Abstract: Semisolid topical pharmaceutical compositions comprising a therapeutically effective amount of a mammalian hormone and an effective amount of a penetration enhancer and methods for their use are provided. The pharmaceutical compositions and methods for their use can provide blood or plasma levels of the administered hormone within a predetermined or normal range of hormone values. In particular embodiments, the hormone is testosterone or estrogen and the amount to be applied to the skin of the subject is determined according to the weight or body mass index of the subject. The topical composition can be formulated in solutions, creams, lotions, ointments, and gels.

Abstract: The present invention provides methods for reducing pain associated with chronic anal fissures with reduced side effects, comprising: contacting an anal area with a composition comprising an effective amount of nitroglycerin, thereby relieving pain associated with anal fissures. It also provides a extremely stable pharmaceutical composition comprising nitroglycerin, propylene glycol, and a non-ionic surfactant, as well as kits.