Abstract: Means for predicting overall survival (OS) and progression free survival (PFS) of subjects having cancer are disclosed, where the predictions are based on the number of CCR5 pools in circulating cells, such as circulating cancer associated macrophage-like cells (CAMLs) and circulating tumor cells (CTCs) found in a biological sample, such as blood, from the subject. CCR5 expression can also be used for companion or complementary diagnostics.

Abstract: The present invention provides for two types of wide operating temperature range electrolyte formulations that contain methyl butyrate (MB) and additives have been investigated and compared in Lithium-ion capacitors (LICs), which were consisted of hard carbon (HC)/stabilized lithium metal powder (SLMP) anodes and activated carbon (AC) cathodes. The electrolyte L1 that was 1M LiPF6 in ethylene carbonate (EC)+ethyl methyl carbonate (EMC)+MB (20:20:60 v/v %)+0.1M lithium bis(oxalato)borate (LiBOB) and electrolyte L2 that was 1M LiPF6 in EC+EMC+MB (20:20:60 v/v %)+0.1M lithium difluoro(oxalato)borate (LiDFOB) enabled the LICs to discharge at the temperature as low as ?40° C., which the conventional electrolyte LP30 that was 1 M LiPF6 in EC+dimethyl carbonate (DMC) (50:50 w/w %) could not achieve. At the low temperature of ?40° C., L2 held more than 64% of the discharge capacity at 30° C., while the L1 only had the discharge capacity retention of 30%.

Abstract: The present invention provides for two types of wide operating temperature range electrolyte formulations that contain methyl butyrate (MB) and additives have been investigated and compared in Lithium-ion capacitors (LICs), which were consisted of hard carbon (HC)/stabilized lithium metal powder (SLMP) anodes and activated carbon (AC) cathodes. The electrolyte L1 that was 1M LiPF6 in ethylene carbonate (EC)+ethyl methyl carbonate (EMC)+MB (20:20:60 v/v %)+0.1M lithium bis(oxalato)borate (LiBOB) and electrolyte L2 that was 1M LiPF6 in EC+EMC+MB (20:20:60 v/v %)+0.1M lithium difluoro(oxalato)borate (LiDFOB) enabled the LICs to discharge at the temperature as low as ?40° C., which the conventional electrolyte LP30 that was 1 M LiPF6 in EC+dimethyl carbonate (DMC) (50:50 w/w %) could not achieve. At the low temperature of ?40° C., L2 held more than 64% of the discharge capacity at 30° C., while the L1 only had the discharge capacity retention of 30%.

Abstract: Cytokeratin (CK)+/CD45?/DAPI+ cells in the blood of cancer patients have been considered by most as circulating tumor cells (CTCs). Different methods of isolating CTCs results in a wide range of numbers and subgroups of CTCs from same patient. As a result, the clinical significance of the number of CTCs becomes cloudy. Provided herein is methodology to categorize CTCs into morphologically distinct subpopulations, and to use one of the subpopulations in methods for predicting overall survival of a patient having cancer.

Abstract: A method of detecting target cells and pathogens in a test sample concentrates to target cells in solution by filtering or capturing the target cells on a solid support. The target cells are tagged with a fluorescent dye and dispersed in a solution or suspension. The resulting solution or suspension are introduced to a fluorometer to specifically identify and quantitate the target cells. The target cells can be lysed or whole when introduced to the fluorometer.

Abstract: A new configuration of a pressurized water reactor nuclear fuel assembly having a disengaging upper tie plate corner portion (60) which will disengage if the fuel assembly is unintentionally lifted, thus precluding the lifting of the fuel assembly from the reactor core and thereby avoiding the potential risk of dropping the irradiated nuclear fuel assembly.

Abstract: A lower tie plate for a nuclear fuel assembly is provided via an integral casting including a frame containing a first plurality of guide tube bosses in a central portion thereof, a second plurality of guide tube bosses concentric with the first plurality of guide tube bosses, and a plurality of teardrop shaped struts connecting the first and second guide tube bosses to one another and to the frame. The guide tube bosses serve to respectively directly receive individual guide tube cap screws of guide tubes of the nuclear fuel assembly. The interior top portion of the lower tie plate is configured to receive and support a debris screen.