Abstract: A method for electronically tracking and verifying the application, removal, and chain of custody of wearable drug testing patches is provided. The method involves applying a drug testing patch to a wearer, electronically logging application events associated with the drug patch, including capturing electronic signatures from both the wearer and a first technician, and compiling an application chain of custody document for the respective drug patch that links client information, case record information, the patch serial number, and the respective electronic signature identifiers. After a predetermined wear duration, the drug patch is removed by a second technician, and a patch removal event is logged, including capturing electronic signatures from both the wearer and the second technician. A completed chain of custody document, including a barcode linked to the client, case record, and the patch is generated to allow a laboratory to upload results of an associated testing protocol.