Abstract: The disclosure provides compositions, methods, and devices for use in delivering Mitomycin-C(MMC), an antineoplastic chemotherapy drug often used for bladder instillations to treat bladder cancer, which degrades in both acidic and alkaline environments. The disclosure provides a solution of buffered MMC (or a different drug) in 50% propylene glycol that maintains a pH from 7.0 to 8.0 when introduced into acidic solutions (pH of 5.0) and is stable when stored at 2-8° C. for greater than 134 days. This formulation can be produced in an FDA registered 503B Outsourcing facility in a pre-filled, ready-to-administer syringe kit with pre-attached closed system transfer device and accessories required for bladder instillation.

Abstract: Methods are disclosed for making a band-driven package or a band-drive component for a package, and machines for performing the methods. One method comprises feeding first and second flexible webs in a feed direction, one web being fed each side of a substrate such that the webs are in mutual face-to-face disposition ahead of and behind the substrate with respect to the feed direction; joining the face-to-face webs at a first join ahead of the substrate and at a second join behind the substrate, the joins bounding web portions that together encircle the substrate between the joins; and dividing the joined web portions from the remainder of the webs such that the joined web portions together define a band that encircles the substrate, to be slid around the substrate in use of the package.

Abstract: Methods are disclosed for making a band-driven package or a band-drive component for a package, and machines for performing the methods. One method comprises feeding first and second flexible webs in a feed direction, one web being fed each side of a substrate such that the webs are in mutual face-to-face disposition ahead of and behind the substrate with respect to the feed direction; joining the face-to-face webs at a first join ahead of the substrate and at a second join behind the substrate, the joins bounding web portions that together encircle the substrate between the joins; and dividing the joined web portions from the remainder of the webs such that the joined web portions together define a band that encircles the substrate, to be slid around the substrate in use of the package.

Abstract: Methods are disclosed for making a band-driven package or a band-drive component for a package, and machines for performing the methods. One method comprises feeding first and second flexible webs in a feed direction, one web being fed each side of a substrate such that the webs are in mutual face-to-face disposition ahead of and behind the substrate with respect to the feed direction; joining the face-to-face webs at a first join ahead of the substrate and at a second join behind the substrate, the joins bounding web portions that together encircle the substrate between the joins; and dividing the joined web portions from the remainder of the webs such that the joined web portions together define a band that encircles the substrate, to be slid around the substrate in use of the package.

Abstract: Methods are disclosed for making a band-driven package or a band-drive component for a package, and machines for performing the methods. One method comprises feeding first and second flexible webs in a feed direction, one web being fed each side of a substrate such that the webs are in mutual face-to-face disposition ahead of and behind the substrate with respect to the feed direction; joining the face-to-face webs at a first join ahead of the substrate and at a second join behind the substrate, the joins bounding web portions that together encircle the substrate between the joins; and dividing the joined web portions from the remainder of the webs such that the joined web portions together define a band that encircles the substrate, to be slid around the substrate in use of the package.