Patents by Inventor Daniel L. Feldheim
Daniel L. Feldheim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8178163Abstract: The present invention discloses gradients and methods of forming gradients. The gradients can form a component of a molecular machine, such as those disclosed herein. The molecular machines of the present invention can perform a range of tasks including nanoparticle heterostructure assembly, derivatization of a nanoparticle and synthesis of biomolecules, to name just a few applications.Type: GrantFiled: October 9, 2009Date of Patent: May 15, 2012Assignee: North Carolina State UniversityInventors: Christopher B. Gorman, Daniel L. Feldheim, Ryan R. Fuierer
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Patent number: 7829275Abstract: A method of detecting the presence of an analyte, such as a target nucleic acid sequence, protein sequence or small molecule, which can also be employed to detect the formation of duplex structures, is disclosed. The method can comprise nucleic acids, proteins and small molecules, employing photoelectrochemically active nanoparticles, branched polymers or other structures that carry photoelectrochemically active molecules capable of generating a photocurrent when excited by light in the presence of an electric field is disclosed. The method can be employed to detect hybridization on an array and can be employed in sequencing, mutational analysis (for example, single nucleotide polymorphisms and other variations in a population) and for monitoring gene expression by analysis of the level of expression of messenger RNA extracted from a cell. The method is applicable to the detection of antibody binding or other protein binding for analyte detection in an array format.Type: GrantFiled: September 6, 2002Date of Patent: November 9, 2010Assignee: North Carolina State UniversityInventors: Stefan Franzen, Daniel L. Feldheim
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Publication number: 20100255194Abstract: The present invention discloses gradients and methods of forming gradients. The gradients can form a component of a molecular machine, such as those disclosed herein. The molecular machines of the present invention can perform a range of tasks including nanoparticle heterostructure assembly, derivatization of a nanoparticle and synthesis of biomolecules, to name just a few applications.Type: ApplicationFiled: October 9, 2009Publication date: October 7, 2010Inventors: Christopher B. Gorman, Daniel L. Feldheim, Ryan R. Fuierer
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Patent number: 7601394Abstract: The present invention discloses gradients and methods of forming gradients. The gradients can form a component of a molecular machine, such as those disclosed herein. The molecular machines of the present invention can perform a range of tasks including nanoparticle heterostructure assembly, derivatization of a nanoparticle and synthesis of biomolecules, to name just a few applications.Type: GrantFiled: October 28, 2005Date of Patent: October 13, 2009Assignee: North Carolina State UniversityInventors: Christopher B. Gorman, Daniel L. Feldheim, Ryan R. Fuierer
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Publication number: 20080199529Abstract: A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.Type: ApplicationFiled: February 15, 2008Publication date: August 21, 2008Inventors: Stefan Franzen, Daniel L. Feldheim, Alexander G. Tkachenko, Marisha L. Godek, Joseph A. Ryan, Miles F. Anderson
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Patent number: 7332586Abstract: A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.Type: GrantFiled: July 10, 2002Date of Patent: February 19, 2008Assignee: North Carolina State UniversityInventors: Stefan Franzen, Daniel L. Feldheim, Alexander G. Tkachenko, Marisha L. Godek, Joseph A. Ryan, Stefan Franzen, legal representative, Miles F. Anderson
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Patent number: 6972155Abstract: The present invention discloses gradients and methods of forming gradients. The gradients can form a component of a molecular machine, such as those disclosed herein. The molecular machines of the present invention can perform a range of tasks including nanoparticle heterostructure assembly, derivatization of a nanoparticle and synthesis of biomolecules, to name just a few applications.Type: GrantFiled: January 16, 2003Date of Patent: December 6, 2005Assignee: North Carolina State UniversityInventors: Christopher B. Gorman, Daniel L. Feldheim, Ryan R. Fuierer
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Publication number: 20030170480Abstract: The present invention discloses gradients and methods of forming gradients. The gradients can form a component of a molecular machine, such as those disclosed herein. The molecular machines of the present invention can perform a range of tasks including nanoparticle heterostructure assembly, derivatization of a nanoparticle and synthesis of biomolecules, to name just a few applications.Type: ApplicationFiled: January 16, 2003Publication date: September 11, 2003Applicant: North Carolina State UniversityInventors: Christopher B. Gorman, Daniel L. Feldheim, Ryan R. Fuierer
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Publication number: 20030147966Abstract: A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.Type: ApplicationFiled: July 10, 2002Publication date: August 7, 2003Inventors: Stefan Franzen, Daniel L. Feldheim, Alexander G. Tkachenko, Marisha L. Godek, Joseph A. Ryan, Miles F. Anderson, Stefan Franzen
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Patent number: 6602932Abstract: Nanoparticle composites and nanocapsules for guest encapsulation and methods for synthesizing same. One synthesis method includes providing a nanoparticle template; and forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template to form a nanoparticle composite defined by the shell and the nanoparticle template. Another synthesis method includes providing a nanoparticle template; forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template; and dissolving the nanoparticle template to thereby form a hollow nanocapsule defined by the shell. Another synthesis method includes providing a nanoparticle template carrying a guest molecule; and forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template to thereby encapsulate the guest molecule.Type: GrantFiled: December 15, 2000Date of Patent: August 5, 2003Assignee: North Carolina State UniversityInventors: Daniel L. Feldheim, Stella M. Marinakos, David A. Shultz
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Publication number: 20030143581Abstract: A method of detecting the presence of an analyte, such as a target nucleic acid sequence, protein sequence or small molecule, which can also be employed to detect the formation of duplex structures, is disclosed. The method can comprise nucleic acids, proteins and small molecules, employing photoelectrochemically active nanoparticles, branched polymers or other structures that carry photoelectrochemically active molecules capable of generating a photocurrent when excited by light in the presence of an electric field is disclosed. The method can be employed to detect hybridization on an array and can be employed in sequencing, mutational analysis (for example, single nucleotide polymorphisms and other variations in a population) and for monitoring gene expression by analysis of the level of expression of messenger RNA extracted from a cell. The method is applicable to the detection of antibody binding or other protein binding for analyte detection in an array format.Type: ApplicationFiled: September 6, 2002Publication date: July 31, 2003Inventors: Stefan Franzen, Daniel L. Feldheim
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Publication number: 20020115747Abstract: Nanoparticle composites and nanocapsules for guest encapsulation and methods for synthesizing same. One synthesis method includes providing a nanoparticle template; and forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template to form a nanoparticle composite defined by the shell and the nanoparticle template. Another synthesis method includes providing a nanoparticle template; forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template; and dissolving the nanoparticle template to thereby form a hollow nanocapsule defined by the shell. Another synthesis method includes providing a nanoparticle template carrying a guest molecule; and forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template to thereby encapsulate the guest molecule.Type: ApplicationFiled: December 15, 2000Publication date: August 22, 2002Applicant: North Carolina State UniversityInventors: Daniel L. Feldheim, Stella M. Marinakos, David A. Shultz