Patents by Inventor Daniel L. Kacian
Daniel L. Kacian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180216172Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: December 15, 2017Publication date: August 2, 2018Inventors: Daniel L. Kacian, Kenneth A. Browne
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Patent number: 9856527Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: GrantFiled: May 23, 2016Date of Patent: January 2, 2018Assignee: GEN-PROBE INCORPORATEDInventors: Daniel L. Kacian, Kenneth A. Browne
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Publication number: 20160258009Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: May 23, 2016Publication date: September 8, 2016Inventors: Daniel L. KACIAN, Kenneth A. BROWNE
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Patent number: 9371556Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.Type: GrantFiled: March 4, 2005Date of Patent: June 21, 2016Assignee: GEN-PROBE INCORPORATEDInventors: Norman C. Nelson, Kenneth A. Browne, Lizhong Dai, James Russell, Mark E. Filipowsky, Margarita B. Kaminsky, Daniel L. Kacian
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Patent number: 9347098Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: GrantFiled: December 8, 2014Date of Patent: May 24, 2016Assignee: GEN-PROBE INCORPORATEDInventors: Daniel L. Kacian, Kenneth A. Browne
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Publication number: 20150093753Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: December 8, 2014Publication date: April 2, 2015Inventors: Daniel L. Kacian, Kenneth A. Browne
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Patent number: 8932817Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: GrantFiled: October 28, 2013Date of Patent: January 13, 2015Assignee: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Kenneth A. Browne
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Publication number: 20140231710Abstract: The disclosure relates to formulations for use in deactivating nucleic acids and methods of making and using the same.Type: ApplicationFiled: April 24, 2014Publication date: August 21, 2014Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Kenneth A. BROWNE, Lizhong DAI, James RUSSELL, Mark E. FILIPOWSKY, Margarita B. KAMINSKY, Daniel L. KACIAN
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Patent number: 8765652Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.Type: GrantFiled: June 25, 2012Date of Patent: July 1, 2014Assignee: Gen-Probe IncorporatedInventors: Norman C. Nelson, Kenneth A. Browne, Lizhong Dai, James Russell, Mark E. Filipowsky, Margarita B. Kaminsky, Daniel L. Kacian
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Patent number: 8685347Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.Type: GrantFiled: November 15, 2011Date of Patent: April 1, 2014Assignee: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter
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Publication number: 20140072974Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: October 28, 2013Publication date: March 13, 2014Applicant: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Kenneth A. Browne
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Publication number: 20140053662Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.Type: ApplicationFiled: November 15, 2011Publication date: February 27, 2014Applicant: GEN-PROBE INCORPORATEDInventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter
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Patent number: 8628924Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: GrantFiled: July 21, 2010Date of Patent: January 14, 2014Assignee: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Kenneth A. Browne
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Patent number: 8535621Abstract: A cap having a plurality of rib structures situated on an inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap.Type: GrantFiled: June 17, 2008Date of Patent: September 17, 2013Assignee: Gen-Probe IncorporatedInventors: Mordi I. Iheme, Daniel L. Kacian, Mark R. Kennedy
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Publication number: 20130160574Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.Type: ApplicationFiled: November 15, 2011Publication date: June 27, 2013Applicant: GEN-PROBE INCORPORATEDInventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter
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Publication number: 20120260951Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.Type: ApplicationFiled: June 25, 2012Publication date: October 18, 2012Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Kenneth A. BROWNE, Lizhong DAI, James RUSSELL, Mark E. FILIPOWSKY, Margarita B. KAMINSKY, Daniel L. KACIAN
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Patent number: 8221705Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: GrantFiled: December 17, 2008Date of Patent: July 17, 2012Assignee: Gen-Probe, IncorporatedInventors: Scott S. Breidenthal, Daniel L. Kacian, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 8211710Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.Type: GrantFiled: October 30, 2007Date of Patent: July 3, 2012Inventors: Kathleen A. Dickey, Bruce W. Anderson, Mordi I. Iheme, Nick M. Carter, Daniel L. Kacian
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Patent number: 8206662Abstract: A cap including a penetrable material adapted to be pierced by a fluid transfer device and an absorbent material positioned above the penetrable material. The absorbent material permits passage of the fluid transfer device and absorbs fluid material present on an outer surface of the fluid transfer device as it is being removed from the cap. The cap is useful for accessing the contents of an associated fluid-holding vessel multiple times.Type: GrantFiled: October 29, 2007Date of Patent: June 26, 2012Assignee: Gen-Probe IncorporatedInventors: Nick M. Carter, Daniel L. Kacian
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Patent number: RE45194Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.Type: GrantFiled: November 8, 2013Date of Patent: October 14, 2014Assignee: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter