Patents by Inventor Daniel Kuzmich

Daniel Kuzmich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease
    Patent number: 6414153
    Abstract: Novel compounds of the formula I: which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydro-indol-2-one; 3-benzyl-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-hydroxy-3-methyl-1,3-dihydroindol-2-one; and, 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-fluoro-1,3-dihydroindol-2-one.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: July 2, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Terence Alfred Kelly, Jiang-Ping Wu, Daniel Kuzmich, Yancey David Ward, Leah Lynn Frye
  • Small molecules useful in the treatment of inflammatory disease
    Patent number: 6365615
    Abstract: Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 2-(3,5-Dichlorophenyl)-7-(R*)-phenyl-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; 2-(3,5-Dichlorophenyl)-7a-(R*)-methyl-7-(R*)-phenyl-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; and, 7-(R*)-(4-Bromophenyl)-2-(3,5-dichlorophenyl)-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: April 2, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Terence Alfred Kelly, Jiang-Ping Wu, Daniel Kuzmich
  • Methods and compositions for controlling intraocular pressure with transition metal complexes
    Patent number: 5356932
    Abstract: Compositions and methods for controlling intraocular pressure using transition metal complexes are disclosed. Topical ophthalmic and systemic administration of the transition metal complexes is disclosed.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: October 18, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Hans R. Moll, Mark T. DuPriest, Daniel Kuzmich
  • Intermediates in the preparation of chiral spirofluorenehydantoins
    Patent number: 5151544
    Abstract: Disclosed is a process for the synthesis of enantiomerically pure R and S isomers of 2,7-difluoro-4-methoxyspiro[9H-fluorene-9,4-imidazolidene]-2',5'-dione from 2,7-difluoro-4-methoxyfluorenone. Intermediate amino acid esters and urea esters and their preparation are also described.
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: September 29, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark T. DuPriest, Raymond E. Conrow, Daniel Kuzmich