Abstract: In various embodiments nanoparticle drug delivery vehicles are provided that specifically deliver a cargo to a target pathogenic organism. In certain embodiments the drug delivery vehicle comprises a mesoporous silica nanoparticle comprising a plurality of pores and an outer surface through which the pores are disposed; a cargo disposed in the pores; one or more antigens attached to the surface of the nanoparticle; an antibody that specifically binds the antigens and are bound to the antigens, wherein the antibody inhibits diffusion of the cargo out of the pores and permit release of the cargo when the drug delivery vehicle is in the presence of the antigen or a pathogen displaying the antigen.

Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

Abstract: In various embodiments nanoparticle drug delivery vehicles are provided that specifically deliver a cargo to a target pathogenic organism. In certain embodiments the drug delivery vehicle comprises a mesoporous silica nanoparticle comprising a plurality of pores and an outer surface through which the pores are disposed; a cargo disposed in the pores; one or more antigens attached to the surface of the nanoparticle; an antibody that specifically binds the antigens and are bound to the antigens, wherein the antibody inhibits diffusion of the cargo out of the pores and permit release of the cargo when the drug delivery vehicle is in the presence of the antigen or a pathogen displaying the antigen.

Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

Abstract: A nozzle adapter assembly is provided for adapting use of nozzles on liquid dispensing pumps with test and measurement equipment such as liquid provers, test measures and liquid proving systems. The adapter can be used with automatic shut-off nozzles through which the liquid may normally be dispensed.

Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

Abstract: A liquid proving system is provided with a small volume liquid prover draining into a liquid holding tank that has capacity for multiple proving measurements. The small volume liquid prover can either be top-filled or bottom-filled, or exclusively bottom-filled. A liquid holding tank baffle assembly contains saturated vapor from an initial number of fills of the liquid holding tank within the small volume prover to improve overall accuracy of the proving measurements. When liquid is pumped into the prover evaporation of the liquid being pumped into the prover, and release of vapors from the prover, is inhibited due to the saturated vapor environment established by a saturated vapor volume in the prover, which results in a more accurate prover measurement of liquid pumped into the prover.

Abstract: A liquid proving system is provided with a small volume liquid prover draining into a liquid holding tank that has capacity for multiple proving measurements. The small volume liquid prover is top-filled and bottom-drained. A liquid holding tank baffle assembly contains saturated vapor from an initial number of fills of the liquid holding tank within the small volume prover to improve overall accuracy of the proving measurements. When liquid is pumped into the prover evaporation of the liquid being pumped into the prover, and release of vapors from the prover and into the entire holding tank, is inhibited due to the saturated vapor environment established by a saturated vapor volume in the prover, which results in a more accurate prover measurement of liquid pumped into the prover.

Abstract: A liquid proving system is provided with a small volume liquid prover draining into a liquid holding tank that has capacity for multiple proving measurements. The small volume liquid prover can either be top-filled or bottom-filled, or exclusively bottom-filled. A liquid holding tank baffle assembly contains saturated vapor from an initial number of fills of the liquid holding tank within the small volume prover to improve overall accuracy of the proving measurements. When liquid is pumped into the prover evaporation of the liquid being pumped into the prover, and release of vapors from the prover, is inhibited due to the saturated vapor environment established by a saturated vapor volume in the prover, which results in a more accurate prover measurement of liquid pumped into the prover.

Abstract: A nozzle adapter assembly is provided for adapting use of nozzles on liquid dispensing pumps with test and measurement equipment such as liquid provers, test measures and liquid proving systems. The adopter can be used with automatic shut-off nozzles through which the liquid may normally be dispensed.

Abstract: A liquid proving system is provided with a small volume liquid prover draining into a liquid holding tank that has capacity for multiple proving measurements. The small volume liquid prover is top-filled and bottom-drained. A liquid holding tank baffle assembly contains saturated vapor from an initial number of fills of the liquid holding tank within the small volume prover to improve overall accuracy of the proving measurements. When liquid is pumped into the prover evaporation of the liquid being pumped into the prover, and release of vapors from the prover and into the entire holding tank, is inhibited due to the saturated vapor environment established by a saturated vapor volume in the prover, which results in a more accurate prover measurement of liquid pumped into the prover.

Abstract: A first container is provided including a first base, a first wall, a second wall, a third wall, and a fourth wall. The first, second, third, and fourth walls, can each be placed in an erect state, substantially perpendicular to the first base or in a collapsed state substantially parallel to the first base. The first and second walls, which oppose each other, can also be placed in ramp states to allow a vehicle or cargo to be rolled over the first or second walls and onto the first base. Inverted J-shaped slots allow the first wall or the second wall to pivot about multiple pivot points with respect to the base.

Abstract: A method and composition are provided for treating intracellular pathogens that reside in phagosomes. The compositions include antibiotics which are conjugated with transferrin or other ligands to form conjugates that target membrane-bound pathogens. The conjugates are selectively taken up by infected phagosomes. Conjugates are provided which utilize transferrin as the targeting ligand for treating mycobacterium which reside in membrane-bound phagosomes.