing rod is removably secured through the toe cover and the sole after the connecting tab is positioned within the forward recess of the sole.