Patents by Inventor Daniel L. Comins

Daniel L. Comins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis and regioselective substitution of 6-halo- and 6-alkoxy nicotine derivatives
    Patent number: 8389732
    Abstract: The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: March 5, 2013
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Florence F. Wagner, Pauline Ondachi
  • NICOTINE-BASED COMPOUNDS USEFUL FOR ASYMMETRIC SYNTHESIS
    Publication number: 20110251390
    Abstract: Chiral amino alcohol and amino phosphine compounds are provided herein, which compounds are useful for asymmetric synthesis.
    Type: Application
    Filed: October 2, 2009
    Publication date: October 13, 2011
    Inventors: Daniel L. Comins, Sonja S. Capracotta
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 7888512
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: February 15, 2011
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Regiospecific synthesis of nicotine derivatives
    Patent number: 7875724
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 25, 2011
    Assignee: North Carolina State University
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES
    Publication number: 20100331323
    Abstract: The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds.
    Type: Application
    Filed: September 10, 2010
    Publication date: December 30, 2010
    Inventors: Daniel L. Comins, Florence F. Wagner, Pauline Ondachi
  • Synthesis and regioselective substitution of 6-halo-and 6-alkoxy nicotine derivatives
    Patent number: 7820826
    Abstract: The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: October 26, 2010
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Florence F. Wagner, Pauline Ondachi
  • REGIOSPECIFIC SYNTHESIS OF NICOTINE DERIVATIVES
    Publication number: 20100113785
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Application
    Filed: January 15, 2010
    Publication date: May 6, 2010
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • Regiospecific synthesis of nicotine derivatives
    Patent number: 7671209
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: March 2, 2010
    Assignee: North Carolina State University
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • SYNTHESIS OF NICOTINE DERIVATIVES FROM NICOTINE
    Publication number: 20090234129
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Application
    Filed: May 27, 2009
    Publication date: September 17, 2009
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 7553968
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: June 30, 2009
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Regioselective halogenation of nicotine and substituted nicotines
    Patent number: 7501520
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: March 10, 2009
    Assignee: North Carlina State University
    Inventors: Daniel L. Comins, Florence Fevrier, Emilie Despagnet Smith
  • SYNTHESIS OF NICOTINE DERIVATIVES FROM NICOTINE
    Publication number: 20080154041
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Application
    Filed: March 7, 2008
    Publication date: June 26, 2008
    Applicant: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 7361768
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: April 22, 2008
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Regiospecific synthesis of nicotine derivatives
    Patent number: 7304160
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: December 4, 2007
    Assignee: North Carolina State University
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO-AND 6-ALKOXY NICOTINE DERIVATIVES
    Publication number: 20070232665
    Abstract: The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 4, 2007
    Inventors: Daniel L. Comins, Florence F. Wagner, Pauline Ondachi
  • Regioselective halogenation of nicotine and substituted nicotines
    Patent number: 7179917
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: February 20, 2007
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Florence Fevrier, Emilie Despagnet Smith
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 7132545
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: November 7, 2006
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Regiospecific synthesis of nicotine derivatives
    Patent number: 7112678
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: September 26, 2006
    Assignee: North Carolina State University
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • Regioselective halogenation of nicotine and substituted nicotines
    Patent number: 7067672
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: June 27, 2006
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Florence Fevrier, Emilie Despagnet Smith
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 6995265
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: February 7, 2006
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith